Home
|
Linked Open Data
|
Browse
|
Search
|
Statistics
|
Download
RACE-PRO
PRO tracker
Community
PRO Consortium
Publications
Documentation
Protein Ontology report - TGF-beta receptor type-2 (human)
PR:P37173 -
http://purl.obolibrary.org/obo/PR_P37173
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:P37173
PRO name
TGF-beta receptor type-2 (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFBR2
Gene-based
:
RELATED:
TGFBR2
Other
:
EXACT:
TbetaR-II (human) | TGF-beta receptor type II (human) | TGF-beta type II receptor (human) | TGFR-2 (human) | transforming growth factor-beta receptor type II (human)
Definition
"A TGF-beta receptor type-2 that is encoded in the genome of human." [PRO:CNA,
UniProtKB:P37173
]
PRO Category
organism-gene
Parent
PR:000000005
TGF-beta receptor type-2
PR:000029067
Homo sapiens protein
Gene Template
HGNC:11773
TGFBR2 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
19
Modification
0
Organism-Modification
9
Term Hierarchy
Visualization
DAG:
OLS:
Back to top
Related Cross References
Db identifiers
UniProtKB:P37173
Back to top
Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:P37173
TGF-beta receptor type-2 (human)
hTGFBR2
"A TGF-beta receptor type-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P37173]
organism-sequence
PR:000000050
TGF-beta receptor type-2 sequence variant L308P (human)
hTGFBR2/var:L308P
"A TGF-beta receptor type-2 (human) that has a Pro residue at the position equivalent to Leu-308 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Leu-308, CHEBI:50342." [PMID:15235604, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000051
TGF-beta receptor type-2 sequence variant R460H (human)
hTGFBR2/var:R460H
"A TGF-beta receptor type-2 (human) that has a His residue at the position equivalent to Arg-460 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-460, CHEBI:29979." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000052
TGF-beta receptor type-2 sequence variant R460C (human)
hTGFBR2/var:R460C
"A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-460 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-460, CHEBI:29950." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000053
TGF-beta receptor type-2 sequence variant E526Q (human)
hTGFBR2/var:E526Q
"A TGF-beta receptor type-2 (human) that has a Gln residue at the position equivalent to Glu-526 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Glu-526, CHEBI:30011." [PMID:10789724, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000054
TGF-beta receptor type-2 sequence variant R528C (human)
hTGFBR2/var:R528C
"A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-528, CHEBI:29950." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000055
TGF-beta receptor type-2 sequence variant R528H (human)
hTGFBR2/var:R528H
"A TGF-beta receptor type-2 (human) that has a His residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-528, CHEBI:29979." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000056
TGF-beta receptor type-2 sequence variant R537C (human)
hTGFBR2/var:R537C
"A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-537 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Arg-537, CHEBI:29950." [PMID:15235604, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000057
TGF-beta receptor type-2 sequence variant G357W (human)
hTGFBR2/var:G357W
"A TGF-beta receptor type-2 (human) that has a Trp residue at the position equivalent to Gly-357 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Gly-357, CHEBI:29954." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000058
TGF-beta receptor type-2 sequence variant T315M (human)
hTGFBR2/var:T315M
"A TGF-beta receptor type-2 (human) that has a Met residue at the position equivalent to Thr-315 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Thr-315, CHEBI:16044." [PMID:9590282, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000059
TGF-beta receptor type-2 sequence variant Y336N (human)
hTGFBR2/var:Y336N
"A TGF-beta receptor type-2 (human) that has an Asn residue at the position equivalent to Tyr-336 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Tyr-336, CHEBI:50347." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000060
TGF-beta receptor type-2 sequence variant A355P (human)
hTGFBR2/var:A355P
"A TGF-beta receptor type-2 (human) that has a Pro residue at the position equivalent to Ala-355 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Ala-355, CHEBI:50342." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000061
TGF-beta receptor type-2 sequence variant V387M (human)
hTGFBR2/var:V387M
"A TGF-beta receptor type-2 (human) that has a Met residue at the position equivalent to Val-387 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Val-387, CHEBI:16044." [PMID:11212236, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000062
TGF-beta receptor type-2 sequence variant N435S (human)
hTGFBR2/var:N435S
"A TGF-beta receptor type-2 (human) that has a Ser residue at the position equivalent to Asn-435 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Asn-435, CHEBI:29999." [PMID:11212236, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000063
TGF-beta receptor type-2 sequence variant V447A (human)
hTGFBR2/var:V447A
"A TGF-beta receptor type-2 (human) that has an Ala residue at the position equivalent to Val-447 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Val-447, CHEBI:46217." [PMID:11212236, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000064
TGF-beta receptor type-2 sequence variant S449F (human)
hTGFBR2/var:S449F
"A TGF-beta receptor type-2 (human) that has a Phe residue at the position equivalent to Ser-449 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Ser-449, CHEBI:29997." [PMID:15235604, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000065
TGF-beta receptor type-2 sequence variant L452M (human)
hTGFBR2/var:L452M
"A TGF-beta receptor type-2 (human) that has a Met residue at the position equivalent to Leu-452 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Leu-452, CHEBI:16044." [PMID:11212236, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:P37173-1
TGF-beta receptor type-2 isoform RII-1 (human)
hTGFBR2/iso:RII-1
"A TGF-beta receptor type-2 isoform RII-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P37173]
organism-modification
PR:000036408
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
"A TGF-beta receptor type-2 isoform RII-1, signal peptide removed form in human. UniProtKB:P37173-1, 23-567." [PMID:11483955, PMID:11850637, PMID:1310899, PMID:1850637, PMID:8774881, PRO:CNA]
Yes
organism-modification
PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1
"A TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 in human. UniProtKB:P37173-1, 23-567, Ser-213/Ser-409, MOD:00046|Tyr-259/Tyr-336/Tyr-424, MOD:00048." [PID:TGFB/TGFBR2/TGFBR1]
Yes
organism-sequence
PR:P37173-2
TGF-beta receptor type-2 isoform RII-2 (human)
hTGFBR2/iso:RII-2
"A TGF-beta receptor type-2 isoform RII-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P37173]
Yes
organism-sequence
PR:P37173-3
TGF-beta receptor type-2 isoform h3 (human)
hTGFBR2/iso:h3
"A TGF-beta receptor type-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37173-3." [PRO:DNx, UniProtKB:P37173]
organism-modification
PR:000085798
TGF-beta receptor type-2, signal peptide removed form (human)
hTGFBR2/SigPep-
"A TGF-beta receptor type-2 (human) that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567." [PRO:DNx, Reactome:R-HSA-170842]
organism-modification
PR:000036408
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
"A TGF-beta receptor type-2 isoform RII-1, signal peptide removed form in human. UniProtKB:P37173-1, 23-567." [PMID:11483955, PMID:11850637, PMID:1310899, PMID:1850637, PMID:8774881, PRO:CNA]
Yes
organism-modification
PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1
"A TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 in human. UniProtKB:P37173-1, 23-567, Ser-213/Ser-409, MOD:00046|Tyr-259/Tyr-336/Tyr-424, MOD:00048." [PID:TGFB/TGFBR2/TGFBR1]
Yes
organism-modification
PR:000049434
TGF-beta receptor type-2, signal peptide removed neddylated 1 (human)
hTGFBR2/SigPep-/Nedd:1
"A TGF-beta receptor type-2 (human) that has had the signal peptide removed and has been post-translationally modified to include neddylated lysine at positions 556 and 567 of the amino acid sequence represented by UniProtKB:P37173. UniProtKB:P37173, 23-567, Lys-556/Lys-567, MOD:01150." [PRO:DNx, Reactome:R-HSA-4332222]
organism-modification
PR:000060724
TGF-beta receptor type-2 sequence variant Y470D, signal peptide removed form (human)
hTGFBR2/var:Y470D/SigPep-
"A TGF-beta receptor type-2 (human) that has an Asp residue at the position equivalent to Tyr-470 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Tyr-470, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-3640905]
organism-modification
PR:000062611
TGF-beta receptor type-2 sequence variant E526Q, signal peptide removed form (human)
hTGFBR2/var:E526Q/SigPep-
"A TGF-beta receptor type-2 (human) that has a Gln residue at the position equivalent to Glu-526 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Glu-526, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-3645770]
organism-modification
PR:000062709
TGF-beta receptor type-2 sequence variant R528C, signal peptide removed form (human)
hTGFBR2/var:R528C/SigPep-
"A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Arg-528, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-3640899]
organism-modification
PR:000062958
TGF-beta receptor type-2 sequence variant D522N, signal peptide removed form (human)
hTGFBR2/var:D522N/SigPep-
"A TGF-beta receptor type-2 (human) that has an Asn residue at the position equivalent to Asp-522 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Asp-522, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-3640907]
