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Protein Ontology report - cartilage oligomeric matrix protein (human)
PR:P49747 - http://purl.obolibrary.org/obo/PR_P49747
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P49747   
  PRO namecartilage oligomeric matrix protein (human) 
  Synonyms
PRO-Short-label: EXACT:hCOMP
Gene-based: RELATED:COMP
Other: EXACT:thrombospondin-5 (human) | TSP5 (human)
  Definition"A cartilage oligomeric matrix protein that is encoded in the genome of human." [PRO:CNA, UniProtKB:P49747] 
  PRO Categoryorganism-gene 
  ParentPR:000000085 cartilage oligomeric matrix protein
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:2227 COMP (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 35                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P49747
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P49747
cartilage oligomeric matrix protein (human)
hCOMP
"A cartilage oligomeric matrix protein that is encoded in the genome of human." [PRO:CNA, UniProtKB:P49747]

organism-sequence


PR:000000231
cartilage oligomeric matrix protein sequence variant P276R (human)
hCOMP/var:P276R
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Pro-276 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Pro-276, CHEBI:29952." [PMID:11565064, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000232
cartilage oligomeric matrix protein sequence variant C387G (human)
hCOMP/var:C387G
"A cartilage oligomeric matrix protein (human) that has a Gly residue at the position equivalent to Cys-387 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-387, CHEBI:29947." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000233
cartilage oligomeric matrix protein sequence variant D408Y (human)
hCOMP/var:D408Y
"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-408 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-408, CHEBI:46858." [PMID:9452026, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000234
cartilage oligomeric matrix protein sequence variant D420A (human)
hCOMP/var:D420A
"A cartilage oligomeric matrix protein (human) that has an Ala residue at the position equivalent to Asp-420 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-420, CHEBI:46217." [PMID:11565064, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000235
cartilage oligomeric matrix protein sequence variant G440E (human)
hCOMP/var:G440E
"A cartilage oligomeric matrix protein (human) that has a Glu residue at the position equivalent to Gly-440 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-440, CHEBI:29972." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000236
cartilage oligomeric matrix protein sequence variant G440R (human)
hCOMP/var:G440R
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Gly-440 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-440, CHEBI:29952." [PMID:9452026, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000237
cartilage oligomeric matrix protein sequence variant N453S (human)
hCOMP/var:N453S
"A cartilage oligomeric matrix protein (human) that has a Ser residue at the position equivalent to Asn-453 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asn-453, CHEBI:29999." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000238
cartilage oligomeric matrix protein sequence variant D439V (human)
hCOMP/var:D439V
"A cartilage oligomeric matrix protein (human) that has a Val residue at the position equivalent to Asp-439 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-439, CHEBI:30015." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000239
cartilage oligomeric matrix protein sequence variant C468Y (human)
hCOMP/var:C468Y
"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Cys-468 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-468, CHEBI:46858." [PMID:7670471, PMID:9452026, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000240
cartilage oligomeric matrix protein sequence variant D472Y (human)
hCOMP/var:D472Y
"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-472 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-472, CHEBI:46858." [PMID:7670471, PMID:9452026, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000241
cartilage oligomeric matrix protein sequence variant D473G (human)
hCOMP/var:D473G
"A cartilage oligomeric matrix protein (human) that has a Gly residue at the position equivalent to Asp-473 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-473, CHEBI:29947." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000242
cartilage oligomeric matrix protein sequence variant D290N (human)
hCOMP/var:D290N
"A cartilage oligomeric matrix protein (human) that has an Asn residue at the position equivalent to Asp-290 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-290, CHEBI:50347." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000243
cartilage oligomeric matrix protein sequence variant D482G (human)
hCOMP/var:D482G
"A cartilage oligomeric matrix protein (human) that has a Gly residue at the position equivalent to Asp-482 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-482, CHEBI:29947." [PMID:9452063, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000244
cartilage oligomeric matrix protein sequence variant D518N (human)
hCOMP/var:D518N
"A cartilage oligomeric matrix protein (human) that has an Asn residue at the position equivalent to Asp-518 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-518, CHEBI:50347." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000245
cartilage oligomeric matrix protein sequence variant G719D (human)
hCOMP/var:G719D
"A cartilage oligomeric matrix protein (human) that has an Asp residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-719, CHEBI:29958." [PMID:11746044, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000246
cartilage oligomeric matrix protein sequence variant N523K (human)
hCOMP/var:N523K
"A cartilage oligomeric matrix protein (human) that has a Lys residue at the position equivalent to Asn-523 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asn-523, CHEBI:29967." [PMID:9021009, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000247
cartilage oligomeric matrix protein sequence variant T585M (human)
hCOMP/var:T585M
"A cartilage oligomeric matrix protein (human) that has a Met residue at the position equivalent to Thr-585 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Thr-585, CHEBI:16044." [PMID:11565064, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000248
cartilage oligomeric matrix protein sequence variant T585R (human)
hCOMP/var:T585R
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Thr-585 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Thr-585, CHEBI:29952." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000249
cartilage oligomeric matrix protein sequence variant 26 (human)
hCOMP/var:26
"A cartilage oligomeric matrix protein (human) that has a Val residue at the position equivalent to region 391-394 of the amino acid sequence represented by UniProtKB:P49747-1." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000250
cartilage oligomeric matrix protein sequence variant D372del (human)
hCOMP/var:D372del
"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-372 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-371, 373-757." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000251
cartilage oligomeric matrix protein sequence variant D374del (human)
hCOMP/var:D374del
"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-374 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-373, 375-757." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000252
cartilage oligomeric matrix protein sequence variant S459del (human)
hCOMP/var:S459del
"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Ser-459 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-458, 460-757." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000253
cartilage oligomeric matrix protein sequence variant G299R (human)
hCOMP/var:G299R
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Gly-299 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-299, CHEBI:29952." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000254
cartilage oligomeric matrix protein sequence variant D469del (human)
hCOMP/var:D469del
"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-469 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-468, 470-757." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000255
cartilage oligomeric matrix protein sequence variant D473del (human)
hCOMP/var:D473del
"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-473 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-472, 474-757." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000256
cartilage oligomeric matrix protein sequence variant 32 (human)
hCOMP/var:32
"A cartilage oligomeric matrix protein (human) that has a two-residue deletion at the positions equivalent to region 367-368 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-366, 369-757." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000257
cartilage oligomeric matrix protein sequence variant 33 (human)
hCOMP/var:33
"A cartilage oligomeric matrix protein (human) that has a four-residue deletion at the positions equivalent to region 513-516 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-512, 517-757." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000258
cartilage oligomeric matrix protein sequence variant C328R (human)
hCOMP/var:C328R
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Cys-328 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-328, CHEBI:29952." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000259
cartilage oligomeric matrix protein sequence variant D342Y (human)
hCOMP/var:D342Y
"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-342 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-342, CHEBI:46858." [PMID:7670472, PMID:9452026, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000260
cartilage oligomeric matrix protein sequence variant C348R (human)
hCOMP/var:C348R
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Cys-348 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-348, CHEBI:29952." [PMID:11746045, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000261
cartilage oligomeric matrix protein sequence variant D361V (human)
hCOMP/var:D361V
"A cartilage oligomeric matrix protein (human) that has a Val residue at the position equivalent to Asp-361 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-361, CHEBI:30015." [PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000262
cartilage oligomeric matrix protein sequence variant D361Y (human)
hCOMP/var:D361Y
"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-361 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-361, CHEBI:46858." [PMID:9452027, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000263
cartilage oligomeric matrix protein sequence variant C371S (human)
hCOMP/var:C371S
"A cartilage oligomeric matrix protein (human) that has a Ser residue at the position equivalent to Cys-371 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-371, CHEBI:29999." [PMID:9184241, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:P49747-1
cartilage oligomeric matrix protein isoform 1 (human)
hCOMP/iso:1
"A cartilage oligomeric matrix protein isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036452
cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)
hCOMP/iso:1/SigPep-
"A cartilage oligomeric matrix protein isoform 1, signal peptide removed form in human. UniProtKB:P49747-1, 21-757." [PMID:7670472, PMID:7713493, PMID:9749943, PRO:CNA]
Yes
organism-sequence


