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Protein Ontology report - neuropilin-1 (human)
PR:O14786 - http://purl.obolibrary.org/obo/PR_O14786
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:O14786   
  PRO nameneuropilin-1 (human) 
  Synonyms
PRO-Short-label: EXACT:hNRP1
Gene-based: RELATED:NRP | NRP1 | VEGF165R
Other: EXACT:CD304 (human) | vascular endothelial cell growth factor 165 receptor (human)
  Definition"A neuropilin-1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O14786] 
  PRO Categoryorganism-gene 
  ParentPR:000001900 neuropilin-1
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:8004 NRP1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:O14786
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:O14786
neuropilin-1 (human)
hNRP1
"A neuropilin-1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O14786]

organism-sequence


PR:O14786-1
neuropilin-1 isoform 1 (human)
hNRP1/iso:1
"A neuropilin-1 isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-modification


PR:000036635
neuropilin-1 isoform 1, signal peptide removed form (human)
hNRP1/iso:1/SigPep-
"A neuropilin-1 isoform 1, signal peptide removed form in human. UniProtKB:O14786-1, 22-923." [PMID:11986311, PMID:16763549, PRO:JAN]
Yes
organism-modification


PR:000036631
neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)
hNRP1/iso:1/ClvOGlyco:1
"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215." [PMID:16763549, PRO:JAN]
Yes
organism-modification


PR:000036632
neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)
hNRP1/iso:1/ClvOGlyco:2
"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213." [PMID:16763549, PRO:JAN]
Yes
organism-sequence


PR:O14786-2
neuropilin-1 isoform 2 (human)
hNRP1/iso:2
"A neuropilin-1 isoform 2 that is encoded in the genome of human." [PRO:CNA]

organism-sequence


PR:O14786-3
neuropilin-1 isoform h3 (human)
hNRP1/iso:h3
"A neuropilin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14786-3." [PRO:DNx, UniProtKB:O14786]

organism-modification


PR:000050705
neuropilin-1 N-glycosylated 1 (human)
hNRP1/NGlyco:1
"A neuropilin-1 (human) that has been N-glycosylated at the residue equivalent to Asn-150 of the amino acid sequence represented by UniProtKB:O14786-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:O14786-1, Asn-150, MOD:00160~GNO:G59626AS." [GlyGen:O14786-1, PMID:29671580, PRO:DNx]

organism-modification


PR:000050706
neuropilin-1 O-glycosylated 1 (human)
hNRP1/OGlyco:1
"A neuropilin-1 (human) that has been O-glycosylated at the residue equivalent to Ser-637 of the amino acid sequence represented by UniProtKB:O14786-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:O14786-1, Ser-637, MOD:00002~GNO:G53434XO." [GlyGen:O14786-1, PMID:30459171, PRO:DNx]

organism-modification


PR:000050707
neuropilin-1 O-glycosylated 2 (human)
hNRP1/OGlyco:2
"A neuropilin-1 (human) that has been O-glycosylated at the residue equivalent to Thr-589 of the amino acid sequence represented by UniProtKB:O14786-1, in which the glycan composition is represented by GlyTouCan:G57317CE. Example: UniProtKB:O14786-1, Thr-589, MOD:00005~GNO:G57317CE." [GlyGen:O14786-1, PMID:30459171, PRO:DNx]

organism-modification


PR:000050708
neuropilin-1 O-glycosylated 3 (human)
hNRP1/OGlyco:3
"A neuropilin-1 (human) that has been O-glycosylated at the residue equivalent to Thr-638 of the amino acid sequence represented by UniProtKB:O14786-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O14786-1, Thr-638, MOD:00005~GNO:G43417UB." [GlyGen:O14786-1, PMID:30459171, PRO:DNx]

organism-modification


PR:000050709
neuropilin-1 O-glycosylated 4 (human)
hNRP1/OGlyco:4
"A neuropilin-1 (human) that has been O-glycosylated at the residue equivalent to Thr-830 of the amino acid sequence represented by UniProtKB:O14786-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O14786-1, Thr-830, MOD:00005~GNO:G43417UB." [GlyGen:O14786-1, PMID:30459171, PRO:DNx]

organism-modification


PR:000085953
neuropilin-1, signal peptide removed form (human)
hNRP1/SigPep-
"A neuropilin-1 (human) that has had the signal peptide removed. Example: UniProtKB:O14786-1, 22-923." [PRO:DNx, Reactome:R-HSA-3008773]

organism-modification


PR:000036635
neuropilin-1 isoform 1, signal peptide removed form (human)
hNRP1/iso:1/SigPep-
"A neuropilin-1 isoform 1, signal peptide removed form in human. UniProtKB:O14786-1, 22-923." [PMID:11986311, PMID:16763549, PRO:JAN]
Yes
organism-modification


PR:000036631
neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 (human)
hNRP1/iso:1/ClvOGlyco:1
"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 1 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215." [PMID:16763549, PRO:JAN]
Yes
organism-modification


PR:000036632
neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 (human)
hNRP1/iso:1/ClvOGlyco:2
"A neuropilin-1 isoform 1, signal peptide removed O-glycosylated 2 in human. UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213." [PMID:16763549, PRO:JAN]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036631 hNRP1/iso:1/ClvOGlyco:1
UniProtKB:O14786-1, 22-923, Ser-612, MOD:00215		 acts_upstream_of_or_withinGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway PMID:16763549
enablesincreased GO:0005515 protein binding with PR:P15692-4 PMID:16763549
GO:0043184 vascular endothelial growth factor receptor 2 binding PMID:16763549
PR:000036632 hNRP1/iso:1/ClvOGlyco:2
UniProtKB:O14786-1, 22-923, Ser-612, MOD:00213		 acts_upstream_of_or_withinGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway PMID:16763549
enablesincreased GO:0005515 protein binding with PR:P15692-4 PMID:16763549
decreased GO:0043184 vascular endothelial growth factor receptor 2 binding relative to PR:000036635 hNRP1/iso:1/SigPep- PMID:16763549
PR:000036635 hNRP1/iso:1/SigPep-
UniProtKB:O14786-1, 22-923		 enablesGO:0005515 protein binding with PR:P15692-4 PMID:11986311
GO:0005515 protein binding with PR:P15692-4 PMID:11986311
GO:0005515 protein binding with PR:P49763-3 PMID:11986311
GO:0008201 heparin binding PMID:11986311
GO:0043184 vascular endothelial growth factor receptor 2 binding PMID:16763549