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Protein Ontology report - protein kinase C beta type (human)
PR:P05771 - http://purl.obolibrary.org/obo/PR_P05771
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P05771   
  PRO nameprotein kinase C beta type (human) 
  Synonyms
PRO-Short-label: EXACT:hPRKCB
Gene-based: RELATED:PKCB | PRKCB | PRKCB1
Other: EXACT:PKC-B (human) | PKC-beta (human)
  Definition"A protein kinase C beta type that is encoded in the genome of human." [PRO:CNA, UniProtKB:P05771
  PRO Categoryorganism-gene 
  ParentPR:000003059 protein kinase C beta type
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:9395 PRKCB (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P05771
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-gene



PR:P05771

protein kinase C beta type (human)

hPRKCB


"A protein kinase C beta type that is encoded in the genome of human." [PRO:CNA, UniProtKB:P05771]


organism-sequence



PR:P05771-1

protein kinase C beta type isoform Beta-I (human)

hPRKCB/iso:Beta-I


"A protein kinase C beta type isoform 1 that is encoded in the genome of human." [PRO:DNx]

Yes

organism-sequence



PR:P05771-2

protein kinase C beta type isoform Beta-II (human)

hPRKCB/iso:Beta-II


"A protein kinase C beta type isoform 2 that is encoded in the genome of human." [PRO:DNx]

Yes

organism-modification



PR:000049853

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049854

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and lacks a phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000049855

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049856

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500,a phosphothreonine at position 641 and a phosphoserine at position 660. UniProtKB:P05771-2, 2-673, Thr-500/Thr-641/Ser-660, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000048913

protein kinase C beta type, initiator methionine removed form (human)

hPRKCB/InitMet-


"A protein kinase C beta type (human) that has had the initiator methionine removed. UniProtKB:P05771, 2-671." [PRO:DNx, Reactome:R-HSA-156467, Reactome:R-HSA-58198]


organism-modification



PR:000048914

protein kinase C beta type, initiator methionine removed phosphorylated 1 (human)

hPRKCB/InitMet-/Phos:1


"A protein kinase C beta type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the amino acid sequence represented by UniProtKB:P05771. UniProtKB:P05771, 2-671, Thr-500, MOD:00047." [PRO:DNx, Reactome:R-HSA-5218728]


organism-modification



PR:000048915

protein kinase C beta type, initiator methionine removed phosphorylated 2 (human)

hPRKCB/InitMet-/Phos:2


"A protein kinase C beta type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 500 and 642, and phosphoserine at position 661 of the amino acid sequence represented by UniProtKB:P05771. UniProtKB:P05771, 2-671, Thr-500/Thr-642, MOD:00047|Ser-661, MOD:00046." [PRO:DNx, Reactome:R-HSA-5218706, Reactome:R-HSA-5223294]


organism-modification



PR:000049853

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049854

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 1 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:1


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and lacks a phosphothreonine at position 500. UniProtKB:P05771-2, 2-673, Thr-500, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000049855

protein kinase C beta type isoform Beta-II, initiator methionine removed phosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/Phos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500 of the activation loop, and phosphothreonine at position 641 and phosphoserine at position 660 of the Pkinase_C domain (Pfam:PF00433). UniProtKB:P05771-2, 2-673, Thr-500/Thr-641, MOD:00047|Ser-660, MOD:00046." [PMID:8749392, PRO:KER]

Yes

organism-modification



PR:000049856

protein kinase C beta type isoform Beta-II, initiator methionine removed unphosphorylated 2 (human)

hPRKCB/iso:Beta-II/InitMet-/UnPhos:2


"A protein kinase C beta type isoform Beta-II (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 500,a phosphothreonine at position 641 and a phosphoserine at position 660. UniProtKB:P05771-2, 2-673, Thr-500/Thr-641/Ser-660, PR:000026291." [PMID:8749392, PRO:KER]


organism-modification



PR:000049887

protein kinase C beta type phosphorylated 1 (human)

hPRKCB/Phos:1


"A protein kinase C beta type phosphorylated 1 in human. UniProtKB:P05771, Thr-500, MOD:00047." [PMID:8749392, PRO:KER]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0001666 response to hypoxiaPR:P05771-2 hPRKCB/iso:Beta-II MGI_ref:3847400; PMID:18323529
NOT GO:0001666 response to hypoxiaPR:P05771-1 hPRKCB/iso:Beta-I MGI_ref:3847400; PMID:18323529
increased GO:0006468 protein phosphorylationPR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2 PMID:8749392

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0001786 phosphatidylserine bindingPR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2 PMID:9218480
GO:0004674 protein serine/threonine kinase activityPR:000049853 hPRKCB/iso:Beta-II/InitMet-/Phos:1 PMID:8749392
GO:0005509 calcium ion bindingPR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2 PMID:9218480

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005737 cytoplasmPR:000049853 hPRKCB/iso:Beta-II/InitMet-/Phos:1 PMID:9756933
increased GO:0005737 cytoplasmPR:000049855 hPRKCB/iso:Beta-II/InitMet-/Phos:2 PMID:9756933
GO:0005886 plasma membranePR:000049853 hPRKCB/iso:Beta-II/InitMet-/Phos:1 PMID:9756933
GO:0016020 membranePR:P05771-1 hPRKCB/iso:Beta-I MGI_ref:3847400; PMID:18323529
PR:P05771-2 hPRKCB/iso:Beta-II MGI_ref:3847400; PMID:18323529