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Protein Ontology report - mothers against decapentaplegic homolog 4 (human)
PR:Q13485 - http://purl.obolibrary.org/obo/PR_Q13485
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q13485   
  PRO namemothers against decapentaplegic homolog 4 (human) 
  Synonyms
PRO-Short-label: EXACT:hSMAD4
Gene-based: RELATED:DPC4 | MADH4 | SMAD4
Other: EXACT:deletion target in pancreatic carcinoma 4 (human) | MAD homolog 4 (human) | mothers against DPP homolog 4 (human) | SMAD 4 (human) | SMAD family member 4 (human) | Smad4 (human)
  Definition"A smad4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13485
  PRO Categoryorganism-gene 
  ParentPR:000000128 smad4
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6770 SMAD4 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 89                                        
         Modification0                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q13485
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:Q13485

mothers against decapentaplegic homolog 4 (human)

hSMAD4


"A smad4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13485]


Yes
organism-sequence



PR:000000367

smad4 sequence variant E330G (human)

hSMAD4/var:E330G


"A mothers against decapentaplegic homolog 4 (human) that has a Gly residue at the position equivalent to Glu-330 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Glu-330, CHEBI:29947." [PMID:12417513, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000368

smad4 sequence variant G352R (human)

hSMAD4/var:G352R


"A mothers against decapentaplegic homolog 4 (human) that has an Arg residue at the position equivalent to Gly-352 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Gly-352, CHEBI:29952." [PMID:12417513, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000369

smad4 sequence variant R361C (human)

hSMAD4/var:R361C


"A mothers against decapentaplegic homolog 4 (human) that has a Cys residue at the position equivalent to Arg-361 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Arg-361, CHEBI:29950." [PMID:9811934, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000370

smad4 sequence variant G386D (human)

hSMAD4/var:G386D


"A mothers against decapentaplegic homolog 4 (human) that has an Asp residue at the position equivalent to Gly-386 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Gly-386, CHEBI:29958." [PMID:15031030, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000371

smad4 sequence variant D493H (human)

hSMAD4/var:D493H


"A mothers against decapentaplegic homolog 4 (human) that has a His residue at the position equivalent to Asp-493 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Asp-493, CHEBI:29979." [PMID:8553070, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000060297

mothers against decapentaplegic homolog 4 sequence variant E538* (human)

hSMAD4/var:E538*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Asp-537 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-537." [PRO:DNx, Reactome:R-HSA-9675626]


organism-sequence



PR:000060358

mothers against decapentaplegic homolog 4 sequence variant D351G (human)

hSMAD4/var:D351G


"A mothers against decapentaplegic homolog 4 (human) that has a Gly residue at the position equivalent to Asp-351 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Asp-351, CHEBI:29947." [PRO:DNx, Reactome:R-HSA-3310967]


organism-sequence



PR:000060432

mothers against decapentaplegic homolog 4 sequence variant G30* (human)

hSMAD4/var:G30*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Gly-29 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-29." [PRO:DNx, Reactome:R-HSA-9678450]


organism-sequence



PR:000060505

mothers against decapentaplegic homolog 4 sequence variant R445* (human)

hSMAD4/var:R445*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to His-444 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-444." [PRO:DNx, Reactome:R-HSA-9675065]


organism-sequence



PR:000060581

mothers against decapentaplegic homolog 4 sequence variant E390* (human)

hSMAD4/var:E390*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Leu-389 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-389." [PRO:DNx, Reactome:R-HSA-9675620]


organism-sequence



PR:000060584

mothers against decapentaplegic homolog 4 sequence variant G358* (human)

hSMAD4/var:G358*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ser-357 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-357." [PRO:DNx, Reactome:R-HSA-9678453]


organism-sequence



PR:000060627

mothers against decapentaplegic homolog 4 sequence variant Q410* (human)

hSMAD4/var:Q410*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Val-409 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-409." [PRO:DNx, Reactome:R-HSA-9675196]


organism-sequence



PR:000060690

mothers against decapentaplegic homolog 4 sequence variant D351H (human)

hSMAD4/var:D351H


"A mothers against decapentaplegic homolog 4 (human) that has a His residue at the position equivalent to Asp-351 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Asp-351, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-3310965]


organism-sequence



PR:000060699

mothers against decapentaplegic homolog 4 sequence variant E526* (human)

hSMAD4/var:E526*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ile-525 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-525." [PRO:DNx, Reactome:R-HSA-9675648]


organism-sequence



PR:000060742

mothers against decapentaplegic homolog 4 sequence variant Q83* (human)

hSMAD4/var:Q83*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Leu-82 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-82." [PRO:DNx, Reactome:R-HSA-9675199]


organism-sequence



PR:000060841

mothers against decapentaplegic homolog 4 sequence variant Y276* (human)

hSMAD4/var:Y276*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Pro-275 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-275." [PRO:DNx, Reactome:R-HSA-9678466]


organism-sequence



PR:000060874

mothers against decapentaplegic homolog 4 sequence variant G473* (human)

hSMAD4/var:G473*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Pro-472 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-472." [PRO:DNx, Reactome:R-HSA-9678440]


organism-sequence



PR:000060913

mothers against decapentaplegic homolog 4 sequence variant G477* (human)

hSMAD4/var:G477*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Gly-476 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-476." [PRO:DNx, Reactome:R-HSA-9678447]


organism-sequence



PR:000060944

mothers against decapentaplegic homolog 4 sequence variant E49* (human)

hSMAD4/var:E49*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Lys-48 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-48." [PRO:DNx, Reactome:R-HSA-9675651]


organism-sequence



PR:000060985

mothers against decapentaplegic homolog 4 sequence variant W398* (human)

hSMAD4/var:W398*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Val-397 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-397." [PRO:DNx, Reactome:R-HSA-9678498]


organism-sequence



PR:000060992

mothers against decapentaplegic homolog 4 sequence variant Q183* (human)

hSMAD4/var:Q183*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ile-182 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-182." [PRO:DNx, Reactome:R-HSA-9675176]


organism-sequence



PR:000061015

mothers against decapentaplegic homolog 4 sequence variant Y95* (human)

hSMAD4/var:Y95*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ile-94 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-94." [PRO:DNx, Reactome:R-HSA-9678478]


organism-sequence



PR:000061059

mothers against decapentaplegic homolog 4 sequence variant Q116* (human)

hSMAD4/var:Q116*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Cys-115 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-115." [PRO:DNx, Reactome:R-HSA-9675166]


organism-sequence



PR:000061241

mothers against decapentaplegic homolog 4 sequence variant W302* (human)

hSMAD4/var:W302*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Tyr-301 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-301." [PRO:DNx, Reactome:R-HSA-9678490]


organism-sequence



PR:000061304

mothers against decapentaplegic homolog 4 sequence variant E330* (human)

hSMAD4/var:E330*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Phe-329 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-329." [PRO:DNx, Reactome:R-HSA-9675622]


organism-sequence



PR:000061339

mothers against decapentaplegic homolog 4 sequence variant C443* (human)

hSMAD4/var:C443*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Gln-442 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-442." [PRO:DNx, Reactome:R-HSA-9678523]


organism-sequence



PR:000061457

mothers against decapentaplegic homolog 4 sequence variant Q249* (human)

hSMAD4/var:Q249*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Gln-248 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-248." [PRO:DNx, Reactome:R-HSA-9675172]


organism-sequence



PR:000061581

mothers against decapentaplegic homolog 4 sequence variant E108* (human)

hSMAD4/var:E108*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Asn-107 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-107." [PRO:DNx, Reactome:R-HSA-9675640]


organism-sequence



PR:000061625

mothers against decapentaplegic homolog 4 sequence variant Y412* (human)

hSMAD4/var:Y412*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ser-411 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-411." [PRO:DNx, Reactome:R-HSA-9678469]


organism-sequence



PR:000061684

mothers against decapentaplegic homolog 4 sequence variant W524* (human)

hSMAD4/var:W524*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Cys-523 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-523." [PRO:DNx, Reactome:R-HSA-9678491]


organism-sequence



PR:000061708

mothers against decapentaplegic homolog 4 sequence variant K428R (human)

hSMAD4/var:K428R


"A mothers against decapentaplegic homolog 4 (human) that has an Arg residue at the position equivalent to Lys-428 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Lys-428, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3311001]


organism-sequence



PR:000061756

mothers against decapentaplegic homolog 4 sequence variant E175* (human)

hSMAD4/var:E175*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Thr-174 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-174." [PRO:DNx, Reactome:R-HSA-9675637]


organism-sequence



PR:000061768

mothers against decapentaplegic homolog 4 sequence variant Q516* (human)

hSMAD4/var:Q516*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Arg-515 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-515." [PRO:DNx, Reactome:R-HSA-9675195]


organism-sequence



PR:000061774

mothers against decapentaplegic homolog 4 sequence variant L440* (human)

hSMAD4/var:L440*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Asp-439 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-439." [PRO:DNx, Reactome:R-HSA-9678510]


organism-sequence



PR:000061833

mothers against decapentaplegic homolog 4 sequence variant Q224* (human)

hSMAD4/var:Q224*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ser-223 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-223." [PRO:DNx, Reactome:R-HSA-9675168]


organism-sequence



PR:000061868

mothers against decapentaplegic homolog 4 sequence variant Q256* (human)

hSMAD4/var:Q256*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Gly-255 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-255." [PRO:DNx, Reactome:R-HSA-9675173]


organism-sequence



PR:000061967

mothers against decapentaplegic homolog 4 sequence variant A406T (human)

hSMAD4/var:A406T


"A mothers against decapentaplegic homolog 4 (human) that has a Thr residue at the position equivalent to Ala-406 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Ala-406, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-3311003]


organism-sequence



PR:000061978

mothers against decapentaplegic homolog 4 sequence variant W268* (human)

hSMAD4/var:W268*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Thr-267 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-267." [PRO:DNx, Reactome:R-HSA-9678494]


organism-sequence



PR:000062067

mothers against decapentaplegic homolog 4 sequence variant P356R (human)

hSMAD4/var:P356R


"A mothers against decapentaplegic homolog 4 (human) that has an Arg residue at the position equivalent to Pro-356 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Pro-356, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3310988]


organism-sequence



PR:000062090

mothers against decapentaplegic homolog 4 sequence variant Q248* (human)

hSMAD4/var:Q248*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Gly-247 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-247." [PRO:DNx, Reactome:R-HSA-9675178]


organism-sequence



PR:000062129

mothers against decapentaplegic homolog 4 sequence variant Y513* (human)

hSMAD4/var:Y513*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Asp-512 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-512." [PRO:DNx, Reactome:R-HSA-9678471]


organism-sequence



PR:000062175

mothers against decapentaplegic homolog 4 sequence variant G510* (human)

hSMAD4/var:G510*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Trp-509 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-509." [PRO:DNx, Reactome:R-HSA-9678452]


organism-sequence



PR:000062259

mothers against decapentaplegic homolog 4 sequence variant G352* (human)

hSMAD4/var:G352*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Asp-351 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-351." [PRO:DNx, Reactome:R-HSA-9678445]


organism-sequence



PR:000062302

mothers against decapentaplegic homolog 4 sequence variant R361G (human)

hSMAD4/var:R361G


"A mothers against decapentaplegic homolog 4 (human) that has a Gly residue at the position equivalent to Arg-361 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Arg-361, CHEBI:29947." [PRO:DNx, Reactome:R-HSA-3310993]


organism-sequence



PR:000062369

mothers against decapentaplegic homolog 4 sequence variant E307* (human)

hSMAD4/var:E307*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Asn-306 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-306." [PRO:DNx, Reactome:R-HSA-9675639]


