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Protein Ontology report - DNA topoisomerase 1 (human)
PR:P11387 - http://purl.obolibrary.org/obo/PR_P11387
 
  Protein Forms      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P11387   
  PRO nameDNA topoisomerase 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hTOP1
Gene-based: RELATED:TOP1
Other: EXACT:DNA topoisomerase I (human)
  Definition"A type 1B DNA topoisomerase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11387
  PRO Categoryorganism-gene 
  ParentPR:000016542 type 1B DNA topoisomerase 1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:11986 TOP1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification0                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P11387
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:P11387

DNA topoisomerase 1 (human)

hTOP1


"A type 1B DNA topoisomerase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11387]


organism-modification



PR:000049508

DNA topoisomerase 1, initiator methionine removed form (human)

hTOP1/InitMet-


"A DNA topoisomerase 1 (human) that has had the initiator methionine removed. UniProtKB:P11387, 2-765." [PRO:DNx, Reactome:R-HSA-4641363]


organism-modification



PR:000049509

DNA topoisomerase 1, initiator methionine removed sumoylated 1 (human)

hTOP1/InitMet-/Sumo:1


"A DNA topoisomerase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include sumoylated lysine at position 117 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, 2-765, Lys-117, MOD:01149." [PRO:DNx, Reactome:R-HSA-4641364]


organism-modification



PR:000066763

DNA topoisomerase 1 deaminated 1 (human)

hTOP1/Deam:1


"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-601 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Gln-601, MOD:00685." [IEDB_epitope:1313507, PRO:DNx]


organism-modification



PR:000069264

DNA topoisomerase 1 deaminated 2 (human)

hTOP1/Deam:2


"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-611 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Asn-611, MOD:00684." [IEDB_epitope:1332910, PRO:DNx]


organism-modification



PR:000069839

DNA topoisomerase 1 deaminated 3 (human)

hTOP1/Deam:3


"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-620 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Asn-620, MOD:00684." [IEDB_epitope:1357057, PRO:DNx]


organism-modification



PR:000071666

DNA topoisomerase 1 deaminated 4 (human)

hTOP1/Deam:4


"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-296 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Asn-296, MOD:00684." [IEDB_epitope:1312361, PRO:DNx]


organism-modification



PR:000073654

DNA topoisomerase 1 deaminated 5 (human)

hTOP1/Deam:5


"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-600 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Gln-600, MOD:00685." [IEDB_epitope:1312137, IEDB_epitope:1313851, PRO:DNx]


organism-modification



PR:000076794

DNA topoisomerase 1 deaminated 6 (human)

hTOP1/Deam:6


"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-599 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Gln-599, MOD:00685." [IEDB_epitope:1312136, IEDB_epitope:1313506, PRO:DNx]


organism-modification



PR:000079112

DNA topoisomerase 1 phosphorylated 1 (human)

hTOP1/Phos:1


"A DNA topoisomerase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-667 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Ser-667, MOD:00046." [IEDB_epitope:2148795, PRO:DNx]


organism-modification



PR:000081429

DNA topoisomerase 1 hydroxylated 1 (human)

hTOP1/Hy:1


"A DNA topoisomerase 1 (human) that has been hydroxylated on the residue at the position equivalent to Lys-248 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Lys-248, MOD:00681." [IEDB_epitope:1328915, PRO:DNx]


organism-modification



PR:000084472

DNA topoisomerase 1 deaminated 7 (human)

hTOP1/Deam:7


"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-539 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Asn-539, MOD:00684." [IEDB_epitope:1575969, PRO:DNx]