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Protein Ontology report - TGF-beta receptor type-2 (human)
PR:P37173 - http://purl.obolibrary.org/obo/PR_P37173
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P37173   
  PRO nameTGF-beta receptor type-2 (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFBR2
Gene-based: RELATED:TGFBR2
Other: EXACT:TbetaR-II (human) | TGF-beta receptor type II (human) | TGF-beta type II receptor (human) | TGFR-2 (human) | transforming growth factor-beta receptor type II (human)
  Definition"A TGF-beta receptor type-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P37173] 
  PRO Categoryorganism-gene 
  ParentPR:000000005 TGF-beta receptor type-2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11773 TGFBR2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 19                                        
         Modification0                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P37173
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P37173
TGF-beta receptor type-2 (human)
hTGFBR2
"A TGF-beta receptor type-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P37173]

organism-sequence


PR:000000050
TGF-beta receptor type-2 sequence variant L308P (human)
hTGFBR2/var:L308P
"A TGF-beta receptor type-2 (human) that has a Pro residue at the position equivalent to Leu-308 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Leu-308, CHEBI:50342." [PMID:15235604, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000051
TGF-beta receptor type-2 sequence variant R460H (human)
hTGFBR2/var:R460H
"A TGF-beta receptor type-2 (human) that has a His residue at the position equivalent to Arg-460 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-460, CHEBI:29979." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000052
TGF-beta receptor type-2 sequence variant R460C (human)
hTGFBR2/var:R460C
"A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-460 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-460, CHEBI:29950." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000053
TGF-beta receptor type-2 sequence variant E526Q (human)
hTGFBR2/var:E526Q
"A TGF-beta receptor type-2 (human) that has a Gln residue at the position equivalent to Glu-526 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Glu-526, CHEBI:30011." [PMID:10789724, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000054
TGF-beta receptor type-2 sequence variant R528C (human)
hTGFBR2/var:R528C
"A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-528, CHEBI:29950." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000055
TGF-beta receptor type-2 sequence variant R528H (human)
hTGFBR2/var:R528H
"A TGF-beta receptor type-2 (human) that has a His residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-528, CHEBI:29979." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000056
TGF-beta receptor type-2 sequence variant R537C (human)
hTGFBR2/var:R537C
"A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-537 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-537, CHEBI:29950." [PMID:15235604, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000057
TGF-beta receptor type-2 sequence variant G357W (human)
hTGFBR2/var:G357W
"A TGF-beta receptor type-2 (human) that has a Trp residue at the position equivalent to Gly-357 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Gly-357, CHEBI:29954." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000058
TGF-beta receptor type-2 sequence variant T315M (human)
hTGFBR2/var:T315M
"A TGF-beta receptor type-2 (human) that has a Met residue at the position equivalent to Thr-315 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Thr-315, CHEBI:16044." [PMID:9590282, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000059
TGF-beta receptor type-2 sequence variant Y336N (human)
hTGFBR2/var:Y336N
"A TGF-beta receptor type-2 (human) that has an Asn residue at the position equivalent to Tyr-336 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Tyr-336, CHEBI:50347." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000060
TGF-beta receptor type-2 sequence variant A355P (human)
hTGFBR2/var:A355P
"A TGF-beta receptor type-2 (human) that has a Pro residue at the position equivalent to Ala-355 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Ala-355, CHEBI:50342." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000061
TGF-beta receptor type-2 sequence variant V387M (human)
hTGFBR2/var:V387M
"A TGF-beta receptor type-2 (human) that has a Met residue at the position equivalent to Val-387 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Val-387, CHEBI:16044." [PMID:11212236, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000062
TGF-beta receptor type-2 sequence variant N435S (human)
hTGFBR2/var:N435S
"A TGF-beta receptor type-2 (human) that has a Ser residue at the position equivalent to Asn-435 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Asn-435, CHEBI:29999." [PMID:11212236, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000063
TGF-beta receptor type-2 sequence variant V447A (human)
hTGFBR2/var:V447A
"A TGF-beta receptor type-2 (human) that has an Ala residue at the position equivalent to Val-447 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Val-447, CHEBI:46217." [PMID:11212236, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000064
TGF-beta receptor type-2 sequence variant S449F (human)
hTGFBR2/var:S449F
"A TGF-beta receptor type-2 (human) that has a Phe residue at the position equivalent to Ser-449 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Ser-449, CHEBI:29997." [PMID:15235604, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:000000065
TGF-beta receptor type-2 sequence variant L452M (human)
hTGFBR2/var:L452M
"A TGF-beta receptor type-2 (human) that has a Met residue at the position equivalent to Leu-452 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Leu-452, CHEBI:16044." [PMID:11212236, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:P37173-1
TGF-beta receptor type-2 isoform RII-1 (human)
hTGFBR2/iso:RII-1
"A TGF-beta receptor type-2 isoform RII-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P37173]

