[Term]
id: PR:000037448
name: pTIRAP:PIP2:BTK:activated TLR4 complex (human)
def: "A TIRAP:PIP2:BTK:activated TLR4 complex in human that is composed of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, CD14, LPS. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex." [PMID:12888566, Reactome:R-HSA-2201325]
comment: Category=organism-complex. Kinase=("TIRAP:PIP2:BTK:activated TLR4 complex (human)"; PR:000037447).
synonym: "p-4Y-MAL:PI(4,5)P2:BTK:activated TLR4 (human)" EXACT [Reactome:R-HSA-2201325]
synonym: "p-4Y-TIRAP:PI(4,5)P2:BTK:activated TLR4 (human)" EXACT [Reactome:R-HSA-2201325]
synonym: "p4Y-MAL:PIP2:BTK:activated TLR4 (human)" EXACT [Reactome:R-HSA-2201325]
is_a: PR:000037472 ! TIRAP:PIP2:BTK:activated TLR4 complex
relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component PR:000037480 {cardinality="2"} ! CD14 molecule cleaved 2 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000027214 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human)
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000044351 {cardinality="2"} ! tyrosine-protein kinase BTK, initiator methionine removed form (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens