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Protein Ontology report - transcriptional coactivator YAP1 (human)
PR:P46937 - http://purl.obolibrary.org/obo/PR_P46937
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P46937   
  PRO nametranscriptional coactivator YAP1 (human) 
  Synonyms
PRO-Short-label: EXACT:hYAP1
Gene-based: RELATED:YAP1 | YAP65
Other: EXACT:protein yorkie homolog (human) | Yes-associated protein 1 (human) | Yes-associated protein YAP65 homolog (human)
  Definition"A transcriptional coactivator YAP1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P46937] 
  PRO Categoryorganism-gene 
  ParentPR:000017522 transcriptional coactivator YAP1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:16262 YAP1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 9                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P46937
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P46937
transcriptional coactivator YAP1 (human)
hYAP1
"A transcriptional coactivator YAP1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P46937]

organism-sequence


PR:P46937-1
transcriptional coactivator YAP1 isoform h1 (human)
hYAP1/iso:h1
"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-1." [PRO:DNx, UniProtKB:P46937]

organism-sequence


PR:P46937-2
transcriptional coactivator YAP1 isoform h2 (human)
hYAP1/iso:h2
"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-2." [PRO:DNx, UniProtKB:P46937]

organism-sequence


PR:P46937-3
transcriptional coactivator YAP1 isoform 3 (human)
hYAP1/iso:3
"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-3." [PRO:DNx, UniProtKB:P46937]

organism-modification


PR:000037507
transcriptional coactivator YAP1 isoform 3 unphosphorylated 1 (human)
hYAP1/iso:3/UnPhos:1
"A transcriptional coactivator YAP1 isoform 3 (human) that lacks a phosphorylated Tyr residue at position 357. UniProtKB:P46937-3, Tyr-357, PR:000026291." [PMID:21214929, PMID:21945154, PRO:KER]
Yes
organism-modification


PR:000037508
transcriptional coactivator YAP1 isoform 3 phosphorylated 1 (human)
hYAP1/iso:3/Phos:1
"A transcriptional coactivator YAP1 isoform 3 (human) that has been phosphorylated on a Tyr residue at position 357. UniProtKB:P46937-3, Tyr-357, MOD:00048." [PMID:21214929, PMID:21945154, PRO:KER]
Yes
organism-sequence


PR:P46937-4
transcriptional coactivator YAP1 isoform h4 (human)
hYAP1/iso:h4
"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-4." [PRO:DNx, UniProtKB:P46937]

organism-sequence


PR:P46937-5
transcriptional coactivator YAP1 isoform h5 (human)
hYAP1/iso:h5
"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-5." [PRO:DNx, UniProtKB:P46937]

organism-sequence


PR:P46937-6
transcriptional coactivator YAP1 isoform h6 (human)
hYAP1/iso:h6
"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-6." [PRO:DNx, UniProtKB:P46937]

organism-sequence


PR:P46937-7
transcriptional coactivator YAP1 isoform h7 (human)
hYAP1/iso:h7
"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-7." [PRO:DNx, UniProtKB:P46937]

organism-sequence


PR:P46937-8
transcriptional coactivator YAP1 isoform h8 (human)
hYAP1/iso:h8
"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-8." [PRO:DNx, UniProtKB:P46937]

organism-sequence


PR:P46937-9
transcriptional coactivator YAP1 isoform h9 (human)
hYAP1/iso:h9
"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-9." [PRO:DNx, UniProtKB:P46937]

organism-modification


PR:000037509
transcriptional coactivator YAP1 unphosphorylated 1 (human)
hYAP1/UnPhos:1
"A transcriptional coactivator YAP1 (human) that lacks phosphorylation on the residue at the position equivalent to Ser-127 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Ser-127, PR:000026291." [PMID:21214929, PMID:21945154, PRO:KER]

organism-modification


PR:000037510
transcriptional coactivator YAP1 phosphorylated 1 (human)
hYAP1/Phos:1
"A transcriptional coactivator YAP1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-127 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Ser-127, MOD:00046." [PMID:20153295, PMID:21214929, PMID:21945154, PRO:KER]
Yes
organism-modification


PR:000045791
transcriptional coactivator YAP1 phosphorylated 2 (human)
hYAP1/Phos:2
"A transcriptional coactivator YAP1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-94 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Ser-94, MOD:00046." [iPTMnet:P46937, PMID:25751140]

organism-modification


PR:000049715
transcriptional coactivator YAP1 phosphorylated 3 (human)
hYAP1/Phos:3
"A transcriptional coactivator YAP1 (human) that has been post-translationally modified to include phosphoserine at positions 61, 109, 127, 164 and 397 of the amino acid sequence represented by UniProtKB:P46937. UniProtKB:P46937, Ser-61/Ser-109/Ser-127/Ser-164/Ser-397, MOD:00046." [PRO:DNx, Reactome:R-HSA-2028554]

organism-modification


PR:000063813
transcriptional coactivator YAP1 phosphotyrosine form (human)
hYAP1/PhosTyr+
"A transcriptional coactivator YAP1 (human) that includes at least one phosphorylated tyrosine. UniProtKB:P46937, MOD:00048." [PRO:DNx, Reactome:R-HSA-8937843, Reactome:R-HSA-8937857]

organism-modification


PR:000064465
transcriptional coactivator YAP1 phosphorylated 4 (human)
hYAP1/Phos:4
"A transcriptional coactivator YAP1 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-407 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Tyr-407, MOD:00048." [PRO:DNx, Reactome:R-HSA-8956661]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037507 hYAP1/iso:3/UnPhos:1
UniProtKB:P46937-3, Tyr-357, PR:000026291		 enablesGO:0005515 protein binding with PR:O15350 hTP73 PMID:21214929; PMID:21562856
PR:000037508 hYAP1/iso:3/Phos:1
UniProtKB:P46937-3, Tyr-357, MOD:00048		 associated_with_disease_progressionDO:10652 Alzheimer's disease PMID:21562856
enablesincreased GO:0005515 protein binding with PR:O15350 hTP73 PMID:21214929; PMID:21562856
located_inD162 cancer PMID:21214929
GO:0005634 nucleus PMID:21562856
PR:000037510 hYAP1/Phos:1
Example: UniProtKB:P46937-1, Ser-127, MOD:00046		 associated_with_disease_progressionDO:162 cancer PMID:21214929
enablesdecreased GO:0005515 protein binding with PR:000003237 fam:14-3-3 PMID:21945154
decreased GO:0005515 protein binding with PR:O15350 hTP73 PMID:21945154
located_inD10652 Alzheimer's disease PMID:21945154