organism-sequence



PR:000062486

mothers against decapentaplegic homolog 4 sequence variant D351Y (human)

hSMAD4/var:D351Y


"A mothers against decapentaplegic homolog 4 (human) that has a Tyr residue at the position equivalent to Asp-351 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Asp-351, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3310970]


organism-sequence



PR:000062687

mothers against decapentaplegic homolog 4 sequence variant W509* (human)

hSMAD4/var:W509*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Gly-508 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-508." [PRO:DNx, Reactome:R-HSA-9678497]


organism-sequence



PR:000062700

mothers against decapentaplegic homolog 4 sequence variant K428T (human)

hSMAD4/var:K428T


"A mothers against decapentaplegic homolog 4 (human) that has a Thr residue at the position equivalent to Lys-428 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Lys-428, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-3311004]


organism-sequence



PR:000062729

mothers against decapentaplegic homolog 4 sequence variant Q366* (human)

hSMAD4/var:Q366*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Gly-365 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-365." [PRO:DNx, Reactome:R-HSA-9675200]


organism-sequence



PR:000062770

mothers against decapentaplegic homolog 4 sequence variant R361S (human)

hSMAD4/var:R361S


"A mothers against decapentaplegic homolog 4 (human) that has a Ser residue at the position equivalent to Arg-361 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Arg-361, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3310994]


organism-sequence



PR:000062793

mothers against decapentaplegic homolog 4 sequence variant Y195* (human)

hSMAD4/var:Y195*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Thr-194 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-194." [PRO:DNx, Reactome:R-HSA-9678462]


organism-sequence



PR:000062878

mothers against decapentaplegic homolog 4 sequence variant Y328* (human)

hSMAD4/var:Y328*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ala-327 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-327." [PRO:DNx, Reactome:R-HSA-9678470]


organism-sequence



PR:000062888

mothers against decapentaplegic homolog 4 sequence variant Q289* (human)

hSMAD4/var:Q289*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Leu-288 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-288." [PRO:DNx, Reactome:R-HSA-9675177]


organism-sequence



PR:000062894

mothers against decapentaplegic homolog 4 sequence variant S154* (human)

hSMAD4/var:S154*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Pro-153 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-153." [PRO:DNx, Reactome:R-HSA-9675621]


organism-sequence



PR:000062923

mothers against decapentaplegic homolog 4 sequence variant W101* (human)

hSMAD4/var:W101*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Arg-100 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-100." [PRO:DNx, Reactome:R-HSA-9678492]


organism-sequence



PR:000062931

mothers against decapentaplegic homolog 4 sequence variant Q534* (human)

hSMAD4/var:Q534*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Leu-533 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-533." [PRO:DNx, Reactome:R-HSA-9675197]


organism-sequence



PR:000062943

mothers against decapentaplegic homolog 4 sequence variant L146* (human)

hSMAD4/var:L146*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Gly-145 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-145." [PRO:DNx, Reactome:R-HSA-9678509]


organism-sequence



PR:000062969

mothers against decapentaplegic homolog 4 sequence variant Q455* (human)

hSMAD4/var:Q455*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ala-454 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-454." [PRO:DNx, Reactome:R-HSA-9675193]


organism-sequence



PR:000063050

mothers against decapentaplegic homolog 4 sequence variant K122* (human)

hSMAD4/var:K122*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Leu-121 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-121." [PRO:DNx, Reactome:R-HSA-9678515]


organism-sequence



PR:000063052

mothers against decapentaplegic homolog 4 sequence variant R515T (human)

hSMAD4/var:R515T


"A mothers against decapentaplegic homolog 4 (human) that has a Thr residue at the position equivalent to Arg-515 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Arg-515, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-3311008]


organism-sequence



PR:000063094

mothers against decapentaplegic homolog 4 sequence variant P356L (human)

hSMAD4/var:P356L


"A mothers against decapentaplegic homolog 4 (human) that has a Leu residue at the position equivalent to Pro-356 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Pro-356, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3310987]