organism-modification


PR:000036408
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
"A TGF-beta receptor type-2 isoform RII-1, signal peptide removed form in human. UniProtKB:P37173-1, 23-567." [PMID:11483955, PMID:11850637, PMID:1310899, PMID:1850637, PMID:8774881, PRO:CNA]
Yes
organism-modification


PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1
"A TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 in human. UniProtKB:P37173-1, 23-567, Ser-213/Ser-409, MOD:00046|Tyr-259/Tyr-336/Tyr-424, MOD:00048." [PID:TGFB/TGFBR2/TGFBR1]

Yes
organism-sequence


PR:P37173-2
TGF-beta receptor type-2 isoform RII-2 (human)
hTGFBR2/iso:RII-2
"A TGF-beta receptor type-2 isoform RII-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P37173]
Yes
organism-sequence


PR:P37173-3
TGF-beta receptor type-2 isoform h3 (human)
hTGFBR2/iso:h3
"A TGF-beta receptor type-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37173-3." [PRO:DNx, UniProtKB:P37173]

organism-modification


PR:000085798
TGF-beta receptor type-2, signal peptide removed form (human)
hTGFBR2/SigPep-
"A TGF-beta receptor type-2 (human) that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567." [PRO:DNx, Reactome:R-HSA-170842]

organism-modification


PR:000036408
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
"A TGF-beta receptor type-2 isoform RII-1, signal peptide removed form in human. UniProtKB:P37173-1, 23-567." [PMID:11483955, PMID:11850637, PMID:1310899, PMID:1850637, PMID:8774881, PRO:CNA]
Yes
organism-modification


PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1
"A TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 in human. UniProtKB:P37173-1, 23-567, Ser-213/Ser-409, MOD:00046|Tyr-259/Tyr-336/Tyr-424, MOD:00048." [PID:TGFB/TGFBR2/TGFBR1]

Yes
organism-modification


PR:000049434
TGF-beta receptor type-2, signal peptide removed neddylated 1 (human)
hTGFBR2/SigPep-/Nedd:1
"A TGF-beta receptor type-2 (human) that has had the signal peptide removed and has been post-translationally modified to include neddylated lysine at positions 556 and 567 of the amino acid sequence represented by UniProtKB:P37173. UniProtKB:P37173, 23-567, Lys-556/Lys-567, MOD:01150." [PRO:DNx, Reactome:R-HSA-4332222]

organism-modification


PR:000060724
TGF-beta receptor type-2 sequence variant Y470D, signal peptide removed form (human)
hTGFBR2/var:Y470D/SigPep-
"A TGF-beta receptor type-2 (human) that has an Asp residue at the position equivalent to Tyr-470 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Tyr-470, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-3640905]

organism-modification


PR:000062611
TGF-beta receptor type-2 sequence variant E526Q, signal peptide removed form (human)
hTGFBR2/var:E526Q/SigPep-
"A TGF-beta receptor type-2 (human) that has a Gln residue at the position equivalent to Glu-526 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Glu-526, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-3645770]

