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Protein Ontology report - TIR domain-containing adapter molecule 2 (human)
PR:Q86XR7 - http://purl.obolibrary.org/obo/PR_Q86XR7
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q86XR7   
  PRO nameTIR domain-containing adapter molecule 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hTICAM2
Gene-based: RELATED:TICAM2 | TIRAP3 | TIRP | TRAM
Other: EXACT:MyD88-4 (human) | putative NF-kappa-B-activating protein 502 (human) | TICAM-2 (human) | Toll-like receptor adaptor protein 3 (human) | Toll/interleukin-1 receptor domain-containing protein (human) | TRIF-related adapter molecule (human)
  Definition"A TIR domain-containing adapter molecule 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q86XR7] 
  PRO Categoryorganism-gene 
  ParentPR:000001750 TIR domain-containing adapter molecule 2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:21354 TICAM2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q86XR7
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q86XR7
TIR domain-containing adapter molecule 2 (human)
hTICAM2
"A TIR domain-containing adapter molecule 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q86XR7]

organism-sequence


PR:Q86XR7-1
TIR domain-containing adapter molecule 2 isoform 1 (human)
hTICAM2/iso:1
"A TIR domain-containing adapter molecule 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000027201
TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated 1 (human)
hTICAM2/iso:1/InitMet-/Myr:1
"A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at position 2 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068." [PRO:CNA]

organism-modification


PR:000040891
TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
hTICAM2/iso:1/InitMet-/MyrPhos:1
"A TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated form in human that has been myristoylated at Gly-2 and phosphorylated at Ser-16 of the amino acid sequence represented by UniProtKB:Q86XR7-1. UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068|Ser-16, MOD:00046." [PMID:16757566, PRO:DAN]

Yes
organism-sequence


PR:Q86XR7-2
TIR domain-containing adapter molecule 2 isoform h2 (human)
hTICAM2/iso:h2
"A TIR domain-containing adapter molecule 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q86XR7-2." [PRO:DNx, UniProtKB:Q86XR7]

organism-modification


PR:000063665
TIR domain-containing adapter molecule 2, initiator methionine removed myristoylated and phosphorylated 1 (human)
hTICAM2/InitMet-/MyrPhos:1
"A TIR domain-containing adapter molecule 2 (human) that has had the initiator methionine removed and that has been myristoylated on the residue at the position equivalent to Gly-2 and phosphorylated on the residue at the position equivalent to Ser-16 of the amino acid sequence represented by UniProtKB:Q86XR7-1. Example: UniProtKB:Q86XR7-1, 2-235, Gly-2, MOD:00068|Ser-16, MOD:00046." [PRO:DNx, Reactome:R-HSA-166160, Reactome:R-HSA-2201336, Reactome:R-HSA-6804964]

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hTICAM2 forms found in complexes   

hTICAM2 Component
 Complexes
PR:000040891 hTICAM2/iso:1/InitMet-/MyrPhos:1 PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028678 ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036024 rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036027 sarm:ticam1:ticam2:activated TLR4 complex (human)
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036049 K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036056 rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036058 rip1:rip3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036060 pro-caspase-8:fadd:rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)