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Protein Ontology report - NF-kappa-B essential modulator (human)
PR:Q9Y6K9 - http://purl.obolibrary.org/obo/PR_Q9Y6K9
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q9Y6K9   
  PRO nameNF-kappa-B essential modulator (human) 
  Synonyms
PRO-Short-label: EXACT:hIKBKG
Gene-based: RELATED:FIP3 | IKBKG | NEMO
Other: EXACT:FIP-3 (human) | I-kappa-B kinase subunit gamma (human) | IkB kinase subunit gamma (human) | IkB kinase-associated protein 1 (human) | IKK-gamma (human) | IKKAP1 (human) | IKKG (human) | inhibitor of nuclear factor kappa-B kinase subunit gamma (human) | NF-kappa-B essential modifier (human)
  Definition"An NF-kappa-B essential modulator that is encoded in the genome of human." [PRO:DNx] 
  PRO Categoryorganism-gene 
  ParentPR:000001752 NF-kappa-B essential modulator
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:5961 IKBKG (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 9                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q9Y6K9
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:Q9Y6K9

NF-kappa-B essential modulator (human)

hIKBKG


"An NF-kappa-B essential modulator that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:000060620

NF-kappa-B essential modulator sequence variant C417R (human)

hIKBKG/var:C417R


"An NF-kappa-B essential modulator (human) that has an Arg residue at the position equivalent to Cys-417 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Cys-417, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-5262858]


organism-sequence



PR:000061455

NF-kappa-B essential modulator sequence variant R175P (human)

hIKBKG/var:R175P


"An NF-kappa-B essential modulator (human) that has a Pro residue at the position equivalent to Arg-175 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Arg-175, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-5262916]


organism-sequence



PR:000062347

NF-kappa-B essential modulator sequence variant R173G (human)

hIKBKG/var:R173G


"An NF-kappa-B essential modulator (human) that has a Gly residue at the position equivalent to Arg-173 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Arg-173, CHEBI:29947." [PRO:DNx, Reactome:R-HSA-5262966]


organism-sequence



PR:000062826

NF-kappa-B essential modulator sequence variant D406V (human)

hIKBKG/var:D406V


"An NF-kappa-B essential modulator (human) that has a Val residue at the position equivalent to Asp-406 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Asp-406, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-5262943]


organism-sequence



PR:000062944

NF-kappa-B essential modulator sequence variant L153R (human)

hIKBKG/var:L153R


"An NF-kappa-B essential modulator (human) that has an Arg residue at the position equivalent to Leu-153 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Leu-153, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-5262879]


organism-sequence



PR:000064418

NF-kappa-B essential modulator sequence variant E391* (human)

hIKBKG/var:E391*


"An NF-kappa-B essential modulator (human) that has has been truncated after the position equivalent to Glu-390 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, 1-390." [PRO:DNx, Reactome:R-HSA-5262924]


organism-sequence



PR:Q9Y6K9-1

NF-kappa-B essential modulator isoform 1 (human)

hIKBKG/iso:1


"An NF-kappa-B essential modulator isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000036612

NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human)

hIKBKG/iso:1/Phos:1


"An NF-kappa-B essential modulator isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6K9-1, Ser-31/Ser-43/Ser-376, MOD:00046." [PMID:12657630, PRO:CNA]


organism-modification



PR:000036613

NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human)

hIKBKG/iso:1/Phos:2


"An NF-kappa-B essential modulator isoform 1 phosphorylated 2 in human. UniProtKB:Q9Y6K9-1, Ser-68, MOD:00046." [PMID:17977820, PRO:CNA]


organism-modification



PR:000036614

NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human)

hIKBKG/iso:1/Phos:3


"An NF-kappa-B essential modulator isoform 1 phosphorylated 3 in human. UniProtKB:Q9Y6K9-1, Ser-85, MOD:00046." [PMID:16497931, PRO:CNA]


organism-sequence



PR:Q9Y6K9-2

NF-kappa-B essential modulator isoform h2 (human)

hIKBKG/iso:h2


"An NF-kappa-B essential modulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6K9-2." [PRO:DNx, UniProtKB:Q9Y6K9]


organism-sequence



PR:Q9Y6K9-3

NF-kappa-B essential modulator isoform h3 (human)

hIKBKG/iso:h3


"An NF-kappa-B essential modulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6K9-3." [PRO:DNx, UniProtKB:Q9Y6K9]


organism-modification



PR:000047980

NF-kappa-B essential modulator ubiquitinated 1 (human)

hIKBKG/Ubiq:1


"An NF-kappa-B essential modulator (human) that has been ubiquitinated on the residue at the position equivalent to Lys-285 of the amino acid sequence represented by UniProtKB:Q9Y6K9. UniProtKB:Q9Y6K9, Lys-285, MOD:01148." [PRO:DNx, Reactome:R-HSA-741397]


organism-modification



PR:000064705

NF-kappa-B essential modulator ubiquitinated 2 (human)

hIKBKG/Ubiq:2


"An NF-kappa-B essential modulator (human) that has been ubiquitinated on the residues at the positions equivalent to Lys-321, Lys-325, and Lys-326 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1 and that includes at least one additional ubiquitinated lysine. Example: UniProtKB:Q9Y6K9-1, Lys-321/Lys-325/Lys-326, MOD:01148|MOD:01148." [PRO:DNx, Reactome:R-HSA-202530]


organism-modification



PR:000064734

NF-kappa-B essential modulator sumoylated 1 (human)

hIKBKG/Sumo:1


"An NF-kappa-B essential modulator (human) that has been sumoylated on the residues at the positions equivalent to Lys-277 and Lys-309 of the amino acid sequence represented by UniProtKB:Q9Y6K9-1. Example: UniProtKB:Q9Y6K9-1, Lys-277/Lys-309, MOD:01149." [PRO:DNx, Reactome:R-HSA-4755449]


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hIKBKG forms found in complexes   

hIKBKG Component
Complexes
PR:Q9Y6K9 hIKBKG PR:000026457 IkappaB kinase complex (human)
PR:000035833 activated IkappaB kinase complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)