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Protein Ontology report - activin receptor type-2B (human)
PR:Q13705 - http://purl.obolibrary.org/obo/PR_Q13705
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q13705   
  PRO nameactivin receptor type-2B (human) 
  Synonyms
PRO-Short-label: EXACT:hACVR2B
Gene-based: RELATED:ACVR2B
Other: EXACT:activin receptor type IIB (human) | ACTR-IIB (human)
  Definition"An activin receptor type-2B that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13705] 
  PRO Categoryorganism-gene 
  ParentPR:000000071 activin receptor type-2B
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:174 ACVR2B (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q13705
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q13705
activin receptor type-2B (human)
hACVR2B
"An activin receptor type-2B that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13705]

organism-sequence


PR:000000214
activin receptor type-2B sequence variant R40H (human)
hACVR2B/var:R40H
"An activin receptor type-2B (human) that has a His residue at the position equivalent to Arg-40 of the amino acid sequence represented by UniProtKB:Q13705-1. This variation is within the extracellular domain. Example: UniProtKB:Q13705-1, Arg-40, CHEBI:29979." [PMID:9916847, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000215
activin receptor type-2B sequence variant V494I (human)
hACVR2B/var:V494I
"An activin receptor type-2B (human) that has an Ile residue at the position equivalent to Val-494 of the amino acid sequence represented by UniProtKB:Q13705-1. Example: UniProtKB:Q13705-1, Val-494, CHEBI:30009." [PMID:9916847, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:Q13705-1
activin receptor type-2B isoform ActR-IIB2 (human)
hACVR2B/iso:ActR-IIB2
"An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036443
activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)
hACVR2B/iso:ActR-IIB2/NGlycoPhos:1
"An activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 in human." [PMID:11279102, PMID:24337809, PMID:8161782, PMID:8622651, PMID:9872992, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:Q13705-2
activin receptor type-2B isoform ActR-IIBtrunc (human)
hACVR2B/iso:ActR-IIB1
"An activin receptor type-2B isoform ActR-IIBtrunc that is encoded in the genome of human." [PMID:9916847, PRO:DNx, UniProtKB:Q13705]
Yes
organism-modification


PR:000046259
activin receptor type-2B, signal peptide removed form (human)
hACVR2B/SigPep-
"An activin receptor type-2B (human) that has had the signal peptide removed. UniProtKB:Q13705, 19-512." [PRO:DNx, Reactome:R-HSA-201656]

organism-modification


PR:000076998
activin receptor type-2B phosphorylated 1 (human)
hACVR2B/Phos:1
"An activin receptor type-2B (human) that has been phosphorylated on the residue at the position equivalent to Tyr-387 of the amino acid sequence represented by UniProtKB:Q13705-1. Example: UniProtKB:Q13705-1, Tyr-387, MOD:00048." [IEDB_epitope:2146498, PRO:DNx]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000214 hACVR2B/var:R40H
Example: UniProtKB:Q13705-1, Arg-40, CHEBI:29979		 associated_with_disease_progressionDO:0050545 visceral heterotaxy PMID:9916847
PR:000000215 hACVR2B/var:V494I
Example: UniProtKB:Q13705-1, Val-494, CHEBI:30009		 associated_with_disease_progressionDO:0050545 visceral heterotaxy PMID:9916847
PR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:8622651
GO:0005515 protein binding PMID:11279102; PMID:9872992
GO:0016362 activin receptor activity, type II PMID:8622651
located_inGO:0005886 plasma membrane PMID:8161782
GO:0048179 activin receptor complex PMID:8622651
PR:Q13705-1 hACVR2B/iso:ActR-IIB2 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:8161782
PR:Q13705-2 hACVR2B/iso:ActR-IIB1 enablesNOT GO:0016362 activin receptor activity, type II PMID:9916847
located_inSO:0001587 stop_gained PMID:9916847