back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - DNA polymerase beta (human)
PR:P06746 - http://purl.obolibrary.org/obo/PR_P06746
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:P06746   
  PRO nameDNA polymerase beta (human) 
  Synonyms
PRO-Short-label: EXACT:hPOLB
Gene-based: RELATED:POLB
Other: EXACT:5'-deoxyribose-phosphate lyase (human) | 5'-dRP lyase (human) | AP lyase (human)
  Definition"A DNA polymerase beta that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-gene 
  ParentPR:000012962 DNA polymerase beta
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:9174 POLB (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
UniProtKB:P06746
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P06746
DNA polymerase beta (human)
hPOLB
"A DNA polymerase beta that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:P06746-1
DNA polymerase beta isoform 1 (human)
hPOLB/iso:1
"A DNA polymerase beta isoform 1 that is encoded in the genome of human." [PRO:PD]

organism-modification


PR:000028604
DNA polymerase beta acetylated 1 (human)
hPOLB/Ac:1
"A DNA polymerase beta acetylated 1 in human. UniProtKB:P06746, Lys-72, MOD:00064." [KAT:P06746, PMID:12453427, PRO:PD]
Yes
organism-modification


PR:000045373
DNA polymerase beta unacetylated 1 (human)
hPOLB/UnAc:1
"A DNA polymerase beta (human) that lacks acetylation on the residue equivalent to Lys-72 of the amino acid sequence represented by UniProtKB:P06746. UniProtKB:P06746, Lys-72, PR:000026291." [PMID:12453427, PRO:CNA]
Yes
organism-modification


PR:000048840
DNA polymerase beta, initiator methionine removed ubiquitinated form (human)
hPOLB/InitMet-/UbiqLys+
"A DNA polymerase beta (human) that has had the initiator methionine removed and that includes at least one ubiquitinated lysine. UniProtKB:P06746, 2-335, MOD:01148." [PRO:DNx, Reactome:R-HSA-6783152]

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000028604 hPOLB/Ac:1
UniProtKB:P06746, Lys-72, MOD:00064		 enablesdecreased GO:0016829 lyase activity relative to PR:000045373 DNA polymerase beta unmodified form (human) PMID:12453427
PR:000045373 hPOLB/UnAc:1
UniProtKB:P06746, Lys-72, PR:000026291		 acts_upstream_of_or_withinGO:0006284 base-excision repair PMID:12453427
enablesGO:0016829 lyase activity PMID:12453427