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Protein Ontology report - cyclin-dependent kinase inhibitor 1B (human)
PR:P46527 - http://purl.obolibrary.org/obo/PR_P46527
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P46527   
  PRO namecyclin-dependent kinase inhibitor 1B (human) 
  Synonyms
PRO-Short-label: EXACT:hCDKN1B
Gene-based: RELATED:CDKN1B | KIP1 | p27
Other: EXACT:cyclin-dependent kinase inhibitor p27 (human) | p27Kip1 (human)
  Definition"A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of human." [PRO:CNA, UniProtKB:P46527
  CommentRequested by=PubChem. 
  PRO Categoryorganism-gene 
  ParentPR:000003090 cyclin-dependent kinase inhibitor 1B
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:1785 CDKN1B (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P46527
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:P46527

cyclin-dependent kinase inhibitor 1B (human)

hCDKN1B


"A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of human." [PRO:CNA, UniProtKB:P46527]


organism-sequence



PR:P46527-1

cyclin-dependent kinase inhibitor 1B isoform 1 (human)

hCDKN1B/iso:1


"A cyclin-dependent kinase inhibitor 1B isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000025750

cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 (human)

hCDKN1B/iso:1/Phos:2


"A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 2 in human. Phosphorylation at this site promotes subsequent Cdk2-mediated phosphorylation at Thr-187. UniProtKB:P46527-1, Tyr-88, MOD:00048." [PMID:17254966, PRO:JAN]

Yes

organism-modification



PR:000025752

cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3 (human)

hCDKN1B/iso:1/Phos:3


"A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 3 in human. UniProtKB:P46527-1, Tyr-88, MOD:00048|Thr-187, MOD:00047." [PMID:17254966, PRO:CNA]


organism-modification



PR:000036634

cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1 (human)

hCDKN1B/iso:1/Phos:1


"A cyclin-dependent kinase inhibitor 1B isoform 1 phosphorylated 1 in human. UniProtKB:P46527-1, Thr-157, MOD:00047." [PMID:12244301, PMID:15057270, PRO:JAN]

Yes

organism-modification



PR:000045370

cyclin-dependent kinase inhibitor 1B isoform 1 unphosphorylated 2 (human)

hCDKN1B/iso:1/UnPhos:2


"A cyclin-dependent kinase inhibitor 1B isoform 1 (human) that lacks phosphorylation at Tyr-88. UniProtKB:P46527-1, Tyr-88, PR:000026291." [PRO:CNA]

Yes

organism-modification



PR:000045790

cyclin-dependent kinase inhibitor 1B phosphorylated 1 (human)

hCDKN1B/Phos:1


"A cyclin-dependent kinase inhibitor 1B (human) that has been phosphorylated at Thr-198. UniProtKB:P46527, Thr-198, MOD:00047." [iPTMnet:P46527, PMID:15280662]


organism-modification



PR:000046682

cyclin-dependent kinase inhibitor 1B phosphorylated 4 (human)

hCDKN1B/Phos:4


"A cyclin-dependent kinase inhibitor 1B (human) that has been phosphorylated on the residue at the position equivalent to Thr-187 of the amino acid sequence represented by UniProtKB:P46527. UniProtKB:P46527, Thr-187, MOD:00047." [PRO:DNx, Reactome:R-HSA-187525]


organism-modification



PR:000046683

cyclin-dependent kinase inhibitor 1B phosphorylated 2 (human)

hCDKN1B/Phos:2


"A cyclin-dependent kinase inhibitor 1B (human) that has been phosphorylated on the residue at the position equivalent to Tyr-88 of the amino acid sequence represented by UniProtKB:P46527. UniProtKB:P46527, Tyr-88, MOD:00048." [PRO:DNx, Reactome:R-HSA-8848438]


organism-modification



PR:000060524

cyclin-dependent kinase inhibitor 1B phosphorylated 3 (human)

hCDKN1B/Phos:3


"A cyclin-dependent kinase inhibitor 1B (human) that has been phosphorylated on the residue at the position equivalent to Ser-10 of the amino acid sequence represented by UniProtKB:P46527. UniProtKB:P46527, Ser-10, MOD:00046." [PRO:DNx, Reactome:R-HSA-9632829, Reactome:R-HSA-9632832]


organism-modification



PR:000062722

cyclin-dependent kinase inhibitor 1B phosphorylated 5 (human)

hCDKN1B/Phos:5


"A cyclin-dependent kinase inhibitor 1B (human) that has been phosphorylated on the residue at the position equivalent to Thr-157 of the amino acid sequence represented by UniProtKB:P46527. UniProtKB:P46527, Thr-157, MOD:00047." [PRO:DNx, Reactome:R-HSA-198629]


organism-modification



PR:000073909

cyclin-dependent kinase inhibitor 1B methylated 1 (human)

hCDKN1B/Me:1


"A cyclin-dependent kinase inhibitor 1B (human) that has been methylated on the residue at the position equivalent to Cys-29 of the amino acid sequence represented by UniProtKB:P46527. UniProtKB:P46527, Cys-29, MOD:00660." [IEDB_epitope:1018732, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025750 hCDKN1B/iso:1/Phos:2
UniProtKB:P46527-1, Tyr-88, MOD:00048
acts_upstream_of_or_withinGO:0051318 G1 phase PMID:17254966
enablesdecreased GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity relative to PR:000045370 hCDKN1B/iso:1/UnPhos:2 PMID:17254966
GO:0005515 protein binding with PR:P24385 B-cell lymphoma 1 protein (human) PMID:17254966
GO:0005515 protein binding with PR:P24864 CCNE PMID:17254966
GO:0005515 protein binding PMID:17254966
GO:0044877 protein-containing complex binding PMID:17254966
PR:000036634 hCDKN1B/iso:1/Phos:1
UniProtKB:P46527-1, Thr-157, MOD:00047
acts_upstream_of_or_withinGO:0008284 positive regulation of cell population proliferation PMID:12244301
enablesdecreased GO:0005515 protein binding with PR:P31946 hYWHAB PMID:15057270
decreased GO:0005515 protein binding with PR:P61981 hYWHAG PMID:15057270
decreased GO:0005515 protein binding with PR:P62258 14-3-3E (human) PMID:15057270
decreased GO:0005515 protein binding with PR:P52294 hKPNA1 PMID:15057270
located_inGO:0005737 cytoplasm PMID:15057270
GO:0005829 cytosol PMID:12244301
PR:000045370 hCDKN1B/iso:1/UnPhos:2
UniProtKB:P46527-1, Tyr-88, PR:000026291
acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:12244301
GO:0051318 G1 phase PMID:17254966
enablesGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity PMID:17254966
GO:0005515 protein binding PMID:12244301
GO:0044877 protein-containing complex binding PMID:17254966
located_inGO:0005634 nucleus PMID:12244301