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Protein Ontology report - ROBO protein
PR:000050051 - http://purl.obolibrary.org/obo/PR_000050051
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000050051   
  PRO nameROBO protein 
  Synonyms
PRO-Short-label: EXACT:fam:ROBO
  Definition"A protein that is a translation product of the human ROBO1, ROBO2, ROBO3, or ROBO4 genes, or 1:1 orthologs thereof." [PRO:DAN] 
  CommentRequested by=CRAFT. 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 10                                        
         Sequence2                                                  Organism-Sequence 26                                        
         Modification0                                                  Organism-Modification 17                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000050051 ROBO protein
fam:ROBO

gene


PR:000014151 roundabout homolog 1
ROBO1

organism-gene


PR:O55005 roundabout homolog 1 (rat)
rROBO1

organism-gene


PR:O89026 roundabout homolog 1 (mouse)
mROBO1

organism-gene


PR:Q9Y6N7 roundabout homolog 1 (human)
hROBO1

organism-sequence


PR:Q9Y6N7-1 roundabout homolog 1 isoform h1 (human)
hROBO1/iso:h1

organism-sequence


PR:Q9Y6N7-2 roundabout homolog 1 isoform h2 (human)
hROBO1/iso:h2

organism-sequence


PR:Q9Y6N7-3 roundabout homolog 1 isoform h3 (human)
hROBO1/iso:h3

organism-sequence


PR:Q9Y6N7-4 roundabout homolog 1 isoform h4 (human)
hROBO1/iso:h4

organism-sequence


PR:Q9Y6N7-5 roundabout homolog 1 isoform h5 (human)
hROBO1/iso:h5

organism-sequence


PR:Q9Y6N7-6 roundabout homolog 1 isoform h6 (human)
hROBO1/iso:h6

organism-modification


PR:000049058 roundabout homolog 1, signal peptide removed form (human)
hROBO1/SigPep-

organism-modification


PR:000049059 roundabout homolog 1, signal peptide removed phosphorylated 1 (human)
hROBO1/SigPep-/Phos:1

organism-modification


PR:000064828 roundabout homolog 1, signal peptide removed ubiquitinated form (human)
hROBO1/SigPep-/UbiqLys+

organism-modification


PR:000058407 roundabout homolog 1 O-glycosylated 1 (human)
hROBO1/OGlyco:1

organism-modification


PR:000064828 roundabout homolog 1, signal peptide removed ubiquitinated form (human)
hROBO1/SigPep-/UbiqLys+

organism-modification


PR:000076770 roundabout homolog 1 phosphorylated 1 (human)
hROBO1/Phos:1

organism-modification


PR:000079640 roundabout homolog 1 methylated 1 (human)
hROBO1/Me:1

organism-modification


PR:000080668 roundabout homolog 1 methylated 2 (human)
hROBO1/Me:2

gene


PR:000014152 roundabout homolog 2
ROBO2

organism-gene


PR:Q7TPD3 roundabout homolog 2 (mouse)
mROBO2

organism-sequence


PR:Q7TPD3-1 roundabout homolog 2 isoform m1 (mouse)
mROBO2/iso:m1

organism-sequence


PR:Q7TPD3-2 roundabout homolog 2 isoform m2 (mouse)
mROBO2/iso:m2

organism-gene


PR:Q9HCK4 roundabout homolog 2 (human)
hROBO2

organism-sequence


PR:Q9HCK4-1 roundabout homolog 2 isoform h1 (human)
hROBO2/iso:h1

organism-sequence


PR:Q9HCK4-2 roundabout homolog 2 isoform h2 (human)
hROBO2/iso:h2

organism-sequence


PR:Q9HCK4-3 roundabout homolog 2 isoform h3 (human)
hROBO2/iso:h3

organism-modification


PR:000049060 roundabout homolog 2, signal peptide removed form (human)
hROBO2/SigPep-

gene


PR:000014153 roundabout homolog 3
ROBO3

organism-gene


PR:Q96MS0 roundabout homolog 3 (human)
hROBO3

organism-sequence


PR:F5GWJ5 roundabout homolog 3 isoform ROBO3B.1 (human)
hROBO3/iso:ROBO3B.1

organism-sequence


PR:Q96MS0-1 roundabout homolog 3 isoform ROBO3A.1 (human)
hROBO3/iso:ROBO3A.1

organism-modification


PR:000060958 roundabout homolog 3 isoform ROBO3A.1, signal peptide removed form (human)
hROBO3/iso:ROBO3A.1/SigPep-

organism-modification


PR:000061592 roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 1 (human)
hROBO3/iso:ROBO3A.1/SigPep-/Phos:1

organism-modification


PR:000062739 roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 2 (human)
hROBO3/iso:ROBO3A.1/SigPep-/Phos:2

organism-modification


PR:000064762 roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)
hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+

organism-modification


PR:000064762 roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)
hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+

organism-sequence


PR:Q96MS0-2 roundabout homolog 3 isoform h2 (human)
hROBO3/iso:h2

organism-modification


PR:000081279 roundabout homolog 3 deaminated 1 (human)
hROBO3/Deam:1

organism-gene


PR:Q9Z2I4 roundabout homolog 3 (mouse)
mROBO3

seqgroup


PR:000037776 roundabout homolog 3 isoform ROBO3B (mouse)
mROBO3/iso:ROBO3B[1/2]





PR:E9QPQ1 roundabout homolog 3 isoform ROBO3B.1 (mouse)





PR:Q9Z2I4-2 roundabout homolog 3 isoform ROBO3B.2 (mouse)

organism-sequence


PR:D3Z4M6 roundabout homolog 3 isoform ROBO3A.1 (mouse)
mROBO3/iso:ROBO3A1
Yes
organism-sequence


PR:E9QPQ1 roundabout homolog 3 isoform ROBO3B.1 (mouse)
mROBO3/iso:B1

organism-sequence


PR:Q9Z2I4-1 roundabout homolog 3 isoform ROBO3A.2 (mouse)
mROBO3/iso:ROBO3A.2

organism-sequence


PR:Q9Z2I4-2 roundabout homolog 3 isoform ROBO3B.2 (mouse)
mROBO3/iso:ROBO3B.2

organism-sequence


PR:Q9Z2I4-3 roundabout homolog 3 isoform m1 (mouse)
mROBO3/iso:m1

organism-sequence


PR:Q9Z2I4-4 roundabout homolog 3 isoform m3 (mouse)
mROBO3/iso:m3

seqgroup


PR:000037775 roundabout homolog 3 isoform ROBO3A (mouse)
mROBO3/iso:ROBO3A[1/2]





PR:D3Z4M6 roundabout homolog 3 isoform ROBO3A.1 (mouse)





PR:Q9Z2I4-1 roundabout homolog 3 isoform ROBO3A.2 (mouse)

seqgroup


PR:000037777 roundabout homolog 3 isoform ROBO3.1 (mouse)
mROBO3/iso:ROBO3[A/B]1
Yes




PR:D3Z4M6 roundabout homolog 3 isoform ROBO3A.1 (mouse)





PR:E9QPQ1 roundabout homolog 3 isoform ROBO3B.1 (mouse)

seqgroup


PR:000037778 roundabout homolog 3 isoform ROBO3.2 (mouse)
mROBO3/iso:ROBO3[A/B]2
Yes




PR:Q9Z2I4-1 roundabout homolog 3 isoform ROBO3A.2 (mouse)





PR:Q9Z2I4-2 roundabout homolog 3 isoform ROBO3B.2 (mouse)

sequence


PR:000037773 roundabout homolog 3 isoform ROBO3A.1
ROBO3/iso:ROBO3A.1

organism-sequence


PR:D3Z4M6 roundabout homolog 3 isoform ROBO3A.1 (mouse)
mROBO3/iso:ROBO3A1
Yes
organism-sequence


PR:Q96MS0-1 roundabout homolog 3 isoform ROBO3A.1 (human)
hROBO3/iso:ROBO3A.1

organism-modification


PR:000060958 roundabout homolog 3 isoform ROBO3A.1, signal peptide removed form (human)
hROBO3/iso:ROBO3A.1/SigPep-

organism-modification


PR:000061592 roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 1 (human)
hROBO3/iso:ROBO3A.1/SigPep-/Phos:1

organism-modification


PR:000062739 roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 2 (human)
hROBO3/iso:ROBO3A.1/SigPep-/Phos:2

organism-modification


PR:000064762 roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)
hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+

organism-modification


PR:000064762 roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)
hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+

sequence


PR:000037774 roundabout homolog 3 isoform ROBO3B.1
ROBO3/iso:ROBO3B.1

organism-sequence


PR:E9QPQ1 roundabout homolog 3 isoform ROBO3B.1 (mouse)
mROBO3/iso:B1

organism-sequence


PR:F5GWJ5 roundabout homolog 3 isoform ROBO3B.1 (human)
hROBO3/iso:ROBO3B.1

gene


PR:000014154 roundabout homolog 4
ROBO4

organism-gene


PR:Q80W87 roundabout homolog 4 (rat)
rROBO4

organism-gene


PR:Q8C310 roundabout homolog 4 (mouse)
mROBO4

organism-sequence


PR:Q8C310-1 roundabout homolog 4 isoform m1 (mouse)
mROBO4/iso:m1

organism-sequence


PR:Q8C310-2 roundabout homolog 4 isoform m2 (mouse)
mROBO4/iso:m2

organism-sequence


PR:Q8C310-3 roundabout homolog 4 isoform m3 (mouse)
mROBO4/iso:m3

organism-modification


PR:000066897 roundabout homolog 4 cysteinylated 1 (mouse)
mROBO4/Cyst:1

organism-gene


PR:Q8WZ75 roundabout homolog 4 (human)
hROBO4

organism-sequence


PR:Q8WZ75-1 roundabout homolog 4 isoform h1 (human)
hROBO4/iso:h1

organism-sequence


PR:Q8WZ75-2 roundabout homolog 4 isoform h2 (human)
hROBO4/iso:h2

organism-sequence


PR:Q8WZ75-3 roundabout homolog 4 isoform h3 (human)
hROBO4/iso:h3

organism-modification


PR:000057769 roundabout homolog 4 O-glycosylated 1 (human)
hROBO4/OGlyco:1

organism-modification


PR:000057770 roundabout homolog 4 O-glycosylated 2 (human)
hROBO4/OGlyco:2

organism-modification


PR:000069838 roundabout homolog 4 deaminated 1 (human)
hROBO4/Deam:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037777 mROBO3/iso:ROBO3[A/B]1
The resulting 78 amino acid peptide is highly enriched in arginine/serine dipeptide repeats		 acts_upstream_of_or_withinGO:0061642 chemoattraction of axon MGI_ref:3834283; PMID:18466743
located_inGO:0030424 axon MGI_ref:3834283; PMID:18466743
PR:000037778 mROBO3/iso:ROBO3[A/B]2 acts_upstream_of_or_withinGO:0061643 chemorepulsion of axon MGI_ref:3834283; PMID:18466743
located_inGO:0030424 axon MGI_ref:3834283; PMID:18466743
PR:D3Z4M6 mROBO3/iso:ROBO3A1
This isoform has a longer N-terminal sequence in comparison with ROBO3B isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats		 acts_upstream_of_or_withinGO:0016199 axon midline choice point recognition MGI_ref:3834283; PMID:18466743
GO:0061642 chemoattraction of axon MGI_ref:3834283; PMID:18466743
GO:0071679 commissural neuron axon guidance MGI_ref:3834283; PMID:18466743