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Protein Ontology report - mothers against decapentaplegic homolog 2 (human)
PR:Q15796 -
http://purl.obolibrary.org/obo/PR_Q15796
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:Q15796
PRO name
mothers against decapentaplegic homolog 2 (human)
Synonyms
PRO-Short-label
:
EXACT:
hSMAD2
Gene-based
:
RELATED:
MADH2 | MADR2 | SMAD2
Other
:
EXACT:
hMAD-2 | JV18-1 (human) | MAD homolog 2 (human) | Mad-related protein 2 (human) | mothers against DPP homolog 2 (human) | SMAD 2 (human) | SMAD family member 2 (human) | Smad2 (human)
Definition
"A smad2 that is encoded in the genome of human." []
PRO Category
organism-gene
Parent
PR:000000364
smad2
PR:000029067
Homo sapiens protein
Gene Template
HGNC:6768
SMAD2 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
7
Modification
0
Organism-Modification
28
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:Q15796
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:Q15796
mothers against decapentaplegic homolog 2 (human)
hSMAD2
"A smad2 that is encoded in the genome of human." []
organism-sequence
PR:000000470
smad2 sequence variant R133C (human)
hSMAD2/var:R133C
"A mothers against decapentaplegic homolog 2 (human) that has a Cys residue at the position equivalent to Arg-133 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Arg-133, CHEBI:29950." [PMID:8752209, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000471
smad2 sequence variant L440R (human)
hSMAD2/var:L440R
"A mothers against decapentaplegic homolog 2 (human) that has an Arg residue at the position equivalent to Leu-440 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Leu-440, CHEBI:29952." [PMID:8752209, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000472
smad2 sequence variant P445H (human)
hSMAD2/var:P445H
"A mothers against decapentaplegic homolog 2 (human) that has a His residue at the position equivalent to Pro-445 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Pro-445, CHEBI:29979." [PMID:8752209, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000473
smad2 sequence variant D450E (human)
hSMAD2/var:D450E
"A mothers against decapentaplegic homolog 2 (human) that has a Glu residue at the position equivalent to Asp-450 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Asp-450, CHEBI:29972." [PMID:8752209, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000474
smad2 sequence variant 5 (human)
hSMAD2/var:5
"A mothers against decapentaplegic homolog 2 (human) that has a fifteen-residue deletion at the position equivalent to region 344-358 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, 2-343, 359-467." [PMID:8673135, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:Q15796-1
mothers against decapentaplegic homolog 2 isoform Long (human)
hSMAD2/iso:Long
"A smad2 isoform Long that is encoded in the genome of human." [PRO:CNA]
organism-modification
PR:000025934
smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
"A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]
Yes
Yes
organism-modification
PR:000025935
smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
"A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046." [PMID:12193595]
Yes
Yes
organism-modification
PR:000025936
smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
"A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046." [PMID:11027280]
Yes
Yes
organism-modification
PR:000025937
smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
"A smad2 isoform Long phosphorylated 4 in human. This form is phosphorylated at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region. UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046." [PMID:10197981]
Yes
organism-modification
PR:000036554
smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
"A smad2 isoform Long acetylated and phosphorylated 1 in human. UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756, PRO:CNA]
Yes
organism-modification
PR:000045371
smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1
"A mothers against decapentaplegic homolog 2 isoform Long (human) that lacks phosphorylation on the two last Ser of the C-terminal SSxS motif in human. UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291." [PRO:CNA]
Yes
Yes
organism-sequence
PR:Q15796-2
mothers against decapentaplegic homolog 2 isoform Short (human)
hSMAD2/iso:Short
"A smad2 isoform Short that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15796]
organism-modification
PR:000025938
smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
"A smad2 isoform Short phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]
Yes
Yes
organism-modification
PR:000036556
smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
"A smad2 isoform Short acetylated and phosphorylated 1 in human. UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756, PRO:CNA]
