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Protein Ontology report - L-lactate dehydrogenase, cytoplasmic
PR:000050332 - http://purl.obolibrary.org/obo/PR_000050332
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000050332   
  PRO nameL-lactate dehydrogenase, cytoplasmic 
  Synonyms
PRO-Short-label: EXACT:LDH-cyto
  Definition"A protein that is a translation product of the Schizosaccharomyces pombe SPAC186.08c gene, a 1:1 ortholog thereof, or pro-orthologs thereof." [PRO:DAN] 
  CommentPro-orthology refers to, in this case, after-speciation gene duplication in the non-yeast species (aka 1:many orthology). 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene6                                                  Organism-Gene 20                                        
         Sequence2                                                  Organism-Sequence 9                                        
         Modification3                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000050332

L-lactate dehydrogenase, cytoplasmic

LDH-cyto


"A protein that is a translation product of the Schizosaccharomyces pombe SPAC186.08c gene, a 1:1 ortholog thereof, or pro-orthologs thereof." [PRO:DAN]


Yes
gene



PR:000009739

L-lactate dehydrogenase A chain

LDHA


"An L-lactate dehydrogenase, cytoplasmic that is a translation product of the human LDHA gene or a 1:1 ortholog thereof." [PRO:DNx]


Yes
organism-gene



PR:P00338

L-lactate dehydrogenase A chain (human)

hLDHA


"An L-lactate dehydrogenase A chain that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00338]


organism-sequence



PR:P00338-1

L-lactate dehydrogenase A chain isoform h1 (human)

hLDHA/iso:h1


"An L-lactate dehydrogenase A chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00338-1." [PRO:DNx, UniProtKB:P00338]


organism-sequence



PR:P00338-2

L-lactate dehydrogenase A chain isoform h2 (human)

hLDHA/iso:h2


"An L-lactate dehydrogenase A chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00338-2." [PRO:DNx, UniProtKB:P00338]


organism-sequence



PR:P00338-3

L-lactate dehydrogenase A chain isoform h3 (human)

hLDHA/iso:h3


"An L-lactate dehydrogenase A chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00338-3." [PRO:DNx, UniProtKB:P00338]


organism-sequence



PR:P00338-4

L-lactate dehydrogenase A chain isoform h4 (human)

hLDHA/iso:h4


"An L-lactate dehydrogenase A chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00338-4." [PRO:DNx, UniProtKB:P00338]


organism-sequence



PR:P00338-5

L-lactate dehydrogenase A chain isoform h5 (human)

hLDHA/iso:h5


"An L-lactate dehydrogenase A chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00338-5." [PRO:DNx, UniProtKB:P00338]


organism-modification



PR:000048179

L-lactate dehydrogenase A chain, initiator methionine removed form (human)

hLDHA/InitMet-


"An L-lactate dehydrogenase A chain (human) that has had the initiator methionine removed. UniProtKB:P00338, 2-332." [PRO:DNx, Reactome:R-HSA-70502]


Yes
organism-modification



PR:000068524

L-lactate dehydrogenase A chain methylated 1 (human)

hLDHA/Me:1


"An L-lactate dehydrogenase A chain (human) that has been methylated on the residue at the position equivalent to Cys-293 of the amino acid sequence represented by UniProtKB:P00338-1. Example: UniProtKB:P00338-1, Cys-293, MOD:00660." [IEDB_epitope:1057360, PRO:DNx]


organism-modification



PR:000072366

L-lactate dehydrogenase A chain glutathionylated 1 (human)

hLDHA/SGlt:1


"An L-lactate dehydrogenase A chain (human) that has been glutathionylated on the residue at the position equivalent to Cys-131 of the amino acid sequence represented by UniProtKB:P00338-1. Example: UniProtKB:P00338-1, Cys-131, MOD:00234." [IEDB_epitope:744608, PRO:DNx]


organism-modification



PR:000074825

L-lactate dehydrogenase A chain deaminated 1 (human)

hLDHA/Deam:1


"An L-lactate dehydrogenase A chain (human) that has been deaminated on the residue at the position equivalent to Gln-111 of the amino acid sequence represented by UniProtKB:P00338-1. Example: UniProtKB:P00338-1, Gln-111, MOD:00685." [IEDB_epitope:1990225, PRO:DNx]


