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Protein Ontology report - bone morphogenetic protein 4 (human)
PR:P12644 - http://purl.obolibrary.org/obo/PR_P12644
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P12644   
  PRO namebone morphogenetic protein 4 (human) 
  Synonyms
PRO-Short-label: EXACT:hBMP4
Gene-based: RELATED:BMP2B | BMP4 | DVR4
Other: EXACT:BMP-2B (human) | BMP-4 (human) | bone morphogenetic protein 2B (human)
  Definition"A bone morphogenetic protein 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P12644] 
  PRO Categoryorganism-gene 
  ParentPR:000000165 bone morphogenetic protein 4
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:1071 BMP4 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P12644
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P12644
bone morphogenetic protein 4 (human)
hBMP4
"A bone morphogenetic protein 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P12644]

organism-sequence


PR:P12644-1
bone morphogenetic protein 4 isoform 1 (human)
hBMP4/iso:1
"A bone morphogenetic protein 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-modification


PR:000046492
bone morphogenetic protein 4, signal peptide removed form (human)
hBMP4/SigPep-
"A bone morphogenetic protein 4 (human) that has had the signal peptide removed. UniProtKB:P12644, 20-408." [PRO:DNx, Reactome:R-HSA-2396280]

organism-modification


PR:000072771
bone morphogenetic protein 4, mature form (human)
hBMP4/mature
"A bone morphogenetic protein 4 (human) that has had the signal peptide and propeptide removed. UniProtKB:P12644, 293-408." [PRO:DNx, Reactome:R-HSA-8858573, Reactome:R-HSA-8956775]

organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-modification


PR:000072824
bone morphogenetic protein 4, mature phosphorylated form (human)
hBMP4/mature/PhosRes+
"A bone morphogenetic protein 4 (human) that has had the signal peptide and propeptide removed, and that includes at least one phosphorylated residue. UniProtKB:P12644, 293-408, MOD:00696." [PRO:DNx, Reactome:R-HSA-8956944]

organism-modification


PR:000072771
bone morphogenetic protein 4, mature form (human)
hBMP4/mature
"A bone morphogenetic protein 4 (human) that has had the signal peptide and propeptide removed. UniProtKB:P12644, 293-408." [PRO:DNx, Reactome:R-HSA-8858573, Reactome:R-HSA-8956775]

organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-modification


PR:000072824
bone morphogenetic protein 4, mature phosphorylated form (human)
hBMP4/mature/PhosRes+
"A bone morphogenetic protein 4 (human) that has had the signal peptide and propeptide removed, and that includes at least one phosphorylated residue. UniProtKB:P12644, 293-408, MOD:00696." [PRO:DNx, Reactome:R-HSA-8956944]

organism-modification


PR:000072824
bone morphogenetic protein 4, mature phosphorylated form (human)
hBMP4/mature/PhosRes+
"A bone morphogenetic protein 4 (human) that has had the signal peptide and propeptide removed, and that includes at least one phosphorylated residue. UniProtKB:P12644, 293-408, MOD:00696." [PRO:DNx, Reactome:R-HSA-8956944]

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001649 osteoblast differentiationPR:000036511 hBMP4/iso:1/mature PMID:14749725
GO:0001657 ureteric bud developmentPR:000036511 hBMP4/iso:1/mature PMID:12141440
GO:0001934 positive regulation of protein phosphorylationPR:000036511 hBMP4/iso:1/mature PMID:14749725
GO:0007498 mesoderm developmentPR:000036511 hBMP4/iso:1/mature PMID:9804553
PR:P12644-1 hBMP4/iso:1 PMID:9804553
GO:0030509 BMP signaling pathwayPR:000036511 hBMP4/iso:1/mature PMID:12805376

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005102 signaling receptor bindingPR:000036511 hBMP4/iso:1/mature PMID:11401399; PMID:14660436
GO:0042803 protein homodimerization activityPR:000036511 hBMP4/iso:1/mature PMID:12805376

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036511 hBMP4/iso:1/mature PMID:12805376
GO:0005622 intracellular anatomical structurePR:P12644-1 hBMP4/iso:1 PMID:12805376