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Protein Ontology report - E3 ubiquitin-protein ligase SMURF1 (human)
PR:Q9HCE7 - http://purl.obolibrary.org/obo/PR_Q9HCE7
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q9HCE7   
  PRO nameE3 ubiquitin-protein ligase SMURF1 (human) 
  Synonyms
PRO-Short-label: EXACT:hSMURF1
Gene-based: RELATED:KIAA1625 | SMURF1
Other: EXACT:HECT-type E3 ubiquitin transferase SMURF1 (human) | SMAD ubiquitination regulatory factor 1 (human) | SMAD-specific E3 ubiquitin-protein ligase 1 (human)
  Definition"An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HCE7] 
  PRO Categoryorganism-gene 
  ParentPR:000000361 E3 ubiquitin-protein ligase SMURF1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:16807 SMURF1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q9HCE7
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q9HCE7
E3 ubiquitin-protein ligase SMURF1 (human)
hSMURF1
"An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HCE7]
Yes
organism-sequence


PR:Q9HCE7-1
E3 ubiquitin-protein ligase SMURF1 isoform Long (human)
hSMURF1/iso:Long
"An E3 ubiquitin-protein ligase SMURF1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCE7-1." [PRO:DNx, UniProtKB:Q9HCE7]

organism-sequence


PR:Q9HCE7-2
E3 ubiquitin-protein ligase SMURF1 isoform Short (human)
hSMURF1/iso:Short
"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000075773
E3 ubiquitin-protein ligase SMURF1 cysteinylated 1 (human)
hSMURF1/Cyst:1
"An E3 ubiquitin-protein ligase SMURF1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-725 of the amino acid sequence represented by UniProtKB:Q9HCE7-1. Example: UniProtKB:Q9HCE7-1, Cys-725, MOD:00765." [IEDB_epitope:1582149, PRO:DNx]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9HCE7 hSMURF1 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:10458166
PR:Q9HCE7-2 hSMURF1/iso:Short acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PMID:12857866
GO:0006511 ubiquitin-dependent protein catabolic process PMID:12857866
GO:0036211 protein modification process PMID:10458166
enablesGO:0004842 ubiquitin-protein transferase activity PMID:10458166
GO:0005515 protein binding PMID:11278251; PMID:16299379
located_inGO:0005622 intracellular anatomical structure PMID:10458166