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Protein Ontology report - Rho-associated protein kinase 2 (human)
PR:O75116 - http://purl.obolibrary.org/obo/PR_O75116
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:O75116   
  PRO nameRho-associated protein kinase 2 (human) 
  Synonyms
PRO-Short-label: EXACT:hROCK2
Gene-based: RELATED:KIAA0619 | ROCK2
Other: EXACT:p164 ROCK-2 (human) | Rho kinase 2 (human) | Rho-associated, coiled-coil-containing protein kinase 2 (human) | Rho-associated, coiled-coil-containing protein kinase II (human) | ROCK-II (human)
  Definition"A Rho-associated protein kinase 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O75116] 
  PRO Categoryorganism-gene 
  ParentPR:000000121 Rho-associated protein kinase 2
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:10252 ROCK2 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O75116
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:O75116 Rho-associated protein kinase 2 (human)
hROCK2

organism-sequence


PR:O75116-1 Rho-associated protein kinase 2 isoform 1 (human)
hROCK2/iso:1
Yes
organism-modification


PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)
hROCK2/iso:1/Clv:1
Yes
organism-modification


PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)
hROCK2/iso:1/Phos:1
Yes
organism-modification


PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)
hROCK2/iso:1/Phos:2
Yes
organism-modification


PR:000066276 Rho-associated protein kinase 2 methylated 1 (human)
hROCK2/Me:1

organism-modification


PR:000071951 Rho-associated protein kinase 2 methylated 2 (human)
hROCK2/Me:2

organism-modification


PR:000074887 Rho-associated protein kinase 2 phosphorylated 1 (human)
hROCK2/Phos:1

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006468 protein phosphorylationPR:000036477 hROCK2/iso:1/Clv:1 PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1 PMID:17446864
PR:O75116-1 hROCK2/iso:1 PMID:9933571
GO:0030036 actin cytoskeleton organizationPR:000036477 hROCK2/iso:1/Clv:1 PMID:15699075
GO:0042770 signal transduction in response to DNA damagePR:000036479 hROCK2/iso:1/Phos:2 PMID:17525332
GO:0051260 protein homooligomerizationPR:O75116-1 hROCK2/iso:1 PMID:15291762

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004674 protein serine/threonine kinase activityPR:000036477 hROCK2/iso:1/Clv:1 PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1 PMID:17446864
PR:O75116-1 hROCK2/iso:1 PMID:9933571
GO:0031267 small GTPase bindingPR:O75116-1 hROCK2/iso:1 PMID:11350930

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005622 intracellular anatomical structurePR:000036477 hROCK2/iso:1/Clv:1 PMID:15699075
PR:O75116-1 hROCK2/iso:1 PMID:16574662
GO:0005634 nucleusPR:000036478 hROCK2/iso:1/Phos:1 PMID:15302935