organism-modification



PR:000082679

L-lactate dehydrogenase A chain hydroxylated 1 (human)

hLDHA/Hy:1


"An L-lactate dehydrogenase A chain (human) that has been hydroxylated on the residue at the position equivalent to Trp-324 of the amino acid sequence represented by UniProtKB:P00338-1. Example: UniProtKB:P00338-1, Trp-324, MOD:01622." [IEDB_epitope:1325702, PRO:DNx]


organism-modification



PR:000082816

L-lactate dehydrogenase A chain methylated 2 (human)

hLDHA/Me:2


"An L-lactate dehydrogenase A chain (human) that has been methylated on the residue at the position equivalent to Cys-131 of the amino acid sequence represented by UniProtKB:P00338-1. Example: UniProtKB:P00338-1, Cys-131, MOD:00660." [IEDB_epitope:1027996, IEDB_epitope:1027997, IEDB_epitope:1050797, IEDB_epitope:1062532, PRO:DNx]


organism-modification



PR:000083019

L-lactate dehydrogenase A chain cysteinylated 1 (human)

hLDHA/Cyst:1


"An L-lactate dehydrogenase A chain (human) that has been cysteinylated on the residue at the position equivalent to Cys-293 of the amino acid sequence represented by UniProtKB:P00338-1. Example: UniProtKB:P00338-1, Cys-293, MOD:00765." [IEDB_epitope:1057359, PRO:DNx]


organism-gene



PR:P00340

L-lactate dehydrogenase A chain (chicken)

chick-LDHA


"An L-lactate dehydrogenase A chain that is encoded in the genome of chicken." [OMA:P00340, PRO:DNx]


organism-gene



PR:P04642

L-lactate dehydrogenase A chain (rat)

rLDHA


"An L-lactate dehydrogenase A chain that is encoded in the genome of rat." [OMA:P04642, PRO:DNx]


organism-gene



PR:P06151

L-lactate dehydrogenase A chain (mouse)

mLDHA


"An L-lactate dehydrogenase A chain that is encoded in the genome of mouse." [OMA:P06151, PRO:DAN]


organism-gene



PR:Q27888

L-lactate dehydrogenase (worm)

LDHA (worm)


"An L-lactate dehydrogenase A chain that is encoded in the genome of worm." [OMA:Q27888, PRO:DNx]


organism-gene



PR:Q95028

L-lactate dehydrogenase (fruit fly)

fly-LDHA


"An L-lactate dehydrogenase A chain that is encoded in the genome of fruit fly." [OMA:Q95028, PRO:DNx]


organism-gene



PR:Q9P7P7

probable L-lactate dehydrogenase (Schizosaccharomyces pombe 972h-)

Spom972h-LDHA


"An L-lactate dehydrogenase A chain that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:DNx]


organism-gene



PR:Q9PVK5

L-lactate dehydrogenase A chain (zebrafish)

z-ldha


"An L-lactate dehydrogenase A chain that is a translation product of the ldha gene in zebrafish." [PRO:DNx, UniProtKB:Q9PVK5]


modification



PR:000020451

L-lactate dehydrogenase A chain, initiator methionine removed form

LDHA/InitMet-


"An L-lactate dehydrogenase A chain that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000048179

L-lactate dehydrogenase A chain, initiator methionine removed form (human)

hLDHA/InitMet-


"An L-lactate dehydrogenase A chain (human) that has had the initiator methionine removed. UniProtKB:P00338, 2-332." [PRO:DNx, Reactome:R-HSA-70502]


Yes
gene



PR:000009740

L-lactate dehydrogenase A-like 6A

LDHAL6A


"An L-lactate dehydrogenase, cytoplasmic that is a translation product of the human LDHAL6A gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q6ZMR3

L-lactate dehydrogenase A-like 6A (human)

hLDHAL6A


"An L-lactate dehydrogenase A-like 6A that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q6ZMR3]


organism-modification



PR:000048180

L-lactate dehydrogenase A-like 6A, initiator methionine removed form (human)

hLDHAL6A/InitMet-


"An L-lactate dehydrogenase A-like 6A (human) that has had the initiator methionine removed. UniProtKB:Q6ZMR3, 2-332." [PRO:DNx, Reactome:R-HSA-6807602]


gene



PR:000009741

L-lactate dehydrogenase A-like 6B

LDHAL6B


"An L-lactate dehydrogenase, cytoplasmic that is a translation product of the human LDHAL6B gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q9BYZ2