organism-sequence



PR:000063098

mothers against decapentaplegic homolog 4 sequence variant E417* (human)

hSMAD4/var:E417*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Arg-416 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-416." [PRO:DNx, Reactome:R-HSA-9675623]


organism-sequence



PR:000063207

mothers against decapentaplegic homolog 4 sequence variant Q311* (human)

hSMAD4/var:Q311*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Phe-310 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-310." [PRO:DNx, Reactome:R-HSA-9675169]


organism-sequence



PR:000063208

mothers against decapentaplegic homolog 4 sequence variant Y260* (human)

hSMAD4/var:Y260*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Thr-259 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-259." [PRO:DNx, Reactome:R-HSA-9678477]


organism-sequence



PR:000063251

mothers against decapentaplegic homolog 4 sequence variant Q239* (human)

hSMAD4/var:Q239*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Leu-238 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-238." [PRO:DNx, Reactome:R-HSA-9675174]


organism-sequence



PR:000063265

mothers against decapentaplegic homolog 4 sequence variant S242* (human)

hSMAD4/var:S242*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ala-241 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-241." [PRO:DNx, Reactome:R-HSA-9675167]


organism-sequence



PR:000063355

mothers against decapentaplegic homolog 4 sequence variant S138* (human)

hSMAD4/var:S138*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Val-137 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-137." [PRO:DNx, Reactome:R-HSA-9675649]


organism-sequence



PR:000063397

mothers against decapentaplegic homolog 4 sequence variant Q442* (human)

hSMAD4/var:Q442*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Arg-441 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-441." [PRO:DNx, Reactome:R-HSA-9675194]


organism-sequence



PR:000063419

mothers against decapentaplegic homolog 4 sequence variant R515* (human)

hSMAD4/var:R515*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Pro-514 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-514." [PRO:DNx, Reactome:R-HSA-3311012]


organism-sequence



PR:000063609

mothers against decapentaplegic homolog 4 sequence variant G168* (human)

hSMAD4/var:G168*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Glu-167 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-167." [PRO:DNx, Reactome:R-HSA-9678451]


organism-sequence



PR:000063714

mothers against decapentaplegic homolog 4 sequence variant E520* (human)

hSMAD4/var:E520*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Lys-519 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-519." [PRO:DNx, Reactome:R-HSA-9675636]


organism-sequence



PR:000063741

mothers against decapentaplegic homolog 4 sequence variant E205* (human)

hSMAD4/var:E205*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ser-204 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-204." [PRO:DNx, Reactome:R-HSA-9675650]


organism-sequence



PR:000063751

mothers against decapentaplegic homolog 4 sequence variant E53* (human)

hSMAD4/var:E53*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Asp-52 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-52." [PRO:DNx, Reactome:R-HSA-9675633]


organism-sequence



PR:000063757

mothers against decapentaplegic homolog 4 sequence variant R135* (human)

hSMAD4/var:R135*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Glu-134 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-134." [PRO:DNx, Reactome:R-HSA-9675090]


organism-sequence



PR:000063792

mothers against decapentaplegic homolog 4 sequence variant Q334* (human)

hSMAD4/var:Q334*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Val-333 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-333." [PRO:DNx, Reactome:R-HSA-9675191]


organism-sequence



PR:000063853

mothers against decapentaplegic homolog 4 sequence variant Y322* (human)

hSMAD4/var:Y322*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Glu-321 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-321." [PRO:DNx, Reactome:R-HSA-9678479]


organism-sequence



PR:000063915

mothers against decapentaplegic homolog 4 sequence variant Q245* (human)

hSMAD4/var:Q245*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Pro-244 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-244." [PRO:DNx, Reactome:R-HSA-9675175]


organism-sequence



PR:000063918

mothers against decapentaplegic homolog 4 sequence variant S144* (human)

hSMAD4/var:S144*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Leu-143 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-143." [PRO:DNx, Reactome:R-HSA-9675625]