Yes
organism-modification
PR:000045494
smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1
"A mothers against decapentaplegic homolog 2 isoform Short (human) that lacks phosphorylation on the last two Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, PR:000026291." [PRO:CNA]
organism-modification
PR:000025960
smad2 isoform unphosphorylated 1 (human)
hSMAD2/iso:[Long/Short]/UnPhos:1
"A mothers against decapentaplegic homolog 2 (human) that lacks phosphorylation on the last two Ser of the C-terminal SSxS motif." [PMID:19135894, PRO:CNA, PRO:DAN]
organism-modification
PR:000045371
smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1
"A mothers against decapentaplegic homolog 2 isoform Long (human) that lacks phosphorylation on the two last Ser of the C-terminal SSxS motif in human. UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291." [PRO:CNA]
organism-modification
PR:000045494
smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1
"A mothers against decapentaplegic homolog 2 isoform Short (human) that lacks phosphorylation on the last two Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, PR:000026291." [PRO:CNA]
organism-modification
PR:000049281
mothers against decapentaplegic homolog 2, initiator methionine removed form (human)
hSMAD2/InitMet-
"A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed. UniProtKB:Q15796, 2-467." [PRO:DNx, Reactome:R-HSA-3006352, Reactome:R-HSA-3006353]
organism-modification
PR:000049282
mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human)
hSMAD2/InitMet-/Phos:1
"A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 465 and 467 of the amino acid sequence represented by UniProtKB:Q15796. UniProtKB:Q15796, 2-467, Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3009185, Reactome:R-HSA-3009186]
organism-modification
PR:000049283
mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human)
hSMAD2/InitMet-/Phos:5
"A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 220, and phosphoserine at positions 465 and 467 of the amino acid sequence represented by UniProtKB:Q15796. UniProtKB:Q15796, 2-467, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3009189]
organism-modification
PR:000049284
mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
hSMAD2/InitMet-/UbiqLys+
"A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and that includes at least one ubiquitinated lysine. UniProtKB:Q15796, 2-467, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782774]
organism-modification
PR:000064775
mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
hSMAD2/InitMet-/PhosUbiq:1
"A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed, that has been phosphorylated on the residues at the positions equivalent to Thr-220, Ser-465, and Ser-467 of the amino acid sequence represented by UniProtKB:Q15796-1, and that includes at least one ubiquitinated lysine. Example: UniProtKB:Q15796-1, 2-467, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-9773843]
organism-modification
PR:000060357
mothers against decapentaplegic homolog 2 sequence variant D300A, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300A/InitMet-/Phos:1
"A mothers against decapentaplegic homolog 2 (human) that has an Ala residue at the position equivalent to Asp-300 of the amino acid sequence represented by UniProtKB:Q15796-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-465 and Ser-467. Example: UniProtKB:Q15796-1, 2-467, Asp-300, CHEBI:46217|Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315064]
organism-modification
PR:000060522
mothers against decapentaplegic homolog 2 sequence variant S464L, initiator methionine removed form (human)
hSMAD2/var:S464L/InitMet-
"A mothers against decapentaplegic homolog 2 (human) that has a Leu residue at the position equivalent to Ser-464 of the amino acid sequence represented by UniProtKB:Q15796-1 and that has had the initiator methionine removed. Example: UniProtKB:Q15796-1, 2-467, Ser-464, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3304383]
organism-modification
PR:000060657
mothers against decapentaplegic homolog 2 sequence variant D300V, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300V/InitMet-/Phos:1
"A mothers against decapentaplegic homolog 2 (human) that has a Val residue at the position equivalent to Asp-300 of the amino acid sequence represented by UniProtKB:Q15796-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-465 and Ser-467. Example: UniProtKB:Q15796-1, 2-467, Asp-300, CHEBI:30015|Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315067]
organism-modification
PR:000060862
mothers against decapentaplegic homolog 2 sequence variant D300N, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:D300N/InitMet-/Phos:1
