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Protein Ontology report - Toll/interleukin-1 receptor domain-containing adapter protein (human)
PR:P58753 - http://purl.obolibrary.org/obo/PR_P58753
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P58753   
  PRO nameToll/interleukin-1 receptor domain-containing adapter protein (human) 
  Synonyms
PRO-Short-label: EXACT:hTIRAP
Gene-based: RELATED:MAL | TIRAP
Other: EXACT:adaptor protein Wyatt (human) | MyD88 adapter-like protein (human) | MyD88-2 (human) | TIR domain-containing adapter protein (human)
  Definition"A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-gene 
  ParentPR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:17192 TIRAP (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P58753
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P58753
Toll/interleukin-1 receptor domain-containing adapter protein (human)
hTIRAP
"A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human." [PRO:CNA]

Yes
organism-sequence


PR:P58753-1
Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human)
hTIRAP/iso:1
"A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes
organism-modification


PR:000027214
Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human)
hTIRAP/iso:1/Phos:1
"A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 in human. UniProtKB:P58753-1, (Tyr-86, MOD:00048 or Tyr-106, MOD:00048 or Tyr-159, MOD:00048)." [PMID:16439361, PMID:18070880, PRO:CNA]

Yes
organism-sequence


PR:P58753-2
Toll/interleukin-1 receptor domain-containing adapter protein isoform 2 (human)
hTIRAP/iso:2
"A Toll/interleukin-1 receptor domain-containing adapter protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P58753-2." [PRO:CNA, UniProtKB:P58753]
Yes
organism-sequence


PR:P58753-3
Toll/interleukin-1 receptor domain-containing adapter protein isoform h3 (human)
hTIRAP/iso:h3
"A Toll/interleukin-1 receptor domain-containing adapter protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P58753-3." [PRO:DNx, UniProtKB:P58753]

organism-modification


PR:000049460
Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated 2 (human)
hTIRAP/Phos:2
"A Toll/interleukin-1 receptor domain-containing adapter protein (human) that has been post-translationally modified to include phosphotyrosine at positions 86, 106, 159 and 187 of the amino acid sequence represented by UniProtKB:P58753. UniProtKB:P58753, Tyr-86/Tyr-106/Tyr-159/Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-2201321]

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hTIRAP forms found in complexes   

hTIRAP Component
 Complexes
PR:000027214 hTIRAP/iso:1/Phos:1 PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P58753 hTIRAP PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:000036014 TIRAP:PIP2 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P58753ZDASHZ1 hTIRAP/iso:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P58753-2 hTIRAP/iso:2 enablesGO:0005546 phosphatidylinositol-4,5-bisphosphate binding PMID:24529375