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Protein Ontology report - serine/threonine-protein kinase PLK1 (human)
PR:P53350 - http://purl.obolibrary.org/obo/PR_P53350
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P53350   
  PRO nameserine/threonine-protein kinase PLK1 (human) 
  Synonyms
PRO-Short-label: EXACT:hPLK1
Gene-based: RELATED:PLK | PLK1
Other: EXACT:PLK-1 (human) | Polo-like kinase 1 (human) | STPK13 (human)
  Definition"A serine/threonine-protein kinase PLK1 that is encoded in the genome of human." [PMID:16129782, PMID:16580887, PMID:16760428, PMID:17376779, PMID:20624902, PMID:20823832, PRO:KER] 
  PRO Categoryorganism-gene 
  ParentPR:000012870 serine/threonine-protein kinase PLK1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:9077 PLK1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P53350
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P53350 serine/threonine-protein kinase PLK1 (human)
hPLK1
Yes
Yes
organism-sequence


PR:P53350-1 serine/threonine-protein kinase PLK1 isoform 1 (human)
hPLK1/iso:1

organism-modification


PR:000035669 serine/threonine-protein kinase PLK1 unphosphorylated form (human)
hPLK1/PhosRes-

organism-modification


PR:000044818 serine/threonine-protein kinase PLK1 phosphorylated 1 (human)
hPLK1/Phos:1
Yes
organism-modification


PR:000045826 serine/threonine-protein kinase PLK1 phosphorylated 2 (human)
hPLK1/Phos:2

organism-modification


PR:000048813 serine/threonine-protein kinase PLK1 phosphorylated 3 (human)
hPLK1/Phos:3

organism-modification


PR:000068734 serine/threonine-protein kinase PLK1 methylated 1 (human)
hPLK1/Me:1

organism-modification


PR:000075930 serine/threonine-protein kinase PLK1 deaminated 1 (human)
hPLK1/Deam:1

organism-modification


PR:000076381 serine/threonine-protein kinase PLK1 methylated 2 (human)
hPLK1/Me:2

organism-modification


PR:000083595 serine/threonine-protein kinase PLK1 cysteinylated 1 (human)
hPLK1/Cyst:1

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hPLK1 forms found in complexes   

hPLK1 Component
 Complexes
PR:P53350 hPLK1 PR:000035581 phosphoBUB1:PLK1 complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007091 metaphase/anaphase transition of mitotic cell cyclePR:000044818 hPLK1/Phos:1 PMID:23695676
GO:0008608 attachment of spindle microtubules to kinetochorePR:P53350 hPLK1 PMID:17376779
NOT GO:0031577 spindle checkpoint signalingPR:P53350 hPLK1 PMID:16760428
GO:0034092 negative regulation of maintenance of sister chromatid cohesionPR:P53350 hPLK1 PMID:16580887
NOT GO:0034501 protein localization to kinetochorePR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
PR:P53350 hPLK1 PMID:16760428
GO:0051310 metaphase chromosome alignmentPR:P53350 hPLK1 PMID:17376779

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004672 protein kinase activityPR:P53350 hPLK1 PMID:16760428
GO:0005515 protein bindingPR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
PR:P53350 hPLK1 BioGRID:BG-338598
GO:0071889 14-3-3 protein bindingPR:000044818 hPLK1/Phos:1 PMID:23695676

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0000776 kinetochorePR:P53350 hPLK1 PMID:20624902
GO:0000922 spindle polePR:P53350 hPLK1 PMID:20823832
GO:0000940 outer kinetochorePR:P53350 hPLK1 PMID:16760428
GO:0005813 centrosomePR:P53350 hPLK1 PMID:16760428