back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - interleukin-1 receptor-associated kinase 4 (human)
PR:Q9NWZ3 - http://purl.obolibrary.org/obo/PR_Q9NWZ3
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q9NWZ3   
  PRO nameinterleukin-1 receptor-associated kinase 4 (human) 
  Synonyms
PRO-Short-label: EXACT:hIRAK4
Gene-based: RELATED:IRAK4
Other: EXACT:IRAK-4 (human) | renal carcinoma antigen NY-REN-64 (human)
  Definition"An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-gene 
  ParentPR:000001780 interleukin-1 receptor-associated kinase 4
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:17967 IRAK4 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
UniProtKB:Q9NWZ3
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:Q9NWZ3

interleukin-1 receptor-associated kinase 4 (human)

hIRAK4


"An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:000060515

interleukin-1 receptor-associated kinase 4 sequence variant Q293* (human)

hIRAK4/var:Q293*


"An interleukin-1 receptor-associated kinase 4 (human) that has has been truncated after the position equivalent to Ala-292 of the amino acid sequence represented by UniProtKB:Q9NWZ3-1. Example: UniProtKB:Q9NWZ3-1, 1-292." [PRO:DNx, Reactome:R-HSA-5602426]


organism-sequence



PR:000061705

interleukin-1 receptor-associated kinase 4 sequence variant R12C (human)

hIRAK4/var:R12C


"An interleukin-1 receptor-associated kinase 4 (human) that has a Cys residue at the position equivalent to Arg-12 of the amino acid sequence represented by UniProtKB:Q9NWZ3-1. Example: UniProtKB:Q9NWZ3-1, Arg-12, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-5602511]


organism-sequence



PR:000062041

interleukin-1 receptor-associated kinase 4 sequence variant E402* (human)

hIRAK4/var:E402*


"An interleukin-1 receptor-associated kinase 4 (human) that has has been truncated after the position equivalent to Glu-401 of the amino acid sequence represented by UniProtKB:Q9NWZ3-1. Example: UniProtKB:Q9NWZ3-1, 1-401." [PRO:DNx, Reactome:R-HSA-5602517]


organism-sequence



PR:Q9NWZ3-1

interleukin-1 receptor-associated kinase 4 isoform 1 (human)

hIRAK4/iso:1


"An interleukin-1 receptor-associated kinase 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000027191

interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)

hIRAK4/iso:1/Phos:1


"An interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 in human. UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PMID:17141195, PRO:CNA]


Yes
organism-sequence



PR:Q9NWZ3-2

interleukin-1 receptor-associated kinase 4 isoform h2 (human)

hIRAK4/iso:h2


"An interleukin-1 receptor-associated kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NWZ3-2." [PRO:DNx, UniProtKB:Q9NWZ3]


organism-modification



PR:000027184

interleukin-1 receptor-associated kinase 4 unmodified form (human)

hIRAK4/UnMod


"An interleukin-1 receptor-associated kinase 4 unmodified form in human." [PRO:CNA]


Yes
organism-modification



PR:000048046

interleukin-1 receptor-associated kinase 4 phosphorylated 1 (human)

hIRAK4/Phos:1


"An interleukin-1 receptor-associated kinase 4 (human) that has been post-translationally modified to include phosphothreonine at positions 342 and 345, and phosphoserine at position 346 of the amino acid sequence represented by UniProtKB:Q9NWZ3. UniProtKB:Q9NWZ3, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PRO:DNx, Reactome:R-HSA-446649, Reactome:R-HSA-936957, Reactome:R-HSA-975149]


Back to top
hIRAK4 forms found in complexes   

hIRAK4 Component
Complexes
PR:000027184 hIRAK4/UnMod PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027191 hIRAK4/iso:1/Phos:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)