[Term]
id: PR:000062613
name: epidermal growth factor receptor sequence variant T790M/L858R, signal peptide removed form (human)
def: "An epidermal growth factor receptor (human) that has a Met residue at the position equivalent to Thr-790 and an Arg residue at the position equivalent to Leu-858 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Thr-790, CHEBI:16044|Leu-858, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-1181386]
comment: Category=organism-modification.
synonym: "hEGFR/var:(T790M/L858R)/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "EGFR L858R;T790M" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-1181386]
synonym: "UniProtKB:P00533, 25-1210, Thr-790, CHEBI:16044|Leu-858, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P00533-1, 25-1210, Thr-790, CHEBI:16044|Leu-858, CHEBI:29952" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1181386 "PR:000086037 located_in GO:0005886"
is_a: PR:P00533 ! epidermal growth factor receptor (human)
relationship: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens