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Protein Ontology report - RAC-alpha serine/threonine-protein kinase (human)
PR:P31749 - http://purl.obolibrary.org/obo/PR_P31749
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P31749   
  PRO nameRAC-alpha serine/threonine-protein kinase (human) 
  Synonyms
PRO-Short-label: EXACT:hAKT1
Gene-based: RELATED:AKT1 | PKB | RAC
Other: EXACT:PKB alpha (human) | protein kinase B (human) | protein kinase B alpha (human) | proto-oncogene c-Akt (human) | RAC-PK-alpha (human)
  Definition"A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human." [PRO:WCB, UniProtKB:P31749
  PRO Categoryorganism-gene 
  ParentPR:000002190 RAC-alpha serine/threonine-protein kinase
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:391 AKT1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P31749
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:P31749

RAC-alpha serine/threonine-protein kinase (human)

hAKT1


"A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human." [PRO:WCB, UniProtKB:P31749]


organism-sequence



PR:000061890

RAC-alpha serine/threonine-protein kinase sequence variant E17K (human)

hAKT1/var:E17K


"A RAC-alpha serine/threonine-protein kinase (human) that has a Lys residue at the position equivalent to Glu-17 of the amino acid sequence represented by UniProtKB:P31749-1. Example: UniProtKB:P31749-1, Glu-17, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-1500573, Reactome:R-HSA-2219526]


organism-sequence



PR:P31749-1

RAC-alpha serine/threonine-protein kinase isoform 1 (human)

hAKT1/iso:1


"A RAC-alpha serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000027473

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)

hAKT1/iso:1/Phos:2


"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046." [PMID:16549426, PRO:PD]

Yes

organism-modification



PR:000028994

RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)

hAKT1/iso:1/Phos:1


"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 in human. UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046." [PMID:8978681, PRO:ALI]

Yes

organism-sequence



PR:P31749-2

RAC-alpha serine/threonine-protein kinase isoform h2 (human)

hAKT1/iso:h2


"A RAC-alpha serine/threonine-protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P31749-2." [PRO:DNx, UniProtKB:P31749]


organism-modification



PR:000046294

RAC-alpha serine/threonine-protein kinase phosphorylated 3 (human)

hAKT1/Phos:3


"A RAC-alpha serine/threonine-protein kinase phosphorylated 3 in human. UniProtKB:P31749, Ser-473, MOD:00046." [PRO:CNA, PRO:DNx, Reactome:R-HSA-377265]


organism-modification



PR:000046295

RAC-alpha serine/threonine-protein kinase phosphorylated 4 (human)

hAKT1/Phos:4


"A RAC-alpha serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-308 of the amino acid sequence represented by UniProtKB:P31749. UniProtKB:P31749, Thr-308, MOD:00047." [PRO:DNx, Reactome:R-HSA-198634]


organism-modification



PR:000046296

RAC-alpha serine/threonine-protein kinase phosphorylated 1 (human)

hAKT1/Phos:1


"A RAC-alpha serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-308, and phosphoserine at position 473 of the amino acid sequence represented by UniProtKB:P31749. UniProtKB:P31749, Thr-308, MOD:00047|Ser-473, MOD:00046." [PRO:DNx, Reactome:R-HSA-198356, Reactome:R-HSA-198357, Reactome:R-HSA-199430]


organism-modification



PR:000046297

RAC-alpha serine/threonine-protein kinase phosphorylated 5 (human)

hAKT1/Phos:5


"A RAC-alpha serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphotyrosine at positions 315 and 326 of the amino acid sequence represented by UniProtKB:P31749. UniProtKB:P31749, Tyr-315/Tyr-326, MOD:00048." [PRO:DNx, Reactome:R-HSA-8848757]


organism-modification



PR:000061529

RAC-alpha serine/threonine-protein kinase sequence variant E17K phosphorylated 1 (human)

hAKT1/var:E17K/Phos:1


"A RAC-alpha serine/threonine-protein kinase (human) that has a Lys residue at the position equivalent to Glu-17 of the amino acid sequence represented by UniProtKB:P31749-1 and that has been phosphorylated on the residue at the position equivalent to Ser-473. Example: UniProtKB:P31749-1, Glu-17, CHEBI:29967|Ser-473, MOD:00046." [PRO:DNx, Reactome:R-HSA-2243944]


organism-modification



PR:000061599

RAC-alpha serine/threonine-protein kinase sequence variant E17K phosphorylated 2 (human)

hAKT1/var:E17K/Phos:2


"A RAC-alpha serine/threonine-protein kinase (human) that has a Lys residue at the position equivalent to Glu-17 of the amino acid sequence represented by UniProtKB:P31749-1 and that has been phosphorylated on the residues at the positions equivalent to Thr-308 and Ser-473. Example: UniProtKB:P31749-1, Glu-17, CHEBI:29967|Thr-308, MOD:00047|Ser-473, MOD:00046." [PRO:DNx, Reactome:R-HSA-2243935, Reactome:R-HSA-2399994]


organism-modification



PR:000065619

RAC-alpha serine/threonine-protein kinase methylated 1 (human)

hAKT1/Me:1


"A RAC-alpha serine/threonine-protein kinase (human) that has been methylated on the residue at the position equivalent to Cys-60 of the amino acid sequence represented by UniProtKB:P31749-1. Example: UniProtKB:P31749-1, Cys-60, MOD:00660." [IEDB_epitope:1052366, PRO:DNx]


organism-modification



PR:000068716

RAC-alpha serine/threonine-protein kinase phosphorylated 2 (human)

hAKT1/Phos:2


"A RAC-alpha serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-371 of the amino acid sequence represented by UniProtKB:P31749-1. Example: UniProtKB:P31749-1, Thr-371, MOD:00047." [IEDB_epitope:2147736, PRO:DNx]


organism-modification



PR:000072278

RAC-alpha serine/threonine-protein kinase deaminated 1 (human)

hAKT1/Deam:1


"A RAC-alpha serine/threonine-protein kinase (human) that has been deaminated on the residue at the position equivalent to Gln-59 of the amino acid sequence represented by UniProtKB:P31749-1. Example: UniProtKB:P31749-1, Gln-59, MOD:00685." [IEDB_epitope:931423, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027473 hAKT1/iso:1/Phos:2
UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046
acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:16549426
PR:000028994 hAKT1/iso:1/Phos:1
UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046
acts_upstream_of_or_withinGO:0032869 cellular response to insulin stimulus PMID:8978681
GO:0051092 positive regulation of NF-kappaB transcription factor activity PMID:12138205
enablesGO:0004672 protein kinase activity PMID:8978681
GO:0004674 protein serine/threonine kinase activity PMID:12138205
GO:0005515 protein binding PMID:12138205
GO:0005515 protein binding PMID:12138205