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Protein Ontology report - profilin
PR:000050050 - http://purl.obolibrary.org/obo/PR_000050050
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000050050   
  PRO nameprofilin 
  Synonyms
PRO-Short-label: EXACT:fam:PFN
  Definition"A protein that is a translation product of the human PFN1, PFN2, PFN3, or PFN4 genes, or 1:1 orthologs thereof." [PRO:DAN] 
  CommentRequested by=CRAFT. 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 15                                        
         Sequence5                                                  Organism-Sequence 14                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000050050

profilin

fam:PFN


"A protein that is a translation product of the human PFN1, PFN2, PFN3, or PFN4 genes, or 1:1 orthologs thereof." [PRO:DAN]


gene



PR:000012585

profilin-1

PFN1


"A profilin that is a translation product of the human PFN1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P07737

profilin-1 (human)

hPFN1


"A profilin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07737]


organism-sequence



PR:P07737-1

profilin-1 isoform 1 (human)

hPFN1/iso:1


"A profilin-1 isoform 1 that is encoded in the genome of human." [PMID:18829504, SALO:AJ]

Yes

organism-modification



PR:000048752

profilin-1, initiator methionine removed form (human)

hPFN1/InitMet-


"A profilin-1 (human) that has had the initiator methionine removed. UniProtKB:P07737, 2-140." [PRO:DNx, Reactome:R-HSA-203081, Reactome:R-HSA-350755]


organism-modification



PR:000068365

profilin-1 deaminated 1 (human)

hPFN1/Deam:1


"A profilin-1 (human) that has been deaminated on the residue at the position equivalent to Gln-80 of the amino acid sequence represented by UniProtKB:P07737. UniProtKB:P07737, Gln-80, MOD:00685." [IEDB_epitope:1566124, PRO:DNx]


organism-modification



PR:000081709

profilin-1 methylated 1 (human)

hPFN1/Me:1


"A profilin-1 (human) that has been methylated on the residue at the position equivalent to Cys-128 of the amino acid sequence represented by UniProtKB:P07737. UniProtKB:P07737, Cys-128, MOD:00660." [IEDB_epitope:1004412, PRO:DNx]


organism-modification



PR:000083329

profilin-1 cysteinylated 1 (human)

hPFN1/Cyst:1


"A profilin-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-128 of the amino acid sequence represented by UniProtKB:P07737. UniProtKB:P07737, Cys-128, MOD:00765." [IEDB_epitope:2122164, PRO:DNx]


organism-gene



PR:P62962

profilin-1 (mouse)

mPFN1


"A profilin-1 that is encoded in the genome of mouse." [OMA:P62962, PRO:DNx]


organism-sequence



PR:P62962-1

profilin-1 isoform 1 (mouse)

mPFN1/iso:1


"A profilin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:P62963

profilin-1 (rat)

rPFN1


"A profilin-1 that is encoded in the genome of rat." [OMA:P62963, PRO:DNx]


sequence



PR:000025644

profilin-1 isoform 1

PFN1/iso:1


"A profilin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07737-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P07737-1

profilin-1 isoform 1 (human)

hPFN1/iso:1


"A profilin-1 isoform 1 that is encoded in the genome of human." [PMID:18829504, SALO:AJ]

Yes

organism-sequence



PR:P62962-1

profilin-1 isoform 1 (mouse)

mPFN1/iso:1


"A profilin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000026622

profilin-1 isoform 1, initiator methionine removed form

PFN1/iso:1/InitMet-


"A profilin-1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000020937

profilin-1, initiator methionine removed form

PFN1/InitMet-


"A profilin-1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026622

profilin-1 isoform 1, initiator methionine removed form

PFN1/iso:1/InitMet-


"A profilin-1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000048752

profilin-1, initiator methionine removed form (human)

hPFN1/InitMet-


"A profilin-1 (human) that has had the initiator methionine removed. UniProtKB:P07737, 2-140." [PRO:DNx, Reactome:R-HSA-203081, Reactome:R-HSA-350755]


gene



PR:000012586

profilin-2

PFN2


"A profilin that is a translation product of the human PFN2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P35080

profilin-2 (human)

hPFN2


"A profilin-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P35080]


organism-sequence



PR:P35080-1

profilin-2 isoform 1 (human)

hPFN2/iso:1


"A profilin-2 isoform 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35080]


organism-sequence



PR:P35080-2

profilin-2 isoform 2 (human)

hPFN2/iso:2


"A profilin-2 isoform 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35080]


organism-gene



PR:Q9EPC6

profilin-2 (rat)

