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Protein Ontology report - phosphatidylinositol 3-kinase regulatory subunit alpha (human)
PR:P27986 - http://purl.obolibrary.org/obo/PR_P27986
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P27986   
  PRO namephosphatidylinositol 3-kinase regulatory subunit alpha (human) 
  Synonyms
PRO-Short-label: EXACT:hPIK3R1
Gene-based: RELATED:GRB1 | PIK3R1
Other: EXACT:phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha (human) | PI3-kinase regulatory subunit alpha (human) | PI3-kinase subunit p85-alpha (human) | PI3K regulatory subunit alpha (human) | PtdIns-3-kinase regulatory subunit alpha (human) | PtdIns-3-kinase regulatory subunit p85-alpha (human)
  Definition"A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human." [PRO:DNx] 
  PRO Categoryorganism-gene 
  ParentPR:000012724 phosphatidylinositol 3-kinase regulatory subunit alpha
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:8979 PIK3R1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 13                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P27986
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:P27986

phosphatidylinositol 3-kinase regulatory subunit alpha (human)

hPIK3R1


"A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:000060710

phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant K379E (human)

hPIK3R1/var:K379E


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has a Glu residue at the position equivalent to Lys-379 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Lys-379, CHEBI:29972." [PRO:DNx, Reactome:R-HSA-8944148]


organism-sequence



PR:000061166

phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant R574I (human)

hPIK3R1/var:R574I


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has an Ile residue at the position equivalent to Arg-574 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Arg-574, CHEBI:30009." [PRO:DNx, Reactome:R-HSA-2399536]


organism-sequence



PR:000061750

phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant G376R (human)

hPIK3R1/var:G376R


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has an Arg residue at the position equivalent to Gly-376 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Gly-376, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-2399717]


organism-sequence



PR:000062211

phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant D560Y (human)

hPIK3R1/var:D560Y


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has a Tyr residue at the position equivalent to Asp-560 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Asp-560, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-2399421]


organism-sequence



PR:000062219

phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant R574T (human)

hPIK3R1/var:R574T


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has a Thr residue at the position equivalent to Arg-574 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Arg-574, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-2399540]


organism-sequence



PR:000063145

phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant D560H (human)

hPIK3R1/var:D560H


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has a His residue at the position equivalent to Asp-560 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Asp-560, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-2399432]


organism-sequence



PR:000064239

phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant N564D (human)

hPIK3R1/var:N564D


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has an Asp residue at the position equivalent to Asn-564 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Asn-564, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-2399427]


organism-sequence



PR:000064611

phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant N564K (human)

hPIK3R1/var:N564K


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has a Lys residue at the position equivalent to Asn-564 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Asn-564, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-2399431]


organism-sequence



PR:P27986-1

phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 (human)

hPIK3R1/iso:1


"A phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P27986-2

phosphatidylinositol 3-kinase regulatory subunit alpha isoform h2 (human)

hPIK3R1/iso:h2


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-2." [PRO:DNx, UniProtKB:P27986]


organism-sequence



PR:P27986-3

phosphatidylinositol 3-kinase regulatory subunit alpha isoform h3 (human)

hPIK3R1/iso:h3


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-3." [PRO:DNx, UniProtKB:P27986]


organism-sequence



PR:P27986-4

phosphatidylinositol 3-kinase regulatory subunit alpha isoform h4 (human)

hPIK3R1/iso:h4


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-4." [PRO:DNx, UniProtKB:P27986]


organism-sequence



PR:P27986-5

phosphatidylinositol 3-kinase regulatory subunit alpha isoform h5 (human)

hPIK3R1/iso:h5


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-5." [PRO:DNx, UniProtKB:P27986]


organism-modification



PR:000045733

phosphatidylinositol 3-kinase regulatory subunit alpha phosphorylated 1 (human)

hPIK3R1/Phos:1


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has been phosphorylated on the residue at the position equivalent to Tyr-688 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Tyr-688, MOD:00048." [iPTMnet:P27986, PMID:11337495]


organism-modification



PR:000048770

phosphatidylinositol 3-kinase regulatory subunit alpha ubiquitinated form (human)

hPIK3R1/UbiqLys+


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that includes at least one ubiquitinated lysine. UniProtKB:P27986, MOD:01148." [PRO:DNx, Reactome:R-HSA-3080572]


organism-modification



PR:000063059

phosphatidylinositol 3-kinase regulatory subunit alpha phosphotyrosine form (human)

hPIK3R1/PhosTyr+


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that includes at least one phosphorylated tyrosine. UniProtKB:P27986, MOD:00048." [PRO:DNx, Reactome:R-HSA-9680647]


organism-modification



PR:000066843

phosphatidylinositol 3-kinase regulatory subunit alpha deaminated 1 (human)

hPIK3R1/Deam:1


"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has been deaminated on the residue at the position equivalent to Gln-415 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Gln-415, MOD:00685." [IEDB_epitope:2138801, PRO:DNx]


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hPIK3R1 forms found in complexes   

hPIK3R1 Component
Complexes
PR:P27986 hPIK3R1 PR:000028429 GPIb-IX-V:vWF:14-3-3-zeta:p85 (human)