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Protein Ontology report - mothers against decapentaplegic homolog 1 (human)
PR:Q15797 - http://purl.obolibrary.org/obo/PR_Q15797
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q15797   
  PRO namemothers against decapentaplegic homolog 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hSMAD1
Gene-based: RELATED:BSP1 | MADH1 | MADR1 | SMAD1
Other: EXACT:BSP-1 (human) | JV4-1 (human) | MAD homolog 1 (human) | Mad-related protein 1 (human) | mothers against DPP homolog 1 (human) | SMAD 1 (human) | SMAD family member 1 (human) | Smad1 (human) | transforming growth factor-beta-signaling protein 1 (human)
  Definition"A smad1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q15797] 
  PRO Categoryorganism-gene 
  ParentPR:000000363 smad1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6767 SMAD1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q15797
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q15797
mothers against decapentaplegic homolog 1 (human)
hSMAD1
"A smad1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q15797]

organism-sequence


PR:Q15797-1
mothers against decapentaplegic homolog 1 isoform 1 (human)
hSMAD1/iso:1
"A smad1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000026334
smad1 isoform 1 phosphorylated 1 (human)
hSMAD1/iso:1/Phos:1
"A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483]
Yes
organism-modification


PR:000036553
smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:Q15797-2
mothers against decapentaplegic homolog 1 isoform h2 (human)
hSMAD1/iso:h2
"A mothers against decapentaplegic homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15797-2." [PRO:DNx, UniProtKB:Q15797]

organism-modification


PR:000049280
mothers against decapentaplegic homolog 1 ubiquitinated form (human)
hSMAD1/UbiqLys+
"A mothers against decapentaplegic homolog 1 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q15797, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782768]

organism-modification


PR:000036553
smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)
hSMAD1/iso:1/PhosUbiq:1
"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000050147
smad1 phosphorylated 1 (human)
hSMAD1/Phos:1
"A smad1 phosphorylated 1 in human. UniProtKB:Q15797, Ser-463/Ser-465, MOD:00046." [PRO:DAN]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026334 hSMAD1/iso:1/Phos:1
UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:9759503
GO:0030509 BMP signaling pathway PMID:8653785
enablesGO:0046332 SMAD binding with PR:Q13485 deletion target in pancreatic carcinoma 4 (human) PMID:9136927
located_inGO:0005634 nucleus PMID:11509558; PMID:9759503
PR:000036553 hSMAD1/iso:1/PhosUbiq:1
UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148		 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:12857866
PR:Q15797-1 hSMAD1/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8637600
GO:0030509 BMP signaling pathway PMID:8653785
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
GO:0005102 signaling receptor binding PMID:9136927; PMID:9748228
GO:0005515 protein binding PMID:17356069
located_inGO:0005737 cytoplasm PMID:11509558