"A mothers against decapentaplegic homolog 2 (human) that has an Asn residue at the position equivalent to Asp-300 of the amino acid sequence represented by UniProtKB:Q15796-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-465 and Ser-467. Example: UniProtKB:Q15796-1, 2-467, Asp-300, CHEBI:50347|Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315066]
organism-modification
PR:000061944
mothers against decapentaplegic homolog 2 sequence variant A354T, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:A354T/InitMet-/Phos:1
"A mothers against decapentaplegic homolog 2 (human) that has a Thr residue at the position equivalent to Ala-354 of the amino acid sequence represented by UniProtKB:Q15796-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-465 and Ser-467. Example: UniProtKB:Q15796-1, 2-467, Ala-354, CHEBI:30013|Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315474]
organism-modification
PR:000062120
mothers against decapentaplegic homolog 2 sequence variant P305Q, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305Q/InitMet-/Phos:1
"A mothers against decapentaplegic homolog 2 (human) that has a Gln residue at the position equivalent to Pro-305 of the amino acid sequence represented by UniProtKB:Q15796-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-465 and Ser-467. Example: UniProtKB:Q15796-1, 2-467, Pro-305, CHEBI:30011|Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315070]
organism-modification
PR:000062419
mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 2 (human)
hSMAD2/InitMet-/Phos:2
"A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Ser-250 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, 2-467, Ser-250, MOD:00046." [PRO:DNx, Reactome:R-HSA-9731121]
organism-modification
PR:000063661
mothers against decapentaplegic homolog 2 sequence variant S464*, initiator methionine removed form (human)
hSMAD2/var:S464*/InitMet-
"A mothers against decapentaplegic homolog 2 (human) that has has been truncated after the position equivalent to Cys-463 of the amino acid sequence represented by UniProtKB:Q15796-1 and that has had the initiator methionine removed. Example: UniProtKB:Q15796-1, 2-463." [PRO:DNx, Reactome:R-HSA-3304362]
organism-modification
PR:000063912
mothers against decapentaplegic homolog 2 sequence variant S467P, initiator methionine removed form (human)
hSMAD2/var:S467P/InitMet-
"A mothers against decapentaplegic homolog 2 (human) that has a Pro residue at the position equivalent to Ser-467 of the amino acid sequence represented by UniProtKB:Q15796-1 and that has had the initiator methionine removed. Example: UniProtKB:Q15796-1, 2-467, Ser-467, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-3304375]
organism-modification
PR:000064349
mothers against decapentaplegic homolog 2 sequence variant P305L, initiator methionine removed phosphorylated 1 (human)
hSMAD2/var:P305L/InitMet-/Phos:1
"A mothers against decapentaplegic homolog 2 (human) that has a Leu residue at the position equivalent to Pro-305 of the amino acid sequence represented by UniProtKB:Q15796-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-465 and Ser-467. Example: UniProtKB:Q15796-1, 2-467, Pro-305, CHEBI:30006|Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315471]
organism-modification
PR:000049284
mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
hSMAD2/InitMet-/UbiqLys+
"A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and that includes at least one ubiquitinated lysine. UniProtKB:Q15796, 2-467, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782774]
organism-modification
PR:000064775
mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
hSMAD2/InitMet-/PhosUbiq:1
"A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed, that has been phosphorylated on the residues at the positions equivalent to Thr-220, Ser-465, and Ser-467 of the amino acid sequence represented by UniProtKB:Q15796-1, and that includes at least one ubiquitinated lysine. Example: UniProtKB:Q15796-1, 2-467, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-9773843]
organism-modification
PR:000050145
smad2 phosphorylated 1 (human)
hSMAD2/Phos:1
"A smad2 phosphorylated 1 in human. This form is phosphorylated in the last two Ser of the C-terminal SSxS motif. UniProtKB:Q15796, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]
organism-modification
PR:000065797
mothers against decapentaplegic homolog 2 methylated 1 (human)
hSMAD2/Me:1
"A mothers against decapentaplegic homolog 2 (human) that has been methylated on the residue at the position equivalent to Cys-81 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Cys-81, MOD:00660." [IEDB_epitope:1021722, IEDB_epitope:1059624, PRO:DNx]
organism-modification
PR:000077056
mothers against decapentaplegic homolog 2 cysteinylated 1 (human)
hSMAD2/Cyst:1
