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Protein Ontology report - TGF-beta receptor type-2 (human)
PR:P37173 - http://purl.obolibrary.org/obo/PR_P37173
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P37173   
  PRO nameTGF-beta receptor type-2 (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFBR2
Gene-based: RELATED:TGFBR2
Other: EXACT:TbetaR-II (human) | TGF-beta receptor type II (human) | TGF-beta type II receptor (human) | TGFR-2 (human) | transforming growth factor-beta receptor type II (human)
  Definition"A TGF-beta receptor type-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P37173] 
  PRO Categoryorganism-gene 
  ParentPR:000000005 TGF-beta receptor type-2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11773 TGFBR2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 19                                        
         Modification0                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P37173
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P37173 TGF-beta receptor type-2 (human)
hTGFBR2

organism-sequence


PR:000000050 TGF-beta receptor type-2 sequence variant L308P (human)
hTGFBR2/var:L308P
Yes
organism-sequence


PR:000000051 TGF-beta receptor type-2 sequence variant R460H (human)
hTGFBR2/var:R460H
Yes
organism-sequence


PR:000000052 TGF-beta receptor type-2 sequence variant R460C (human)
hTGFBR2/var:R460C
Yes
organism-sequence


PR:000000053 TGF-beta receptor type-2 sequence variant E526Q (human)
hTGFBR2/var:E526Q
Yes
organism-sequence


PR:000000054 TGF-beta receptor type-2 sequence variant R528C (human)
hTGFBR2/var:R528C
Yes
organism-sequence


PR:000000055 TGF-beta receptor type-2 sequence variant R528H (human)
hTGFBR2/var:R528H
Yes
organism-sequence


PR:000000056 TGF-beta receptor type-2 sequence variant R537C (human)
hTGFBR2/var:R537C
Yes
organism-sequence


PR:000000057 TGF-beta receptor type-2 sequence variant G357W (human)
hTGFBR2/var:G357W
Yes
organism-sequence


PR:000000058 TGF-beta receptor type-2 sequence variant T315M (human)
hTGFBR2/var:T315M
Yes
organism-sequence


PR:000000059 TGF-beta receptor type-2 sequence variant Y336N (human)
hTGFBR2/var:Y336N
Yes
organism-sequence


PR:000000060 TGF-beta receptor type-2 sequence variant A355P (human)
hTGFBR2/var:A355P
Yes
organism-sequence


PR:000000061 TGF-beta receptor type-2 sequence variant V387M (human)
hTGFBR2/var:V387M
Yes
organism-sequence


PR:000000062 TGF-beta receptor type-2 sequence variant N435S (human)
hTGFBR2/var:N435S
Yes
organism-sequence


PR:000000063 TGF-beta receptor type-2 sequence variant V447A (human)
hTGFBR2/var:V447A
Yes
organism-sequence


PR:000000064 TGF-beta receptor type-2 sequence variant S449F (human)
hTGFBR2/var:S449F
Yes
organism-sequence


PR:000000065 TGF-beta receptor type-2 sequence variant L452M (human)
hTGFBR2/var:L452M
Yes
organism-sequence


PR:P37173-1 TGF-beta receptor type-2 isoform RII-1 (human)
hTGFBR2/iso:RII-1

organism-modification


PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-sequence


PR:P37173-2 TGF-beta receptor type-2 isoform RII-2 (human)
hTGFBR2/iso:RII-2
Yes
organism-sequence


