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Protein Ontology report - TGF-beta receptor type-2, signal peptide removed form (human)
PR:000085798 -
http://purl.obolibrary.org/obo/PR_000085798
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
GPI
PRO ID
PR:000085798
PRO name
TGF-beta receptor type-2, signal peptide removed form (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFBR2/SigPep-
PRO-proteoform-std
:
EXACT:
UniProtKB:P37173
, 23-567
NARROW:
UniProtKB:P37173-1
, 23-567
Reactome-displayName
:
RELATED:
TGFBR2
Definition
"A TGF-beta receptor type-2 (human) that has had the signal peptide removed. Example:
UniProtKB:P37173-1
, 23-567." [PRO:DNx,
Reactome:R-HSA-170842
]
PRO Category
organism-modification
Parent
PR:000018266
TGF-beta receptor type-2, signal peptide removed form
PR:P37173
TGF-beta receptor type-2 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
0
Organism-Modification
9
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
organism-modification
PR:000085798
TGF-beta receptor type-2, signal peptide removed form (human)
hTGFBR2/SigPep-
"A TGF-beta receptor type-2 (human) that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567." [PRO:DNx, Reactome:R-HSA-170842]
organism-modification
PR:000036408
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human)
hTGFBR2/iso:RII-1/SigPep-
"A TGF-beta receptor type-2 isoform RII-1, signal peptide removed form in human. UniProtKB:P37173-1, 23-567." [PMID:11483955, PMID:11850637, PMID:1310899, PMID:1850637, PMID:8774881, PRO:CNA]
Yes
organism-modification
PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human)
hTGFBR2/iso:RII-1/SigPep-/Phos:1
"A TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 in human. UniProtKB:P37173-1, 23-567, Ser-213/Ser-409, MOD:00046|Tyr-259/Tyr-336/Tyr-424, MOD:00048." [PID:TGFB/TGFBR2/TGFBR1]
Yes
organism-modification
PR:000049434
TGF-beta receptor type-2, signal peptide removed neddylated 1 (human)
hTGFBR2/SigPep-/Nedd:1
"A TGF-beta receptor type-2 (human) that has had the signal peptide removed and has been post-translationally modified to include neddylated lysine at positions 556 and 567 of the amino acid sequence represented by UniProtKB:P37173. UniProtKB:P37173, 23-567, Lys-556/Lys-567, MOD:01150." [PRO:DNx, Reactome:R-HSA-4332222]
organism-modification
PR:000060724
TGF-beta receptor type-2 sequence variant Y470D, signal peptide removed form (human)
hTGFBR2/var:Y470D/SigPep-
"A TGF-beta receptor type-2 (human) that has an Asp residue at the position equivalent to Tyr-470 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Tyr-470, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-3640905]
organism-modification
PR:000062611
TGF-beta receptor type-2 sequence variant E526Q, signal peptide removed form (human)
hTGFBR2/var:E526Q/SigPep-
"A TGF-beta receptor type-2 (human) that has a Gln residue at the position equivalent to Glu-526 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Glu-526, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-3645770]
organism-modification
PR:000062709
TGF-beta receptor type-2 sequence variant R528C, signal peptide removed form (human)
hTGFBR2/var:R528C/SigPep-
"A TGF-beta receptor type-2 (human) that has a Cys residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Arg-528, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-3640899]
organism-modification
PR:000062958
TGF-beta receptor type-2 sequence variant D522N, signal peptide removed form (human)
hTGFBR2/var:D522N/SigPep-
"A TGF-beta receptor type-2 (human) that has an Asn residue at the position equivalent to Asp-522 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Asp-522, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-3640907]
organism-modification
PR:000064130
TGF-beta receptor type-2 sequence variant R528H, signal peptide removed form (human)
hTGFBR2/var:R528H/SigPep-
"A TGF-beta receptor type-2 (human) that has a His residue at the position equivalent to Arg-528 of the amino acid sequence represented by UniProtKB:P37173-1 and that has had the signal peptide removed. Example: UniProtKB:P37173-1, 23-567, Arg-528, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-3640894]
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hTGFBR2/SigPep-
forms found in complexes
hTGFBR2/SigPep-
Component
Complexes
PR:000025962
hTGFBR2/iso:RII-1/SigPep-/Phos:1
PR:000025963
transforming growth factor beta type II receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036408
hTGFBR2/iso:RII-1/SigPep-
UniProtKB:P37173-1, 23-567
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11483955
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:1310899
;
PMID:8774881
enables
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:11483955
GO:0005515
protein binding
with
PR:000000634
TGFB3/iso:1/Clv:1
PMID:1850637
GO:0005515
protein binding
PMID:1850637
GO:0050431
transforming growth factor beta binding
PMID:11850637
;
PMID:1310899
located_in
GO:0016020
membrane
PMID:1310899
