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Protein Ontology report - ROBO protein
PR:000050051 - http://purl.obolibrary.org/obo/PR_000050051
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000050051   
  PRO nameROBO protein 
  Synonyms
PRO-Short-label: EXACT:fam:ROBO
  Definition"A protein that is a translation product of the human ROBO1, ROBO2, ROBO3, or ROBO4 genes, or 1:1 orthologs thereof." [PRO:DAN] 
  CommentRequested by=CRAFT. 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 10                                        
         Sequence2                                                  Organism-Sequence 26                                        
         Modification0                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000050051

ROBO protein

fam:ROBO


"A protein that is a translation product of the human ROBO1, ROBO2, ROBO3, or ROBO4 genes, or 1:1 orthologs thereof." [PRO:DAN]


gene



PR:000014151

roundabout homolog 1

ROBO1


"A ROBO protein that is a translation product of the human ROBO1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O55005

roundabout homolog 1 (rat)

rROBO1


"A roundabout homolog 1 that is encoded in the genome of rat." [OMA:O55005, PRO:DNx]


organism-gene



PR:O89026

roundabout homolog 1 (mouse)

mROBO1


"A roundabout homolog 1 that is encoded in the genome of mouse." [OMA:O89026, PRO:DNx]


organism-gene



PR:Q9Y6N7

roundabout homolog 1 (human)

hROBO1


"A roundabout homolog 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9Y6N7]


organism-sequence



PR:Q9Y6N7-1

roundabout homolog 1 isoform h1 (human)

hROBO1/iso:h1


"A roundabout homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6N7-1." [PRO:DNx, UniProtKB:Q9Y6N7]


organism-sequence



PR:Q9Y6N7-2

roundabout homolog 1 isoform h2 (human)

hROBO1/iso:h2


"A roundabout homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6N7-2." [PRO:DNx, UniProtKB:Q9Y6N7]


organism-sequence



PR:Q9Y6N7-3

roundabout homolog 1 isoform h3 (human)

hROBO1/iso:h3


"A roundabout homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6N7-3." [PRO:DNx, UniProtKB:Q9Y6N7]


organism-sequence



PR:Q9Y6N7-4

roundabout homolog 1 isoform h4 (human)

hROBO1/iso:h4


"A roundabout homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6N7-4." [PRO:DNx, UniProtKB:Q9Y6N7]


organism-sequence



PR:Q9Y6N7-5

roundabout homolog 1 isoform h5 (human)

hROBO1/iso:h5


"A roundabout homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6N7-5." [PRO:DNx, UniProtKB:Q9Y6N7]


organism-sequence



PR:Q9Y6N7-6

roundabout homolog 1 isoform h6 (human)

hROBO1/iso:h6


"A roundabout homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6N7-6." [PRO:DNx, UniProtKB:Q9Y6N7]


organism-modification



PR:000049058

roundabout homolog 1, signal peptide removed form (human)

hROBO1/SigPep-


"A roundabout homolog 1 (human) that has had the signal peptide removed. UniProtKB:Q9Y6N7, 26-1651." [PRO:DNx, Reactome:R-HSA-204361]


organism-modification



PR:000049059

roundabout homolog 1, signal peptide removed phosphorylated 1 (human)

hROBO1/SigPep-/Phos:1


"A roundabout homolog 1 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at position 1073 of the amino acid sequence represented by UniProtKB:Q9Y6N7. UniProtKB:Q9Y6N7, 26-1651, Tyr-1073, MOD:00048." [PRO:DNx, Reactome:R-HSA-375979]


organism-modification



PR:000064828

roundabout homolog 1, signal peptide removed ubiquitinated form (human)

hROBO1/SigPep-/UbiqLys+


"A roundabout homolog 1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. Example: UniProtKB:Q9Y6N7-1, 26-1651, MOD:01148." [PRO:DNx, Reactome:R-HSA-8986095]


organism-modification



PR:000058407

roundabout homolog 1 O-glycosylated 1 (human)

hROBO1/OGlyco:1


"A roundabout homolog 1 (human) that has been O-glycosylated at the residue equivalent to Thr-555 of the amino acid sequence represented by UniProtKB:Q9Y6N7-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q9Y6N7-1, Thr-555, MOD:00005~GNO:G43417UB." [GlyGen:Q9Y6N7-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000064828

roundabout homolog 1, signal peptide removed ubiquitinated form (human)

hROBO1/SigPep-/UbiqLys+


"A roundabout homolog 1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. Example: UniProtKB:Q9Y6N7-1, 26-1651, MOD:01148." [PRO:DNx, Reactome:R-HSA-8986095]


organism-modification



PR:000076770

roundabout homolog 1 phosphorylated 1 (human)

hROBO1/Phos:1


"A roundabout homolog 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-1306 of the amino acid sequence represented by UniProtKB:Q9Y6N7-1. Example: UniProtKB:Q9Y6N7-1, Ser-1306, MOD:00046." [IEDB_epitope:848327, PRO:DNx]


organism-modification



PR:000079640

roundabout homolog 1 methylated 1 (human)

hROBO1/Me:1


"A roundabout homolog 1 (human) that has been methylated on the residue at the position equivalent to Cys-1216 of the amino acid sequence represented by UniProtKB:Q9Y6N7-1. Example: UniProtKB:Q9Y6N7-1, Cys-1216, MOD:00660." [IEDB_epitope:1033789, PRO:DNx]


organism-modification



PR:000080668

roundabout homolog 1 methylated 2 (human)

hROBO1/Me:2


"A roundabout homolog 1 (human) that has been methylated on the residue at the position equivalent to Cys-1015 of the amino acid sequence represented by UniProtKB:Q9Y6N7-1. Example: UniProtKB:Q9Y6N7-1, Cys-1015, MOD:00660." [IEDB_epitope:1044071, PRO:DNx]


gene



PR:000014152

roundabout homolog 2

ROBO2


"A ROBO protein that is a translation product of the human ROBO2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q7TPD3

roundabout homolog 2 (mouse)

mROBO2


"A roundabout homolog 2 that is encoded in the genome of mouse." [OMA:Q7TPD3, PRO:DNx]


organism-sequence



PR:Q7TPD3-1

roundabout homolog 2 isoform m1 (mouse)

mROBO2/iso:m1


"A roundabout homolog 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7TPD3-1." [PRO:DNx, UniProtKB:Q7TPD3]


organism-sequence



PR:Q7TPD3-2

roundabout homolog 2 isoform m2 (mouse)

mROBO2/iso:m2


"A roundabout homolog 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7TPD3-2." [PRO:DNx, UniProtKB:Q7TPD3]


organism-gene



PR:Q9HCK4

roundabout homolog 2 (human)

hROBO2


"A roundabout homolog 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HCK4]


organism-sequence



PR:Q9HCK4-1

roundabout homolog 2 isoform h1 (human)

hROBO2/iso:h1


"A roundabout homolog 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCK4-1." [PRO:DNx, UniProtKB:Q9HCK4]


organism-sequence



PR:Q9HCK4-2

roundabout homolog 2 isoform h2 (human)

hROBO2/iso:h2


"A roundabout homolog 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCK4-2." [PRO:DNx, UniProtKB:Q9HCK4]


organism-sequence



PR:Q9HCK4-3

roundabout homolog 2 isoform h3 (human)

hROBO2/iso:h3


"A roundabout homolog 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCK4-3." [PRO:DNx, UniProtKB:Q9HCK4]


organism-modification



PR:000049060

roundabout homolog 2, signal peptide removed form (human)

hROBO2/SigPep-


"A roundabout homolog 2 (human) that has had the signal peptide removed. UniProtKB:Q9HCK4, 22-1378." [PRO:DNx, Reactome:R-HSA-197747]


gene



PR:000014153

roundabout homolog 3

ROBO3


"A ROBO protein that is a translation product of the human ROBO3 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q96MS0

roundabout homolog 3 (human)

hROBO3


"A roundabout homolog 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96MS0]


organism-sequence



PR:F5GWJ5

roundabout homolog 3 isoform ROBO3B.1 (human)

hROBO3/iso:ROBO3B.1


"A roundabout homolog 3 isoform ROBO3B.1 that is encoded in the genome of human." [PMID:16554811, PMID:19690332, PRO:CNA, UniProtKB:F5GWJ5]


organism-sequence



PR:Q96MS0-1

roundabout homolog 3 isoform ROBO3A.1 (human)

hROBO3/iso:ROBO3A.1


"A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of human." [PMID:15105459, PRO:CNA, UniProtKB:Q96MS0]


organism-modification



PR:000060958

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed form (human)

hROBO3/iso:ROBO3A.1/SigPep-


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed. UniProtKB:Q96MS0-1, 21-1386." [PRO:DNx, Reactome:R-HSA-426410]


organism-modification



PR:000061592

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 1 (human)

hROBO3/iso:ROBO3A.1/SigPep-/Phos:1


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Ser-1330 of the amino acid sequence represented by UniProtKB:Q96MS0-1. UniProtKB:Q96MS0-1, 21-1386, Ser-1330, MOD:00046." [PRO:DNx, Reactome:R-HSA-9010775]


organism-modification



PR:000062739

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 2 (human)

hROBO3/iso:ROBO3A.1/SigPep-/Phos:2


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Tyr-1019 of the amino acid sequence represented by UniProtKB:Q96MS0-1. UniProtKB:Q96MS0-1, 21-1386, Tyr-1019, MOD:00048." [PRO:DNx, Reactome:R-HSA-9011239]


organism-modification



PR:000064762

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)

hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q96MS0-1, 21-1386, MOD:01148." [PRO:DNx, Reactome:R-HSA-9011301]


organism-modification



PR:000064762

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)

hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q96MS0-1, 21-1386, MOD:01148." [PRO:DNx, Reactome:R-HSA-9011301]


organism-sequence



PR:Q96MS0-2

roundabout homolog 3 isoform h2 (human)

hROBO3/iso:h2


"A roundabout homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96MS0-2." [PRO:DNx, UniProtKB:Q96MS0]


organism-modification



PR:000081279

roundabout homolog 3 deaminated 1 (human)

hROBO3/Deam:1


"A roundabout homolog 3 (human) that has been deaminated on the residue at the position equivalent to Gln-697 of the amino acid sequence represented by UniProtKB:Q96MS0-1. Example: UniProtKB:Q96MS0-1, Gln-697, MOD:00685." [IEDB_epitope:2144025, PRO:DNx]


organism-gene



PR:Q9Z2I4

roundabout homolog 3 (mouse)

mROBO3


"A roundabout homolog 3 that is encoded in the genome of mouse." [OMA:Q9Z2I4, PRO:DNx]


seqgroup



PR:000037776

roundabout homolog 3 isoform ROBO3B (mouse)

mROBO3/iso:ROBO3B[1/2]


"A roundabout homolog 3 (mouse) that has a shorter N-terminal sequence than ROBO3A forms." [PMID:16226035, PMID:18466743, PRO:CNA]






PR:E9QPQ1

roundabout homolog 3 isoform ROBO3B.1 (mouse)











PR:Q9Z2I4-2

roundabout homolog 3 isoform ROBO3B.2 (mouse)







organism-sequence



PR:D3Z4M6

roundabout homolog 3 isoform ROBO3A.1 (mouse)

mROBO3/iso:ROBO3A1


"A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of mouse. This isoform has a longer N-terminal sequence in comparison with ROBO3B isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats." [PMID:16226035, PRO:KRC, UniProtKB:D3Z4M6]

Yes

organism-sequence



PR:E9QPQ1

roundabout homolog 3 isoform ROBO3B.1 (mouse)

mROBO3/iso:B1


"A roundabout homolog 3 isoform ROBO3B.1 that is encoded in the genome of mouse. This isoform has a shorter N-terminal sequence in comparison with ROBO3A isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats." [PMID:16554811, PMID:18466743, PRO:KRC]


organism-sequence



PR:Q9Z2I4-1

roundabout homolog 3 isoform ROBO3A.2 (mouse)

mROBO3/iso:ROBO3A.2


"A roundabout homolog 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2I4-1. Isoforms ROBO3A have a longer N-terminal sequence than isoforms ROBO3B. Isoforms ROBO3.2 have a unique C-terminal sequence due to retention of the intron between exons 26 and 27." [PMID:16226035, PMID:18466743, PRO:KRC, UniProtKB:Q9Z2I4]


organism-sequence



PR:Q9Z2I4-2

roundabout homolog 3 isoform ROBO3B.2 (mouse)

mROBO3/iso:ROBO3B.2


"A roundabout homolog 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2I4-2. Isoforms ROBO3B have a shorter N-terminal sequence than isoforms ROBO3A. Isoforms ROBO3.2 have a unique C-terminal sequence due to retention of the intron between exons 26 and 27." [PMID:10049565, PMID:16226035, PMID:18466743, PRO:KRC, UniProtKB:Q9Z2I4]


organism-sequence



PR:Q9Z2I4-3

roundabout homolog 3 isoform m1 (mouse)

mROBO3/iso:m1


"A roundabout homolog 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2I4-3." [PRO:DNx, UniProtKB:Q9Z2I4]


organism-sequence



PR:Q9Z2I4-4

roundabout homolog 3 isoform m3 (mouse)

mROBO3/iso:m3


"A roundabout homolog 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2I4-4." [PRO:DNx, UniProtKB:Q9Z2I4]


seqgroup



PR:000037775

roundabout homolog 3 isoform ROBO3A (mouse)

mROBO3/iso:ROBO3A[1/2]


"A roundabout homolog 3 (mouse) that has a longer N-terminal sequence than ROBO3B forms." [PMID:16226035, PMID:18466743, PRO:CNA]






PR:D3Z4M6

roundabout homolog 3 isoform ROBO3A.1 (mouse)











PR:Q9Z2I4-1

roundabout homolog 3 isoform ROBO3A.2 (mouse)







seqgroup



PR:000037777

roundabout homolog 3 isoform ROBO3.1 (mouse)

mROBO3/iso:ROBO3[A/B]1


"A roundabout homolog 3 (mouse) that has a C-terminal sequence that includes the region encoded by exons 26, 27 and 28. The resulting 78 amino acid peptide is highly enriched in arginine/serine dipeptide repeats." [PMID:16554811, PMID:18466743, PRO:KRC]

Yes





PR:D3Z4M6

roundabout homolog 3 isoform ROBO3A.1 (mouse)











PR:E9QPQ1

roundabout homolog 3 isoform ROBO3B.1 (mouse)







seqgroup



PR:000037778

roundabout homolog 3 isoform ROBO3.2 (mouse)

mROBO3/iso:ROBO3[A/B]2


"A roundabout homolog 3 (mouse) that has a unique C-terminal sequence due to retention of the intron between exons 26 and 27." [PMID:16554811, PMID:18466743, PRO:KRC]

Yes





PR:Q9Z2I4-1

roundabout homolog 3 isoform ROBO3A.2 (mouse)











PR:Q9Z2I4-2

roundabout homolog 3 isoform ROBO3B.2 (mouse)







sequence



PR:000037773

roundabout homolog 3 isoform ROBO3A.1

ROBO3/iso:ROBO3A.1


"A roundabout homolog 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96MS0-1 or a 1:1 ortholog thereof. Isoforms ROBO3A have a longer N-terminal sequence than isoforms ROBO3B. Isoforms ROBO3.1 have a C-terminal sequence highly enriched in arginine/serine dipeptide repeats." [PMID:15105459, PMID:16226035, PMID:18466743, PRO:CNA]


organism-sequence



PR:D3Z4M6

roundabout homolog 3 isoform ROBO3A.1 (mouse)

mROBO3/iso:ROBO3A1


"A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of mouse. This isoform has a longer N-terminal sequence in comparison with ROBO3B isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats." [PMID:16226035, PRO:KRC, UniProtKB:D3Z4M6]