organism-sequence



PR:000064002

mothers against decapentaplegic homolog 4 sequence variant Q250* (human)

hSMAD4/var:Q250*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Gln-249 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-249." [PRO:DNx, Reactome:R-HSA-9675170]


organism-sequence



PR:000064188

mothers against decapentaplegic homolog 4 sequence variant S178* (human)

hSMAD4/var:S178*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to His-177 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-177." [PRO:DNx, Reactome:R-HSA-9675630]


organism-sequence



PR:000064193

mothers against decapentaplegic homolog 4 sequence variant E33* (human)

hSMAD4/var:E33*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ser-32 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-32." [PRO:DNx, Reactome:R-HSA-9675654]


organism-sequence



PR:000064298

mothers against decapentaplegic homolog 4 sequence variant S171* (human)

hSMAD4/var:S171*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Pro-170 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-170." [PRO:DNx, Reactome:R-HSA-9675634]


organism-sequence



PR:000064338

mothers against decapentaplegic homolog 4 sequence variant Y430* (human)

hSMAD4/var:Y430*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ile-429 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-429." [PRO:DNx, Reactome:R-HSA-9678476]


organism-sequence



PR:000064356

mothers against decapentaplegic homolog 4 sequence variant S343* (human)

hSMAD4/var:S343*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Pro-342 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-342." [PRO:DNx, Reactome:R-HSA-9675641]


organism-sequence



PR:000064413

mothers against decapentaplegic homolog 4 sequence variant Q448* (human)

hSMAD4/var:Q448*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Met-447 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-447." [PRO:DNx, Reactome:R-HSA-9675192]


organism-sequence



PR:000064414

mothers against decapentaplegic homolog 4 sequence variant L172* (human)

hSMAD4/var:L172*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Ser-171 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-171." [PRO:DNx, Reactome:R-HSA-9678514]


organism-sequence



PR:000064437

mothers against decapentaplegic homolog 4 sequence variant E321* (human)

hSMAD4/var:E321*


"A mothers against decapentaplegic homolog 4 (human) that has has been truncated after the position equivalent to Pro-320 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, 1-320." [PRO:DNx, Reactome:R-HSA-9675658]


organism-sequence



PR:000064488

mothers against decapentaplegic homolog 4 sequence variant R361H (human)

hSMAD4/var:R361H


"A mothers against decapentaplegic homolog 4 (human) that has a His residue at the position equivalent to Arg-361 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Arg-361, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-3310984]


organism-sequence



PR:Q13485-1

mothers against decapentaplegic homolog 4 isoform 1 (human)

hSMAD4/iso:1


"A smad4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

Yes
organism-modification



PR:000025956

mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human)

hSMAD4/iso:1/MonoUbiq:1


"A smad4 isoform 1 monoubiquitinated 1 in human. UniProtKB:Q13485-1, Lys-507, MOD:01148." [PMID:18783722]


organism-modification



PR:000025958

mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human)

hSMAD4/iso:1/MonoUbiq:2


"A smad4 isoform 1 monoubiquitinated 2 in human. UniProtKB:Q13485-1, Lys-519, MOD:01148." [PMID:19135894]

Yes

organism-modification



PR:000036483

mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human)

hSMAD4/iso:1/Phos:1


"A smad4 isoform 1 phosphorylated 1 in human. UniProtKB:Q13485-1, Thr-277, MOD:00047." [PMID:12801888, PRO:CNA]