L-lactate dehydrogenase A-like 6B (human)

hLDHAL6B


"An L-lactate dehydrogenase A-like 6B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9BYZ2]


gene



PR:000009742

L-lactate dehydrogenase B chain

LDHB


"An L-lactate dehydrogenase, cytoplasmic that is a translation product of the human LDHB gene, a 1:1 ortholog thereof, or pro-orthologs thereof." [PRO:DNx]


Yes
organism-gene



PR:P00336

L-lactate dehydrogenase B chain (pig)

pig-LDHB


"An L-lactate dehydrogenase B chain that is encoded in the genome of pig." [PRO:DNx, UniProtKB:P00336]


organism-gene



PR:P00337

L-lactate dehydrogenase B chain (chicken)

chick-LDHB


"An L-lactate dehydrogenase B chain that is encoded in the genome of chicken." [PRO:DNx]


organism-gene



PR:P07195

L-lactate dehydrogenase B chain (human)

hLDHB


"An L-lactate dehydrogenase B chain that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07195]


organism-sequence



PR:P07195-1

L-lactate dehydrogenase B chain isoform 1 (human)

hLDHB/iso:1


"An L-lactate dehydrogenase B chain isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000048181

L-lactate dehydrogenase B chain, initiator methionine removed form (human)

hLDHB/InitMet-


"An L-lactate dehydrogenase B chain (human) that has had the initiator methionine removed. UniProtKB:P07195, 2-334." [PRO:DNx, Reactome:R-HSA-70503]


Yes
organism-modification



PR:000069763

L-lactate dehydrogenase B chain deaminated 1 (human)

hLDHB/Deam:1


"An L-lactate dehydrogenase B chain (human) that has been deaminated on the residue at the position equivalent to Gln-102 of the amino acid sequence represented by UniProtKB:P07195. UniProtKB:P07195, Gln-102, MOD:00685." [IEDB_epitope:1586938, PRO:DNx]


organism-modification



PR:000078749

L-lactate dehydrogenase B chain cysteinylated 1 (human)

hLDHB/Cyst:1


"An L-lactate dehydrogenase B chain (human) that has been cysteinylated on the residue at the position equivalent to Cys-132 of the amino acid sequence represented by UniProtKB:P07195. UniProtKB:P07195, Cys-132, MOD:00765." [IEDB_epitope:1587957, PRO:DNx]


organism-gene



PR:P16125

L-lactate dehydrogenase B chain (mouse)

mLDHB


"An L-lactate dehydrogenase B chain that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P16125-1

L-lactate dehydrogenase B chain isoform 1 (mouse)

mLDHB/iso:1


"An L-lactate dehydrogenase B chain isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:P42123

L-lactate dehydrogenase B chain (rat)

rLDHB


"An L-lactate dehydrogenase B chain that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:P42123-1

L-lactate dehydrogenase B chain isoform 1 (rat)

rLDHB/iso:1


"An L-lactate dehydrogenase B chain isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q6DGK2

L-lactate dehydrogenase B-B chain (zebrafish)

z-ldhbb


"An L-lactate dehydrogenase B chain that is a translation product of the ldhbb gene in zebrafish." [PRO:DNx, UniProtKB:Q6DGK2]


organism-gene



PR:Q9PVK4

L-lactate dehydrogenase B-A chain (zebrafish)

z-ldhba


"An L-lactate dehydrogenase B chain that is a translation product of the ldhba gene in zebrafish." [PRO:DNx, UniProtKB:Q9PVK4]


sequence



PR:000038703

L-lactate dehydrogenase B chain isoform 1

LDHB/iso:1


"An L-lactate dehydrogenase B chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07195-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P07195-1

L-lactate dehydrogenase B chain isoform 1 (human)

hLDHB/iso:1


"An L-lactate dehydrogenase B chain isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P16125-1