Yes

organism-sequence



PR:Q96MS0-1

roundabout homolog 3 isoform ROBO3A.1 (human)

hROBO3/iso:ROBO3A.1


"A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of human." [PMID:15105459, PRO:CNA, UniProtKB:Q96MS0]


organism-modification



PR:000060958

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed form (human)

hROBO3/iso:ROBO3A.1/SigPep-


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed. UniProtKB:Q96MS0-1, 21-1386." [PRO:DNx, Reactome:R-HSA-426410]


organism-modification



PR:000061592

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 1 (human)

hROBO3/iso:ROBO3A.1/SigPep-/Phos:1


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Ser-1330 of the amino acid sequence represented by UniProtKB:Q96MS0-1. UniProtKB:Q96MS0-1, 21-1386, Ser-1330, MOD:00046." [PRO:DNx, Reactome:R-HSA-9010775]


organism-modification



PR:000062739

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 2 (human)

hROBO3/iso:ROBO3A.1/SigPep-/Phos:2


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Tyr-1019 of the amino acid sequence represented by UniProtKB:Q96MS0-1. UniProtKB:Q96MS0-1, 21-1386, Tyr-1019, MOD:00048." [PRO:DNx, Reactome:R-HSA-9011239]


organism-modification



PR:000064762

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)

hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q96MS0-1, 21-1386, MOD:01148." [PRO:DNx, Reactome:R-HSA-9011301]


organism-modification



PR:000064762

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)

hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q96MS0-1, 21-1386, MOD:01148." [PRO:DNx, Reactome:R-HSA-9011301]


sequence



PR:000037774

roundabout homolog 3 isoform ROBO3B.1

ROBO3/iso:ROBO3B.1


"A roundabout homolog 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:E9QPQ1 or a 1:1 ortholog thereof. Isoforms ROBO3B have a shorter N-terminal sequence than isoforms ROBO3A. Isoforms ROBO3.1 have a C-terminal sequence highly enriched in arginine/serine dipeptide repeats." [PMID:18466743, PRO:CNA]


organism-sequence



PR:E9QPQ1

roundabout homolog 3 isoform ROBO3B.1 (mouse)

mROBO3/iso:B1


"A roundabout homolog 3 isoform ROBO3B.1 that is encoded in the genome of mouse. This isoform has a shorter N-terminal sequence in comparison with ROBO3A isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats." [PMID:16554811, PMID:18466743, PRO:KRC]


organism-sequence



PR:F5GWJ5

roundabout homolog 3 isoform ROBO3B.1 (human)

hROBO3/iso:ROBO3B.1


"A roundabout homolog 3 isoform ROBO3B.1 that is encoded in the genome of human." [PMID:16554811, PMID:19690332, PRO:CNA, UniProtKB:F5GWJ5]


gene



PR:000014154

roundabout homolog 4

ROBO4


"A ROBO protein that is a translation product of the human ROBO4 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q80W87

roundabout homolog 4 (rat)

rROBO4


"A roundabout homolog 4 that is encoded in the genome of rat." [OMA:Q80W87, PRO:DNx]


organism-gene



PR:Q8C310

roundabout homolog 4 (mouse)

mROBO4


"A roundabout homolog 4 that is encoded in the genome of mouse." [OMA:Q8C310, PRO:DNx]


organism-sequence



PR:Q8C310-1

roundabout homolog 4 isoform m1 (mouse)

mROBO4/iso:m1


"A roundabout homolog 4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C310-1." [PRO:DNx, UniProtKB:Q8C310]