PR:P49747-2
cartilage oligomeric matrix protein isoform h2 (human)
hCOMP/iso:h2
"A cartilage oligomeric matrix protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49747-2." [PRO:DNx, UniProtKB:P49747]

organism-modification


PR:000056586
cartilage oligomeric matrix protein N-glycosylated 1 (human)
hCOMP/NGlyco:1
"A cartilage oligomeric matrix protein (human) that has been N-glycosylated at the residue equivalent to Asn-121 of the amino acid sequence represented by UniProtKB:P49747-1, in which the glycan composition is represented by GlyTouCan:G83555HU. Example: UniProtKB:P49747-1, Asn-121, MOD:00160~GNO:G83555HU." [GlyGen:P49747-1, PMID:29671580, PRO:DNx]

organism-modification


PR:000056587
cartilage oligomeric matrix protein N-glycosylated 2 (human)
hCOMP/NGlyco:2
"A cartilage oligomeric matrix protein (human) that has been N-glycosylated at the residue equivalent to Asn-742 of the amino acid sequence represented by UniProtKB:P49747-1, in which the glycan composition is represented by GlyTouCan:G80920RR. Example: UniProtKB:P49747-1, Asn-742, MOD:00160~GNO:G80920RR." [GlyGen:P49747-1, PMID:29671580, PRO:DNx]