PR:P37173-3 TGF-beta receptor type-2 isoform h3 (human)
hTGFBR2/iso:h3

organism-modification


PR:000085798 TGF-beta receptor type-2, signal peptide removed form (human)
hTGFBR2/SigPep-

organism-modification


PR:000036408 TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification


PR:000025962 TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1

Yes
organism-modification


PR:000049434 TGF-beta receptor type-2, signal peptide removed neddylated 1 (human)
hTGFBR2/SigPep-/Nedd:1

organism-modification


PR:000060724 TGF-beta receptor type-2 sequence variant Y470D, signal peptide removed form (human)
hTGFBR2/var:Y470D/SigPep-

organism-modification


PR:000062611 TGF-beta receptor type-2 sequence variant E526Q, signal peptide removed form (human)
hTGFBR2/var:E526Q/SigPep-

organism-modification


PR:000062709 TGF-beta receptor type-2 sequence variant R528C, signal peptide removed form (human)
hTGFBR2/var:R528C/SigPep-

organism-modification


PR:000062958 TGF-beta receptor type-2 sequence variant D522N, signal peptide removed form (human)
hTGFBR2/var:D522N/SigPep-

organism-modification


PR:000064130 TGF-beta receptor type-2 sequence variant R528H, signal peptide removed form (human)
hTGFBR2/var:R528H/SigPep-

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hTGFBR2 forms found in complexes   

hTGFBR2 Component
 Complexes
PR:000025962 hTGFBR2/iso:RII-1/SigPep-/Phos:1 PR:000025963 transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000000060 hTGFBR2/var:A355P PMID:15731757
PR:000000061 hTGFBR2/var:V387M PMID:11212236
PR:000000062 hTGFBR2/var:N435S PMID:11212236
PR:000000063 hTGFBR2/var:V447A PMID:11212236
PR:000000065 hTGFBR2/var:L452M PMID:11212236
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:11483955
PR:P37173-2 hTGFBR2/iso:RII-2 PMID:7959019; PMID:8635485
GO:0007181 transforming growth factor beta receptor complex assemblyPR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1310899; PMID:8774881
GO:0008284 positive regulation of cell population proliferationPR:000000058 hTGFBR2/var:T315M PMID:9590282
PR:P37173-2 hTGFBR2/iso:RII-2 PMID:7959019

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0050466 Loeys-Dietz syndromePR:000000050 hTGFBR2/var:L308P PMID:15235604
PR:000000051 hTGFBR2/var:R460H PMID:15731757
PR:000000052 hTGFBR2/var:R460C PMID:15731757
PR:000000054 hTGFBR2/var:R528C PMID:15731757
PR:000000055 hTGFBR2/var:R528H PMID:15731757
PR:000000056 hTGFBR2/var:R537C PMID:15235604
PR:000000057 hTGFBR2/var:G357W PMID:15731757
PR:000000059 hTGFBR2/var:Y336N PMID:15731757
PR:000000060 hTGFBR2/var:A355P PMID:15731757
PR:000000064 hTGFBR2/var:S449F PMID:15235604
DO:3748 esophagus squamous cell carcinomaPR:000000053 hTGFBR2/var:E526Q PMID:10789724
DO:3883 Lynch syndromePR:000000058 hTGFBR2/var:T315M PMID:9590282

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005026 transforming growth factor beta receptor activity, type IIPR:000000061 hTGFBR2/var:V387M PMID:11212236
PR:000000062 hTGFBR2/var:N435S PMID:11212236
PR:000000063 hTGFBR2/var:V447A PMID:11212236
PR:000000065 hTGFBR2/var:L452M PMID:11212236
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:11483955
PR:P37173-2 hTGFBR2/iso:RII-2 PMID:7959019; PMID:8635485
NOT GO:0005026 transforming growth factor beta receptor activity, type IIPR:000000050 hTGFBR2/var:L308P PMID:15235604
PR:000000053 hTGFBR2/var:E526Q PMID:10789724
PR:000000056 hTGFBR2/var:R537C PMID:15235604
PR:000000064 hTGFBR2/var:S449F PMID:15235604
GO:0005515 protein bindingPR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
GO:0050431 transforming growth factor beta bindingPR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:11850637; PMID:1310899
PR:P37173-2 hTGFBR2/iso:RII-2 PMID:8635485

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0016020 membranePR:000000060 hTGFBR2/var:A355P PMID:15731757
PR:000000061 hTGFBR2/var:V387M PMID:11212236
PR:000000063 hTGFBR2/var:V447A PMID:11212236
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1310899