organism-modification
PR:000064130
TGF-beta receptor type-2 sequence variant R528H, signal peptide removed form (human)
hTGFBR2/var:R528H/SigPep-
"A TGF-beta receptor type-2 (human) that has a His residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Arg-528, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-3640894]
Back to top
hTGFBR2
forms found in complexes
hTGFBR2
Component
Complexes
PR:000025962
hTGFBR2/iso:RII-1/SigPep-/Phos:1
PR:000025963
transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)
Back to top
Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000050
hTGFBR2/var:L308P
Example: UniProtKB:P37173-1, Leu-308, CHEBI:50342
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15235604
enables
NOT
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:15235604
PR:000000051
hTGFBR2/var:R460H
Example: UniProtKB:P37173-1, Arg-460, CHEBI:29979
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000052
hTGFBR2/var:R460C
Example: UniProtKB:P37173-1, Arg-460, CHEBI:29950
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000053
hTGFBR2/var:E526Q
Example: UniProtKB:P37173-1, Glu-526, CHEBI:30011
associated_with_disease_progression
DO:3748
esophagus squamous cell carcinoma
PMID:10789724
enables
NOT
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:10789724
PR:000000054
hTGFBR2/var:R528C
Example: UniProtKB:P37173-1, Arg-528, CHEBI:29950
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000055
hTGFBR2/var:R528H
Example: UniProtKB:P37173-1, Arg-528, CHEBI:29979
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000056
hTGFBR2/var:R537C
Example: UniProtKB:P37173-1, Arg-537, CHEBI:29950
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15235604
enables
NOT
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:15235604
PR:000000057
hTGFBR2/var:G357W
Example: UniProtKB:P37173-1, Gly-357, CHEBI:29954
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000058
hTGFBR2/var:T315M
Example: UniProtKB:P37173-1, Thr-315, CHEBI:16044
acts_upstream_of_or_within
GO:0008284
positive regulation of cell population proliferation
PMID:9590282
associated_with_disease_progression
DO:3883
Lynch syndrome
PMID:9590282
PR:000000059
hTGFBR2/var:Y336N
Example: UniProtKB:P37173-1, Tyr-336, CHEBI:50347
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000060
hTGFBR2/var:A355P
Example: UniProtKB:P37173-1, Ala-355, CHEBI:50342
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:15731757
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
located_in
GO:0016020
membrane
PMID:15731757
PR:000000061
hTGFBR2/var:V387M
Example: UniProtKB:P37173-1, Val-387, CHEBI:16044
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11212236
enables
decreased
GO:0005026
transforming growth factor beta receptor activity, type II
relative to
PR:000000409
TGF-beta receptor type-2 isoform 1 cleaved 1
PMID:11212236
located_in
GO:0016020
membrane
PMID:11212236
PR:000000062
hTGFBR2/var:N435S
Example: UniProtKB:P37173-1, Asn-435, CHEBI:29999
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11212236
enables
decreased
GO:0005026
transforming growth factor beta receptor activity, type II
relative to
PR:000000409
TGF-beta receptor type-2 isoform 1 cleaved 1
PMID:11212236
PR:000000063
hTGFBR2/var:V447A
Example: UniProtKB:P37173-1, Val-447, CHEBI:46217
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11212236
enables
decreased
GO:0005026
transforming growth factor beta receptor activity, type II
relative to
PR:000000409
TGF-beta receptor type-2 isoform 1 cleaved 1
PMID:11212236
located_in
GO:0016020
membrane
PMID:11212236
PR:000000064
hTGFBR2/var:S449F
Example: UniProtKB:P37173-1, Ser-449, CHEBI:29997
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15235604
enables
NOT
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:15235604
PR:000000065
hTGFBR2/var:L452M
Example: UniProtKB:P37173-1, Leu-452, CHEBI:16044
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11212236
enables
decreased
GO:0005026
transforming growth factor beta receptor activity, type II
relative to
PR:000000409
TGF-beta receptor type-2 isoform 1 cleaved 1
PMID:11212236
PR:000036408
hTGFBR2/iso:RII-1/SigPep-
UniProtKB:P37173-1, 23-567
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11483955
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:1310899
;
PMID:8774881
enables
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:11483955
GO:0005515
protein binding
with
PR:000000634
TGFB3/iso:1/Clv:1
PMID:1850637
GO:0005515
protein binding
PMID:1850637
GO:0050431
transforming growth factor beta binding
PMID:11850637
;
PMID:1310899
located_in
GO:0016020
membrane
PMID:1310899
PR:P37173-2
hTGFBR2/iso:RII-2
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:7959019
;
PMID:8635485
GO:0008284
positive regulation of cell population proliferation
PMID:7959019
enables
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:7959019
;
PMID:8635485
GO:0050431
transforming growth factor beta binding
PMID:8635485