organism-modification


PR:000062709
TGF-beta receptor type-2 sequence variant R528C, signal peptide removed form (human)
hTGFBR2/var:R528C/SigPep-
"A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Arg-528, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-3640899]

organism-modification


PR:000062958
TGF-beta receptor type-2 sequence variant D522N, signal peptide removed form (human)
hTGFBR2/var:D522N/SigPep-
"A TGF-beta receptor type-2 (human) that has an Asn residue at the position equivalent to Asp-522 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Asp-522, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-3640907]

organism-modification


PR:000064130
TGF-beta receptor type-2 sequence variant R528H, signal peptide removed form (human)
hTGFBR2/var:R528H/SigPep-
"A TGF-beta receptor type-2 (human) that has a His residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Arg-528, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-3640894]

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hTGFBR2 forms found in complexes   

hTGFBR2 Component
 Complexes
PR:000025962 hTGFBR2/iso:RII-1/SigPep-/Phos:1 PR:000025963 transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000000060 hTGFBR2/var:A355P PMID:15731757
PR:000000061 hTGFBR2/var:V387M PMID:11212236
PR:000000062 hTGFBR2/var:N435S PMID:11212236
PR:000000063 hTGFBR2/var:V447A PMID:11212236
PR:000000065 hTGFBR2/var:L452M PMID:11212236
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:11483955
PR:P37173-2 hTGFBR2/iso:RII-2 PMID:7959019; PMID:8635485
GO:0007181 transforming growth factor beta receptor complex assemblyPR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1310899; PMID:8774881
GO:0008284 positive regulation of cell population proliferationPR:000000058 hTGFBR2/var:T315M PMID:9590282
PR:P37173-2 hTGFBR2/iso:RII-2 PMID:7959019

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0050466 Loeys-Dietz syndromePR:000000050 hTGFBR2/var:L308P PMID:15235604
PR:000000051 hTGFBR2/var:R460H PMID:15731757
PR:000000052 hTGFBR2/var:R460C PMID:15731757
PR:000000054 hTGFBR2/var:R528C PMID:15731757
PR:000000055 hTGFBR2/var:R528H PMID:15731757
PR:000000056 hTGFBR2/var:R537C PMID:15235604
PR:000000057 hTGFBR2/var:G357W PMID:15731757
PR:000000059 hTGFBR2/var:Y336N PMID:15731757
PR:000000060 hTGFBR2/var:A355P PMID:15731757
PR:000000064 hTGFBR2/var:S449F PMID:15235604
DO:3748 esophagus squamous cell carcinomaPR:000000053 hTGFBR2/var:E526Q PMID:10789724
DO:3883 Lynch syndromePR:000000058 hTGFBR2/var:T315M PMID:9590282

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005026 transforming growth factor beta receptor activity, type IIPR:000000061 hTGFBR2/var:V387M PMID:11212236
PR:000000062 hTGFBR2/var:N435S PMID:11212236
PR:000000063 hTGFBR2/var:V447A PMID:11212236
PR:000000065 hTGFBR2/var:L452M PMID:11212236
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:11483955
PR:P37173-2 hTGFBR2/iso:RII-2 PMID:7959019; PMID:8635485
NOT GO:0005026 transforming growth factor beta receptor activity, type IIPR:000000050 hTGFBR2/var:L308P PMID:15235604
PR:000000053 hTGFBR2/var:E526Q PMID:10789724
PR:000000056 hTGFBR2/var:R537C PMID:15235604
PR:000000064 hTGFBR2/var:S449F PMID:15235604
GO:0005515 protein bindingPR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1850637
GO:0050431 transforming growth factor beta bindingPR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:11850637; PMID:1310899
PR:P37173-2 hTGFBR2/iso:RII-2 PMID:8635485

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0016020 membranePR:000000060 hTGFBR2/var:A355P PMID:15731757
PR:000000061 hTGFBR2/var:V387M PMID:11212236
PR:000000063 hTGFBR2/var:V447A PMID:11212236
PR:000036408 hTGFBR2/iso:RII-1/SigPep- PMID:1310899