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Protein Ontology report - replicase polyprotein 1ab (SARS-CoV-2)
PR:P0DTD1-1 - http://purl.obolibrary.org/obo/PR_P0DTD1-1
 
  Protein Forms      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P0DTD1-1   
  PRO namereplicase polyprotein 1ab (SARS-CoV-2) 
  Synonyms
PRO-Short-label: EXACT:rep/iso:ORF1ab (SARS2)
PRO-proteoform-ftid: EXACT:PRO_0000449618
Other: EXACT:ORF1ab polyprotein (SARS-CoV-2) | pp1ab (SARS-CoV-2)
  Definition"A rep gene translation product (SARS-CoV-2) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P0DTD1-1. Requires ribosomal frameshifting." [GenPept:YP_009724389, PRO:DAN, UniProtKB:P0DTD1] 
  CommentNote: 7096 aa protein. Undergoes additional processing by proteolytic cleavage. 
  PRO Categoryorganism-sequence 
  ParentPR:000050263 rep gene translation product (SARS-CoV-2)
  TaxonNCBITaxon:2697049 Severe acute respiratory syndrome coronavirus 2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P0DTD1-1
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-sequence


PR:P0DTD1-1
replicase polyprotein 1ab (SARS-CoV-2)
rep/iso:ORF1ab (SARS2)
"A rep gene translation product (SARS-CoV-2) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P0DTD1-1. Requires ribosomal frameshifting." [GenPept:YP_009724389, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050283
ORF1ab proteolytic cleavage product (SARS-CoV-2)
ORF1ab/ClvPrd (SARS2)
"A replicase polyprotein 1ab (SARS-CoV-2) that has been processed by proteolytic cleavage." [PRO:DAN]

organism-modification


PR:000050284
RNA-directed RNA polymerase nsp12 (SARS-CoV-2)
ORF1ab/Clv:nsp12 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 4392-4393 and 5324-5325. UniProtKB:P0DTD1, 4393-5324." [GenPept:YP_009725307, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050285
helicase nsp13 (SARS-CoV-2)
ORF1ab/Clv:nsp13 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 5324-5325 and 5925-5926. UniProtKB:P0DTD1, 4393-5324." [GenPept:YP_009725308, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050286
proofreading exoribonuclease nsp14 (SARS-CoV-2)
ORF1ab/Clv:nsp14 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 5925-5926 and 6452-6453. UniProtKB:P0DTD1, 4393-5324." [GenPept:YP_009725309, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050287
uridylate-specific endoribonuclease nsp15 (SARS-CoV-2)
ORF1ab/Clv:nsp15 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 6452-6453 and 6798-6799. UniProtKB:P0DTD1, 6453-6798." [GenPept:YP_009725310, PRO:DAN, UniProtKB:P0DTD1]

organism-modification


PR:000050288
2'-O-methyltransferase nsp16 (SARS-CoV-2)
ORF1ab/Clv:nsp16 (SARS2)
"An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the C-terminal portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 6798-6799. UniProtKB:P0DTD1, 6453-6798." [GenPept:YP_009725311, PRO:DAN, UniProtKB:P0DTD1]