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Protein Ontology report - interleukin-1 receptor-associated kinase 1 (human)
PR:P51617 - http://purl.obolibrary.org/obo/PR_P51617
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P51617   
  PRO nameinterleukin-1 receptor-associated kinase 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hIRAK1
Gene-based: RELATED:IRAK | IRAK1
Other: EXACT:IRAK-1 (human)
  Definition"An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-gene 
  ParentPR:000001782 interleukin-1 receptor-associated kinase 1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:6112 IRAK1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P51617
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:P51617

interleukin-1 receptor-associated kinase 1 (human)

hIRAK1


"An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P51617-1

interleukin-1 receptor-associated kinase 1 isoform 1 (human)

hIRAK1/iso:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000027492

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)

hIRAK1/iso:1/Phos:3


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA]

Yes

organism-modification



PR:000027493

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)

hIRAK1/iso:1/Phos:4


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046." [PMID:14625308, PRO:CNA]

Yes

organism-modification



PR:000027494

interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)

hIRAK1/iso:1/Phos:1


"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P51617-1, Thr-209, MOD:00047." [PRO:DNx, UniProtKB:P51617]

Yes

Yes
organism-modification



PR:000061935

interleukin-1 receptor-associated kinase 1 isoform 1 phosphoserine and phosphothreonine form (human)

hIRAK1/iso:1/pSerThr+


"An interleukin-1 receptor-associated kinase 1 isoform 1 (human) that includes at least one phosphorylated serine and at least one phosphorylated threonine. UniProtKB:P51617-1, MOD:00046|MOD:00047." [PRO:DNx, Reactome:R-HSA-193904]


organism-sequence



PR:P51617-2

interleukin-1 receptor-associated kinase 1 isoform h2 (human)

hIRAK1/iso:h2


"An interleukin-1 receptor-associated kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-2." [PRO:DNx, UniProtKB:P51617]


organism-sequence



PR:P51617-3

interleukin-1 receptor-associated kinase 1 isoform h3 (human)

hIRAK1/iso:h3


"An interleukin-1 receptor-associated kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-3." [PRO:DNx, UniProtKB:P51617]


organism-sequence



PR:P51617-4

interleukin-1 receptor-associated kinase 1 isoform h4 (human)

hIRAK1/iso:h4


"An interleukin-1 receptor-associated kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-4." [PRO:DNx, UniProtKB:P51617]


organism-modification



PR:000048042

interleukin-1 receptor-associated kinase 1 phosphorylated 5 (human)

hIRAK1/Phos:5


"An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-376, and phosphothreonine at position 387 of the amino acid sequence represented by UniProtKB:P51617. UniProtKB:P51617, Ser-376, MOD:00046|Thr-387, MOD:00047." [PRO:DNx, Reactome:R-HSA-446687]


organism-modification



PR:000048043

interleukin-1 receptor-associated kinase 1 phosphorylated 1 (human)

hIRAK1/Phos:1


"An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-209 of the amino acid sequence represented by UniProtKB:P51617. UniProtKB:P51617, Thr-209, MOD:00047." [PRO:DNx, Reactome:R-HSA-937031, Reactome:R-HSA-975189]


organism-modification



PR:000048044

interleukin-1 receptor-associated kinase 1 phosphorylated 3 (human)

hIRAK1/Phos:3


"An interleukin-1 receptor-associated kinase 1 (human) that has been post-translationally modified to include phosphothreonine at positions 209 and 387 of the amino acid sequence represented by UniProtKB:P51617. UniProtKB:P51617, Thr-209/Thr-387, MOD:00047." [PRO:DNx, Reactome:R-HSA-166279, Reactome:R-HSA-975117]


organism-modification



PR:000062298

interleukin-1 receptor-associated kinase 1 phosphorylated 2 (human)

hIRAK1/Phos:2


"An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-209, Ser-376, and Thr-387 of the amino acid sequence represented by UniProtKB:P51617-1 and that includes at least one additional phosphorylated threonine and at least two additional phosphorylated serines. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|Ser-376, MOD:00046|MOD:00046(2+)|MOD:00047." [PRO:DNx, Reactome:R-HSA-446682, Reactome:R-HSA-937011, Reactome:R-HSA-975157]


organism-modification



PR:000064197

interleukin-1 receptor-associated kinase 1 phosphoserine and phosphothreonine form (human)

hIRAK1/pSerThr+


"An interleukin-1 receptor-associated kinase 1 (human) that includes at least one phosphorylated serine and at least one phosphorylated threonine. UniProtKB:P51617, MOD:00046|MOD:00047." [PRO:DNx, Reactome:R-HSA-3149574]


organism-modification



PR:000064772

interleukin-1 receptor-associated kinase 1 phosphorylated and ubiquitinated 1 (human)

hIRAK1/PhosUbiq:1


"An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-209, Ser-376 and Thr-387, and ubiquitinated on the residues at the positions equivalent to Lys-134 and Lys-180 of the amino acid sequence represented by UniProtKB:P51617-1 and that includes at least one additional phosphorylated threonine and at least two additional phosphorylated serines. Example: UniProtKB:P51617-1, Lys-134/Lys-180, MOD:01148|Thr-209/Thr-387, MOD:00047|Ser-376, MOD:00046|MOD:00046(2+)|MOD:00047." [PRO:DNx, Reactome:R-HSA-975112]


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hIRAK1 forms found in complexes   

hIRAK1 Component
Complexes
PR:000027494 hIRAK1/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027492 hIRAK1/iso:1/Phos:3
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047
acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308
PR:000027493 hIRAK1/iso:1/Phos:4
UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046
acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0004674 protein serine/threonine kinase activity PMID:14625308
NOT GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
NOT GO:0005515 protein binding PMID:14625308
PR:000027494 hIRAK1/iso:1/Phos:1
UniProtKB:P51617-1, Thr-209, MOD:00047
enablesGO:0005515 protein binding with PR:Q9NWZ3 hIRAK4 PMID:11960013
GO:0016301 kinase activity PMID:11960013
PR:P51617-1 hIRAK1/iso:1 acts_upstream_of_or_withinGO:0070498 interleukin-1-mediated signaling pathway PMID:14625308
enablesGO:0005515 protein binding with PR:Q99836 hMYD88 PMID:14625308
GO:0005515 protein binding with PR:Q9Y4K3 E3 ubiquitin-protein ligase TRAF6 (human) PMID:14625308