L-lactate dehydrogenase B chain isoform 1 (mouse)

mLDHB/iso:1


"An L-lactate dehydrogenase B chain isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P42123-1

L-lactate dehydrogenase B chain isoform 1 (rat)

rLDHB/iso:1


"An L-lactate dehydrogenase B chain isoform 1 that is encoded in the genome of rat." [PRO:DNx]


modification



PR:000020452

L-lactate dehydrogenase B chain, initiator methionine removed form

LDHB/InitMet-


"An L-lactate dehydrogenase B chain that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000048181

L-lactate dehydrogenase B chain, initiator methionine removed form (human)

hLDHB/InitMet-


"An L-lactate dehydrogenase B chain (human) that has had the initiator methionine removed. UniProtKB:P07195, 2-334." [PRO:DNx, Reactome:R-HSA-70503]


Yes
gene



PR:000009743

L-lactate dehydrogenase C chain

LDHC


"An L-lactate dehydrogenase, cytoplasmic that is a translation product of the human LDHC gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P00342

L-lactate dehydrogenase C chain (mouse)

mLDHC


"An L-lactate dehydrogenase C chain that is encoded in the genome of mouse." [OMA:P00342, PRO:DNx]


organism-sequence



PR:P00342-1

L-lactate dehydrogenase C chain isoform 1 (mouse)

mLDHC/iso:1


"An L-lactate dehydrogenase C chain isoform 1 that is encoded in the genome of mouse." [PMID:343385, PMID:468774, PMID:7429427, PRO:HJD]

Yes

organism-gene



PR:P07864

L-lactate dehydrogenase C chain (human)

hLDHC


"An L-lactate dehydrogenase C chain that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07864]


organism-gene



PR:P19629

L-lactate dehydrogenase C chain (rat)

rLDHC


"An L-lactate dehydrogenase C chain that is encoded in the genome of rat." [PRO:DNx]


sequence



PR:000028631

L-lactate dehydrogenase C chain isoform 1

LDHC/iso:1


"An L-lactate dehydrogenase C chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00342-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P00342-1

L-lactate dehydrogenase C chain isoform 1 (mouse)

mLDHC/iso:1


"An L-lactate dehydrogenase C chain isoform 1 that is encoded in the genome of mouse." [PMID:343385, PMID:468774, PMID:7429427, PRO:HJD]

Yes

modification



PR:000020453

L-lactate dehydrogenase C chain, initiator methionine removed form

LDHC/InitMet-


"An L-lactate dehydrogenase C chain that has had the initiator methionine removed." [PRO:DNx]


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LDH-cyto forms found in complexes   

LDH-cyto Component
Complexes
PR:000009739 LDHA PR:000050327 lactate dehydrogenase complex 2
PR:000050328 lactate dehydrogenase complex 3
PR:000050329 lactate dehydrogenase complex 4
PR:000050330 lactate dehydrogenase complex 5
PR:000009742 LDHB PR:000050326 lactate dehydrogenase complex 1
PR:000050327 lactate dehydrogenase complex 2
PR:000050328 lactate dehydrogenase complex 3
PR:000050329 lactate dehydrogenase complex 4
PR:000048179 hLDHA/InitMet- PR:000050363 lactate dehydrogenase complex 2 (human)
PR:000050364 lactate dehydrogenase complex 3 (human)
PR:000050365 lactate dehydrogenase complex 4 (human)
PR:000050366 lactate dehydrogenase complex 5 (human)
PR:000048181 hLDHB/InitMet- PR:000050362 lactate dehydrogenase complex 1 (human)
PR:000050363 lactate dehydrogenase complex 2 (human)
PR:000050364 lactate dehydrogenase complex 3 (human)
PR:000050365 lactate dehydrogenase complex 4 (human)
PR:000050332 LDH-cyto PR:000050331 lactate dehydrogenase complex
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P00342-1 mLDHC/iso:1 acts_upstream_of_or_withinGO:0006089 lactate metabolic process PMID:18367675
GO:0006090 pyruvate metabolic process PMID:18367675
enablesGO:0004459 L-lactate dehydrogenase (NAD+) activity PMID:18367675
located_inGO:0005737 cytoplasm PMID:18367675
GO:0031514 motile cilium PMID:18367675