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Protein Ontology report - E3 ubiquitin-protein ligase Mdm2 (human)
PR:Q00987 - http://purl.obolibrary.org/obo/PR_Q00987
 
  Protein Forms      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:Q00987   
  PRO nameE3 ubiquitin-protein ligase Mdm2 (human) 
  Synonyms
PRO-Short-label: EXACT:hMDM2
Gene-based: RELATED:MDM2
Other: EXACT:double minute 2 protein (human) | Hdm2 (human) | oncoprotein Mdm2 (human) | p53-binding protein Mdm2 (human) | RING-type E3 ubiquitin transferase Mdm2 (human)
  Definition"An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q00987] 
  PRO Categoryorganism-gene 
  ParentPR:000010267 E3 ubiquitin-protein ligase Mdm2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6973 MDM2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q00987
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q00987
E3 ubiquitin-protein ligase Mdm2 (human)
hMDM2
"An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q00987]

organism-sequence


PR:Q00987-1
E3 ubiquitin-protein ligase Mdm2 isoform Mdm2 (human)
hMDM2/iso:Mdm2
"An E3 ubiquitin-protein ligase Mdm2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:Q00987-10
E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-G (human)
hMDM2/iso:hMdm2-G
"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-10." [PRO:DNx, UniProtKB:Q00987]

organism-sequence


PR:Q00987-11
E3 ubiquitin-protein ligase Mdm2 isoform h11 (human)
hMDM2/iso:h11
"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-11." [PRO:DNx, UniProtKB:Q00987]

organism-sequence


PR:Q00987-2
E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-A (human)
hMDM2/iso:hMdm2-A
"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-2." [PRO:DNx, UniProtKB:Q00987]

organism-sequence


PR:Q00987-3
E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-A1 (human)
hMDM2/iso:hMdm2-A1
"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-3." [PRO:DNx, UniProtKB:Q00987]

organism-sequence


PR:Q00987-4
E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-B (human)
hMDM2/iso:hMdm2-B
"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-4." [PRO:DNx, UniProtKB:Q00987]

organism-sequence


PR:Q00987-5
E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-C (human)
hMDM2/iso:hMdm2-C
"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-5." [PRO:DNx, UniProtKB:Q00987]

organism-sequence


PR:Q00987-6
E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-D (human)
hMDM2/iso:hMdm2-D
"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-6." [PRO:DNx, UniProtKB:Q00987]

organism-sequence


PR:Q00987-7
E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-E (human)
hMDM2/iso:hMdm2-E
"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-7." [PRO:DNx, UniProtKB:Q00987]

organism-sequence


PR:Q00987-8
E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-alpha (human)
hMDM2/iso:hMdm2-alpha
"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-8." [PRO:DNx, UniProtKB:Q00987]

organism-sequence


PR:Q00987-9
E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-F (human)
hMDM2/iso:hMdm2-F
"An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-9." [PRO:DNx, UniProtKB:Q00987]

organism-modification


PR:000045866
E3 ubiquitin-protein ligase Mdm2 phosphorylated 1 (human)
hMDM2/Phos:1
"An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-394 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Tyr-394, MOD:00048." [iPTMnet:Q00987, PMID:12110584]

organism-modification


PR:000048357
E3 ubiquitin-protein ligase Mdm2 phosphorylated 2 (human)
hMDM2/Phos:2
"An E3 ubiquitin-protein ligase Mdm2 (human) that has been post-translationally modified to include phosphoserine at positions 166 and 188 of the amino acid sequence represented by UniProtKB:Q00987. UniProtKB:Q00987, Ser-166/Ser-188, MOD:00046." [PRO:DNx, Reactome:R-HSA-198638, Reactome:R-HSA-6793669]

organism-modification


PR:000048358
E3 ubiquitin-protein ligase Mdm2 phosphorylated 3 (human)
hMDM2/Phos:3
"An E3 ubiquitin-protein ligase Mdm2 (human) that has been post-translationally modified to include phosphoserine at positions 166 and 188, and phosphothreonine at position 218 of the amino acid sequence represented by UniProtKB:Q00987. UniProtKB:Q00987, Ser-166/Ser-188, MOD:00046|Thr-218, MOD:00047." [PRO:DNx, Reactome:R-HSA-6792862]

organism-modification


PR:000048359
E3 ubiquitin-protein ligase Mdm2 phosphorylated 4 (human)
hMDM2/Phos:4
"An E3 ubiquitin-protein ligase Mdm2 (human) that has been post-translationally modified to include phosphoserine at positions 166, 188, 386, 395 and 407, and phosphothreonine at position 419 of the amino acid sequence represented by UniProtKB:Q00987. UniProtKB:Q00987, Ser-166/Ser-188/Ser-386/Ser-395/Ser-407, MOD:00046|Thr-419, MOD:00047." [PRO:DNx, Reactome:R-HSA-6804954]

organism-modification


PR:000048360
E3 ubiquitin-protein ligase Mdm2 ubiquitinated form (human)
hMDM2/UbiqLys+
"An E3 ubiquitin-protein ligase Mdm2 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q00987, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782472]

organism-modification


PR:000064768
E3 ubiquitin-protein ligase Mdm2 phosphorylated and ubiquitinated 1 (human)
hMDM2/PhosUbiq:1
"An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-166 and Ser-188 of the amino acid sequence represented by UniProtKB:Q00987-1 and that includes at least one ubiquitinated lysine. Example: UniProtKB:Q00987-1, Ser-166/Ser-188, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-6795669]

organism-modification


PR:000056835
E3 ubiquitin-protein ligase Mdm2 N-glycosylated 1 (human)
hMDM2/NGlyco:1
"An E3 ubiquitin-protein ligase Mdm2 (human) that has been N-glycosylated at the residue equivalent to Asn-349 of the amino acid sequence represented by UniProtKB:Q00987-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:Q00987-1, Asn-349, MOD:00160~GNO:G00912UN." [GlyGen:Q00987-1, PMID:29671580, PRO:DNx]

organism-modification


PR:000064645
E3 ubiquitin-protein ligase Mdm2 sumoylated 1 (human)
hMDM2/Sumo:1
"An E3 ubiquitin-protein ligase Mdm2 (human) that has been sumoylated on the residue at the position equivalent to Lys-182 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Lys-182, MOD:01149." [PRO:DNx, Reactome:R-HSA-3000408]

organism-modification


PR:000075214
E3 ubiquitin-protein ligase Mdm2 phosphorylated 5 (human)
hMDM2/Phos:5
"An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-190 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Ser-190, MOD:00046." [IEDB_epitope:2142541, PRO:DNx]

organism-modification


PR:000079554
E3 ubiquitin-protein ligase Mdm2 phosphorylated 6 (human)
hMDM2/Phos:6
"An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-188 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Ser-188, MOD:00046." [IEDB_epitope:2142540, PRO:DNx]

organism-modification


PR:000083276
E3 ubiquitin-protein ligase Mdm2 phosphorylated 7 (human)
hMDM2/Phos:7
"An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-186 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Ser-186, MOD:00046." [IEDB_epitope:2142539, PRO:DNx]