Yes

organism-modification



PR:000045915

mothers against decapentaplegic homolog 4 phosphorylated 1 (human)

hSMAD4/Phos:1


"A mothers against decapentaplegic homolog 4 (human) that has been phosphorylated at Thr-77. UniProtKB:Q13485, Thr-77, MOD:00047." [iPTMnet:Q13485, PMID:20974850]


organism-modification



PR:000049288

mothers against decapentaplegic homolog 4 ADP-ribosylated form (human)

hSMAD4/ADPribRes+


"A mothers against decapentaplegic homolog 4 (human) that includes at least one ADP-ribosylated residue. UniProtKB:Q13485, MOD:00752." [PRO:DNx, Reactome:R-HSA-2187323]


organism-modification



PR:000064798

mothers against decapentaplegic homolog 4 ubiquitinated form (human)

hSMAD4/UbiqLys+


"A mothers against decapentaplegic homolog 4 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q13485, MOD:01148." [PRO:DNx, Reactome:R-HSA-9773859, Reactome:R-HSA-9773863]


organism-modification



PR:000067581

mothers against decapentaplegic homolog 4 methylated 1 (human)

hSMAD4/Me:1


"A mothers against decapentaplegic homolog 4 (human) that has been methylated on the residue at the position equivalent to Cys-127 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Cys-127, MOD:00660." [IEDB_epitope:1004378, PRO:DNx]


organism-modification



PR:000074844

mothers against decapentaplegic homolog 4 methylated 2 (human)

hSMAD4/Me:2


"A mothers against decapentaplegic homolog 4 (human) that has been methylated on the residue at the position equivalent to Cys-123 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Cys-123, MOD:00660." [IEDB_epitope:1060570, PRO:DNx]


organism-modification



PR:000075597

mothers against decapentaplegic homolog 4 deaminated 1 (human)

hSMAD4/Deam:1


"A mothers against decapentaplegic homolog 4 (human) that has been deaminated on the residue at the position equivalent to Gln-410 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Gln-410, MOD:00685." [IEDB_epitope:1563936, PRO:DNx]


organism-modification



PR:000083975

mothers against decapentaplegic homolog 4 methylated 3 (human)

hSMAD4/Me:3


"A mothers against decapentaplegic homolog 4 (human) that has been methylated on the residue at the position equivalent to Cys-401 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Cys-401, MOD:00660." [IEDB_epitope:1014599, PRO:DNx]


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hSMAD4 forms found in complexes   

hSMAD4 Component
Complexes
PR:Q13485 hSMAD4 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:Q13485ZDASHZ1 hSMAD4/iso:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025952 smad2-smad4-ski protein complex 2 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000367 hSMAD4/var:E330G
UniProtKB:Q13485, Glu-330, CHEBI:29947
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000368 hSMAD4/var:G352R
UniProtKB:Q13485, Gly-352, CHEBI:29952
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
DO:4905 pancreatic carcinoma PMID:12417513
PR:000000369 hSMAD4/var:R361C
UniProtKB:Q13485, Arg-361, CHEBI:29950
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:9811934
PR:000000370 hSMAD4/var:G386D
UniProtKB:Q13485, Gly-386, CHEBI:29958
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:15031030
PR:000000371 hSMAD4/var:D493H
UniProtKB:Q13485, Asp-493, CHEBI:29979
associated_with_disease_progressionDO:4905 pancreatic carcinoma PMID:8553070
PR:000025958 hSMAD4/iso:1/MonoUbiq:2
UniProtKB:Q13485-1, Lys-519, MOD:01148
acts_upstream_of_or_withinGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:19135894
enablesNOT GO:0046332 SMAD binding PMID:19135894
PR:000036483 hSMAD4/iso:1/Phos:1
UniProtKB:Q13485-1, Thr-277, MOD:00047
acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12801888
enablesincreased GO:0003700 DNA-binding transcription factor activity relative to PR:000002539 SMAD4/iso:1/UnMod PMID:12801888
located_inGO:0005634 nucleus PMID:12801888
PR:Q13485-1 hSMAD4/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805; PMID:8774881
GO:0030509 BMP signaling pathway PMID:14633973
GO:0060395 SMAD protein signal transduction PMID:10980615; PMID:15350224; PMID:9346966
enablesGO:0003700 DNA-binding transcription factor activity PMID:10823886
GO:0003712 transcription coregulator activity PMID:10980615
located_inGO:0005634 nucleus PMID:10980615; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
GO:0005737 cytoplasm PMID:15280432