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Protein Ontology report - aurora kinase B (human)
PR:Q96GD4 - http://purl.obolibrary.org/obo/PR_Q96GD4
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q96GD4   
  PRO nameaurora kinase B (human) 
  Synonyms
PRO-Short-label: EXACT:hAURKB
Gene-based: RELATED:AIK2 | AIM1 | AIRK2 | ARK2 | AURKB | STK1 | STK12 | STK5
Other: EXACT:AIM-1 (human) | ARK-2 (human) | aurora 1 (human) | aurora- and IPL1-like midbody-associated protein 1 (human) | aurora-related kinase 2 (human) | aurora/IPL1-related kinase 2 (human) | serine/threonine-protein kinase 12 (human) | serine/threonine-protein kinase 5 (human) | serine/threonine-protein kinase aurora-B (human)
  Definition"An aurora kinase B that is encoded in the genome of human." [PMID:12719470, PMID:15592459, PMID:15917996, PMID:17617734, PMID:20624902, PMID:21658950, PMID:22732840, PRO:KER] 
  PRO Categoryorganism-gene 
  ParentPR:000004517 aurora kinase B
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11390 AURKB (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q96GD4
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q96GD4
aurora kinase B (human)
hAURKB
"An aurora kinase B that is encoded in the genome of human." [PMID:12719470, PMID:15592459, PMID:15917996, PMID:17617734, PMID:20624902, PMID:21658950, PMID:22732840, PRO:KER]
Yes
organism-sequence


PR:Q96GD4-1
aurora kinase B isoform h1 (human)
hAURKB/iso:h1
"An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-1." [PRO:DNx, UniProtKB:Q96GD4]

organism-sequence


PR:Q96GD4-2
aurora kinase B isoform h2 (human)
hAURKB/iso:h2
"An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-2." [PRO:DNx, UniProtKB:Q96GD4]

organism-sequence


PR:Q96GD4-3
aurora kinase B isoform h3 (human)
hAURKB/iso:h3
"An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-3." [PRO:DNx, UniProtKB:Q96GD4]

organism-sequence


PR:Q96GD4-4
aurora kinase B isoform h4 (human)
hAURKB/iso:h4
"An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-4." [PRO:DNx, UniProtKB:Q96GD4]

organism-sequence


PR:Q96GD4-5
aurora kinase B isoform h5 (human)
hAURKB/iso:h5
"An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-5." [PRO:DNx, UniProtKB:Q96GD4]

organism-modification


PR:000035661
aurora kinase B unphosphorylated form (human)
hAURKB/PhosRes-
"An aurora kinase B unphosphorylated form in human." [PMID:22024163, PRO:KER]
Yes
organism-modification


PR:000035663
aurora kinase B phosphorylated 1 (human)
hAURKB/Phos:1
"An aurora kinase B phosphorylated 1 in human. This phosphorylated form is present during prometaphase, metaphase, and loss of tension on kinetochores (taxol). UniProtKB:Q96GD4, Ser-331, MOD:00046." [PMID:17276342, PMID:22024163, PMID:23321637, PRO:CNA, PRO:KER]
Yes
organism-modification


PR:000046026
aurora kinase B phosphorylated 2 (human)
hAURKB/Phos:2
"An aurora kinase B (human) that has been phosphorylated on the residue at the position equivalent to Thr-232 of the amino acid sequence represented by UniProtKB:Q96GD4-1. Example: UniProtKB:Q96GD4-1, Thr-232, MOD:00047." [iPTMnet:Q96GD4, PMID:14722118, PMID:18767990]

organism-modification


PR:000046440
aurora kinase B sumoylated 1 (human)
hAURKB/Sumo:1
"An aurora kinase B (human) that has been post-translationally modified to include sumoylated lysine at position 202 of the amino acid sequence represented by UniProtKB:Q96GD4. UniProtKB:Q96GD4, Lys-202, MOD:01149." [PRO:DNx, Reactome:R-HSA-4655414]

organism-modification


PR:000075980
aurora kinase B methylated 1 (human)
hAURKB/Me:1
"An aurora kinase B (human) that has been methylated on the residue at the position equivalent to Cys-170 of the amino acid sequence represented by UniProtKB:Q96GD4-1. Example: UniProtKB:Q96GD4-1, Cys-170, MOD:00660." [IEDB_epitope:1023665, PRO:DNx]

organism-modification


PR:000077527
aurora kinase B cysteinylated 1 (human)
hAURKB/Cyst:1
"An aurora kinase B (human) that has been cysteinylated on the residue at the position equivalent to Cys-170 of the amino acid sequence represented by UniProtKB:Q96GD4-1. Example: UniProtKB:Q96GD4-1, Cys-170, MOD:00765." [IEDB_epitope:1023664, PRO:DNx]

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007059 chromosome segregationPR:Q96GD4 hAURKB PMID:12719470
increased GO:0007059 chromosome segregationPR:000035663 hAURKB/Phos:1 PMID:22024163
GO:0008608 attachment of spindle microtubules to kinetochorePR:Q96GD4 hAURKB PMID:12719470; PMID:15592459
GO:0031577 spindle checkpoint signalingPR:Q96GD4 hAURKB PMID:12719470
increased GO:0031577 spindle checkpoint signalingPR:000035663 hAURKB/Phos:1 PMID:22024163
GO:0034501 protein localization to kinetochorePR:Q96GD4 hAURKB PMID:12719470; PMID:17617734; PMID:22732840
NOT GO:0051306 mitotic sister chromatid separationPR:Q96GD4 hAURKB PMID:12719470
GO:0051310 metaphase chromosome alignmentPR:Q96GD4 hAURKB PMID:12719470; PMID:22732840
increased GO:0051310 metaphase chromosome alignmentPR:000035663 hAURKB/Phos:1 PMID:22024163
GO:0071459 protein localization to chromosome, centromeric regionPR:Q96GD4 hAURKB PMID:12719470; PMID:21658950
GO:0140014 mitotic nuclear divisionPR:Q96GD4 hAURKB PMID:12719470

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004672 protein kinase activityPR:000035663 hAURKB/Phos:1 PMID:17276342; PMID:22024163
PR:Q96GD4 hAURKB PMID:12719470
GO:0005515 protein bindingPR:000035661 hAURKB/PhosRes- PMID:22024163
PR:000035663 hAURKB/Phos:1 PMID:22024163
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
PR:Q96GD4 hAURKB BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0000776 kinetochorePR:000035661 hAURKB/PhosRes- PMID:22024163
PR:000035663 hAURKB/Phos:1 PMID:22024163
PR:Q96GD4 hAURKB PMID:20624902
GO:0000779 condensed chromosome, centromeric regionPR:Q96GD4 hAURKB PMID:12719470; PMID:15917996
GO:0000939 inner kinetochorePR:Q96GD4 hAURKB PMID:15592459
GO:0030496 midbodyPR:Q96GD4 hAURKB PMID:15917996
GO:0051233 spindle midzonePR:Q96GD4 hAURKB PMID:15917996