organism-modification


PR:000068189
cartilage oligomeric matrix protein deaminated 1 (human)
hCOMP/Deam:1
"A cartilage oligomeric matrix protein (human) that has been deaminated on the residue at the position equivalent to Asn-123 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asn-123, MOD:00684." [IEDB_epitope:167687, PRO:DNx]

organism-modification


PR:000073868
cartilage oligomeric matrix protein deaminated 2 (human)
hCOMP/Deam:2
"A cartilage oligomeric matrix protein (human) that has been deaminated on the residue at the position equivalent to Asn-78 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asn-78, MOD:00684." [IEDB_epitope:167500, PRO:DNx]

organism-modification


PR:000085876
cartilage oligomeric matrix protein, signal peptide removed form (human)
hCOMP/SigPep-
"A cartilage oligomeric matrix protein (human) that has had the signal peptide removed. Example: UniProtKB:P49747-1, 21-757." [PRO:DNx, Reactome:R-HSA-2426331]

organism-modification


PR:000036452
cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)
hCOMP/iso:1/SigPep-
"A cartilage oligomeric matrix protein isoform 1, signal peptide removed form in human. UniProtKB:P49747-1, 21-757." [PMID:7670472, PMID:7713493, PMID:9749943, PRO:CNA]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001501 skeletal system developmentPR:P49747-1 hCOMP/iso:1 PMID:7670472
GO:0009887 animal organ morphogenesisPR:000036452 hCOMP/iso:1/SigPep- PMID:7713493
PR:P49747-1 hCOMP/iso:1 PMID:7713493

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0080047 pseudoachondroplasiaPR:000000232 hCOMP/var:C387G UniProtKB_VAR:VAR_007625
PR:000000235 hCOMP/var:G440E UniProtKB_VAR:VAR_007628
PR:000000236 hCOMP/var:G440R PMID:9452026
PR:000000238 hCOMP/var:D439V UniProtKB_VAR:VAR_007618
PR:000000239 hCOMP/var:C468Y PMID:7670471; PMID:9452026
PR:000000240 hCOMP/var:D472Y PMID:7670471; PMID:9452026
PR:000000241 hCOMP/var:D473G UniProtKB_VAR:VAR_007635
PR:000000242 hCOMP/var:D290N UniProtKB_VAR:VAR_007614
PR:000000243 hCOMP/var:D482G PMID:9452063
PR:000000244 hCOMP/var:D518N UniProtKB_VAR:VAR_007639
PR:000000245 hCOMP/var:G719D PMID:11746044
PR:000000247 hCOMP/var:T585M PMID:11565064
PR:000000249 hCOMP/var:26 UniProtKB_VAR:VAR_007626
PR:000000250 hCOMP/var:D372del UniProtKB_VAR:VAR_007623
PR:000000251 hCOMP/var:D374del UniProtKB_VAR:VAR_007624
PR:000000252 hCOMP/var:S459del UniProtKB_VAR:VAR_007631
PR:000000253 hCOMP/var:G299R UniProtKB_VAR:VAR_007615
PR:000000254 hCOMP/var:D469del UniProtKB_VAR:VAR_007633
PR:000000255 hCOMP/var:D473del UniProtKB_VAR:VAR_007636
PR:000000257 hCOMP/var:33 UniProtKB_VAR:VAR_007638
PR:000000258 hCOMP/var:C328R UniProtKB_VAR:VAR_007616
PR:000000260 hCOMP/var:C348R PMID:11746045
DO:12721 multiple epiphyseal dysplasiaPR:000000231 hCOMP/var:P276R PMID:11565064
PR:000000233 hCOMP/var:D408Y PMID:9452026
PR:000000234 hCOMP/var:D420A PMID:11565064
PR:000000237 hCOMP/var:N453S UniProtKB_VAR:VAR_007630
PR:000000246 hCOMP/var:N523K PMID:9021009
PR:000000247 hCOMP/var:T585M PMID:11565064
PR:000000248 hCOMP/var:T585R UniProtKB_VAR:VAR_007642
PR:000000256 hCOMP/var:32 UniProtKB_VAR:VAR_007621
PR:000000259 hCOMP/var:D342Y PMID:7670472; PMID:9452026
PR:000000261 hCOMP/var:D361V UniProtKB_VAR:VAR_007619
PR:000000262 hCOMP/var:D361Y PMID:9452026
PR:000000263 hCOMP/var:C371S PMID:9184241

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005201 extracellular matrix structural constituentPR:000036452 hCOMP/iso:1/SigPep- PMID:9749943
GO:0005509 calcium ion bindingPR:000036452 hCOMP/iso:1/SigPep- PMID:7670472

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0031012 extracellular matrixPR:000036452 hCOMP/iso:1/SigPep- PMID:9749943