organism-sequence



PR:Q8C310-2

roundabout homolog 4 isoform m2 (mouse)

mROBO4/iso:m2


"A roundabout homolog 4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C310-2." [PRO:DNx, UniProtKB:Q8C310]


organism-sequence



PR:Q8C310-3

roundabout homolog 4 isoform m3 (mouse)

mROBO4/iso:m3


"A roundabout homolog 4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C310-3." [PRO:DNx, UniProtKB:Q8C310]


organism-modification



PR:000066897

roundabout homolog 4 cysteinylated 1 (mouse)

mROBO4/Cyst:1


"A roundabout homolog 4 (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-845 of the amino acid sequence represented by UniProtKB:Q8C310-1. Example: UniProtKB:Q8C310-1, Cys-845, MOD:00765." [IEDB_epitope:2095510, PRO:DNx]


organism-gene



PR:Q8WZ75

roundabout homolog 4 (human)

hROBO4


"A roundabout homolog 4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8WZ75]


organism-sequence



PR:Q8WZ75-1

roundabout homolog 4 isoform h1 (human)

hROBO4/iso:h1


"A roundabout homolog 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WZ75-1." [PRO:DNx, UniProtKB:Q8WZ75]


organism-sequence



PR:Q8WZ75-2

roundabout homolog 4 isoform h2 (human)

hROBO4/iso:h2


"A roundabout homolog 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WZ75-2." [PRO:DNx, UniProtKB:Q8WZ75]


organism-sequence



PR:Q8WZ75-3

roundabout homolog 4 isoform h3 (human)

hROBO4/iso:h3


"A roundabout homolog 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WZ75-3." [PRO:DNx, UniProtKB:Q8WZ75]


organism-modification



PR:000057769

roundabout homolog 4 O-glycosylated 1 (human)

hROBO4/OGlyco:1


"A roundabout homolog 4 (human) that has been O-glycosylated at the residue equivalent to Thr-232 of the amino acid sequence represented by UniProtKB:Q8WZ75-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:Q8WZ75-1, Thr-232, MOD:00005~GNO:G29068FM." [GlyGen:Q8WZ75-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000057770

roundabout homolog 4 O-glycosylated 2 (human)

hROBO4/OGlyco:2


"A roundabout homolog 4 (human) that has been O-glycosylated at the residue equivalent to Thr-232 of the amino acid sequence represented by UniProtKB:Q8WZ75-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q8WZ75-1, Thr-232, MOD:00005~GNO:G43417UB." [GlyGen:Q8WZ75-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000069838

roundabout homolog 4 deaminated 1 (human)

hROBO4/Deam:1


"A roundabout homolog 4 (human) that has been deaminated on the residue at the position equivalent to Asn-396 of the amino acid sequence represented by UniProtKB:Q8WZ75-1. Example: UniProtKB:Q8WZ75-1, Asn-396, MOD:00684." [IEDB_epitope:2143228, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037777 mROBO3/iso:ROBO3[A/B]1
The resulting 78 amino acid peptide is highly enriched in arginine/serine dipeptide repeats
acts_upstream_of_or_withinGO:0061642 chemoattraction of axon MGI_ref:3834283; PMID:18466743
located_inGO:0030424 axon MGI_ref:3834283; PMID:18466743
PR:000037778 mROBO3/iso:ROBO3[A/B]2 acts_upstream_of_or_withinGO:0061643 chemorepulsion of axon MGI_ref:3834283; PMID:18466743
located_inGO:0030424 axon MGI_ref:3834283; PMID:18466743
PR:D3Z4M6 mROBO3/iso:ROBO3A1
This isoform has a longer N-terminal sequence in comparison with ROBO3B isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats
acts_upstream_of_or_withinGO:0016199 axon midline choice point recognition MGI_ref:3834283; PMID:18466743
GO:0061642 chemoattraction of axon MGI_ref:3834283; PMID:18466743
GO:0071679 commissural neuron axon guidance MGI_ref:3834283; PMID:18466743