"A mothers against decapentaplegic homolog 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-161 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Cys-161, MOD:00765." [IEDB_epitope:925064, PRO:DNx]
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hSMAD2
forms found in complexes
hSMAD2
Component
Complexes
PR:000025934
hSMAD2/iso:Long/Phos:1
PR:000025933
smad2-smad4 protein complex 1 (human)
PR:000025951
smad2-smad4-ski protein complex 1 (human)
PR:000025935
hSMAD2/iso:Long/Phos:2
PR:000025946
smad2-smad4 protein complex 3 (human)
PR:000025936
hSMAD2/iso:Long/Phos:3
PR:000025947
smad2-smad4 protein complex 4 (human)
PR:000025938
hSMAD2/iso:Short/Phos:1
PR:000025940
smad2-smad4 protein complex 2 (human)
PR:000045371
hSMAD2/iso:Long/UnPhos:1
PR:000025952
smad2-smad4-ski protein complex 2 (human)
PR:000025965
TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000470
hSMAD2/var:R133C
Example: UniProtKB:Q15796-1, Arg-133, CHEBI:29950
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:8752209
associated_with_disease_progression
DO:5672
large intestine cancer
PMID:8752209
enables
NOT
GO:0003713
transcription coactivator activity
PMID:8752209
PR:000000471
hSMAD2/var:L440R
Example: UniProtKB:Q15796-1, Leu-440, CHEBI:29952
associated_with_disease_progression
DO:5672
large intestine cancer
PMID:8752209
PR:000000472
hSMAD2/var:P445H
Example: UniProtKB:Q15796-1, Pro-445, CHEBI:29979
associated_with_disease_progression
DO:5672
large intestine cancer
PMID:8752209
enables
NOT
GO:0003713
transcription coactivator activity
PMID:8752209
PR:000000473
hSMAD2/var:D450E
Example: UniProtKB:Q15796-1, Asp-450, CHEBI:29972
associated_with_disease_progression
DO:5672
large intestine cancer
PMID:8752209
enables
NOT
GO:0003713
transcription coactivator activity
PMID:8752209
PR:000000474
hSMAD2/var:5
Example: UniProtKB:Q15796-1, 2-343, 359-467
associated_with_disease_progression
DO:5672
large intestine cancer
PMID:8673135
enables
NOT
GO:0003713
transcription coactivator activity
PMID:8673135
PR:000025934
hSMAD2/iso:Long/Phos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046
acts_upstream_of_or_within
GO:0006355
regulation of DNA-templated transcription
PMID:15690394
;
PMID:9689110
GO:0007165
signal transduction
PMID:8752209
;
PMID:8980228
;
PMID:9346966
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:8752209
;
PMID:8980228
GO:0060395
SMAD protein signal transduction
PMID:9346966
enables
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
PMID:8980228
;
PMID:9346966
GO:0003713
transcription coactivator activity
PMID:9689110
GO:0046332
SMAD binding
PMID:9311995
located_in
GO:0005634
nucleus
PMID:9006934
;
PMID:9346966
PR:000025935
hSMAD2/iso:Long/Phos:2
Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
acts_upstream_of_or_within
GO:0006355
regulation of DNA-templated transcription
PMID:12193595
GO:0007165
signal transduction
PMID:12193595
GO:0060395
SMAD protein signal transduction
PMID:12193595
enables
GO:0000981
DNA-binding transcription factor activity, RNA polymerase II-specific
PMID:12193595
GO:0003712
transcription coregulator activity
PMID:12193595
GO:0046332
SMAD binding
PMID:12193595
located_in
GO:0005634
nucleus
PMID:12193595
;
PMID:17074053
PR:000025936
hSMAD2/iso:Long/Phos:3
UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:11027280
GO:0060395
SMAD protein signal transduction
PMID:11027280
enables
NOT
GO:0003713
transcription coactivator activity
PMID:11027280
GO:0046332
SMAD binding
PMID:11027280
located_in
GO:0005737
cytoplasm
PMID:11027280
PR:000025937
hSMAD2/iso:Long/Phos:4
UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046
enables
NOT
GO:0003713
transcription coactivator activity
PMID:10197981
located_in
GO:0005737
cytoplasm
PMID:10197981
PR:000025938
hSMAD2/iso:Short/Phos:1
UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:9873005
enables
GO:0003677
DNA binding
PMID:14701940
;
PMID:9873005
GO:0003700
DNA-binding transcription factor activity
PMID:9873005
GO:0003712
transcription coregulator activity
PMID:14701940
;
PMID:9873005
PR:000036554
hSMAD2/iso:Long/AcPhos:1
UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046
acts_upstream_of_or_within
GO:0006355
regulation of DNA-templated transcription
PMID:17074756
GO:0007165
signal transduction
PMID:17074756
located_in
GO:0005634
nucleus
PMID:17074756
PR:000036556
hSMAD2/iso:Short/AcPhos:1
UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:17074756
enables
GO:0003677
DNA binding
PMID:17074756
increased
GO:0003700
DNA-binding transcription factor activity
relative to
PR:000000656
SMAD2/iso:Short/Phos:1
PMID:17074756
PR:000045371
hSMAD2/iso:Long/UnPhos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:8752209
enables
GO:0005515
protein binding
PMID:8980228
located_in
GO:0005737
cytoplasm
PMID:15280432
;
PMID:17074053
GO:0005769
early endosome
PMID:12356868