rPFN2


"A profilin-2 that is encoded in the genome of rat." [OMA:Q9EPC6, PRO:DNx]


organism-sequence



PR:Q9EPC6-1

profilin-2 isoform IIa (rat)

rPFN2/iso:IIa


"A profilin-2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EPC6-1." [PRO:DNx, UniProtKB:Q9EPC6]


organism-sequence



PR:Q9EPC6-2

profilin-2 isoform IIb (rat)

rPFN2/iso:IIb


"A profilin-2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EPC6-2." [PRO:DNx, UniProtKB:Q9EPC6]


organism-gene



PR:Q9JJV2

profilin-2 (mouse)

mPFN2


"A profilin-2 that is encoded in the genome of mouse." [OMA:Q9JJV2, PRO:DNx]


organism-sequence



PR:Q9JJV2-1

profilin-2 isoform 1 (mouse)

mPFN2/iso:1


"A profilin-2 isoform 1 that is encoded in the genome of mouse." [PMID:11034907, PRO:HJD]

Yes

organism-sequence



PR:Q9JJV2-2

profilin-2 isoform 2 (mouse)

mPFN2/iso:2


"A profilin-2 isoform 2 that is encoded in the genome of mouse." [PMID:11034907, PRO:HJD]


organism-sequence



PR:Q9JJV2-3

profilin-2 isoform m3 (mouse)

mPFN2/iso:m3


"A profilin-2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJV2-3." [PRO:DNx, UniProtKB:Q9JJV2]


sequence



PR:000037455

profilin-2 isoform 1

PFN2/iso:1


"A profilin-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJV2-1 or a 1:1 ortholog thereof." [PMID:11034907, PRO:HJD]


organism-sequence



PR:P35080-1

profilin-2 isoform 1 (human)

hPFN2/iso:1


"A profilin-2 isoform 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35080]


organism-sequence



PR:Q9JJV2-1

profilin-2 isoform 1 (mouse)

mPFN2/iso:1


"A profilin-2 isoform 1 that is encoded in the genome of mouse." [PMID:11034907, PRO:HJD]

Yes

sequence



PR:000037456

profilin-2 isoform 2

PFN2/iso:2


"A profilin-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJV2-2 or a 1:1 ortholog thereof." [PMID:11034907, PRO:HJD]


organism-sequence



PR:P35080-2

profilin-2 isoform 2 (human)

hPFN2/iso:2


"A profilin-2 isoform 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35080]


organism-sequence



PR:Q9JJV2-2

profilin-2 isoform 2 (mouse)

mPFN2/iso:2


"A profilin-2 isoform 2 that is encoded in the genome of mouse." [PMID:11034907, PRO:HJD]


modification



PR:000020938

profilin-2, initiator methionine removed form

PFN2/InitMet-


"A profilin-2 that has had the initiator methionine removed." [PRO:DNx]


gene



PR:000012587

profilin-3

PFN3


"A profilin that is a translation product of the human PFN3 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:M0RCP6

profilin-3 (rat)

rPFN3


"A profilin-3 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:P60673

profilin-3 (human)

hPFN3


"A profilin-3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P60673]


organism-sequence



PR:P60673-1

profilin-3 isoform 1 (human)

hPFN3/iso:1


"A profilin-3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-gene



PR:Q9DAD6

profilin-3 (mouse)

mPFN3


"A profilin-3 that is encoded in the genome of mouse." [OMA:Q9DAD6, PRO:DNx]


organism-sequence



PR:Q9DAD6-1

profilin-3 isoform 1 (mouse)

mPFN3/iso:1


"A profilin-3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000039893

profilin-3 isoform 1

PFN3/iso:1


"A profilin-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P60673-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P60673-1

profilin-3 isoform 1 (human)

hPFN3/iso:1


"A profilin-3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9DAD6-1

profilin-3 isoform 1 (mouse)

mPFN3/iso:1


"A profilin-3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000012588

profilin-4

PFN4


"A profilin that is a translation product of the human PFN4 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P07274

profilin (yeast)

yPFN4


"A profilin-4 that is encoded in the genome of yeast." [OMA:P07274, PRO:DNx]


organism-gene



PR:P39825

profilin (Schizosaccharomyces pombe 972h-)

Spom972h-PFN4


"A profilin-4 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:P39825, PRO:DNx]


organism-gene



PR:Q5IRJ7

profilin-4 (rat)

rPFN4


"A profilin-4 that is encoded in the genome of rat." [OMA:Q5IRJ7, PRO:DNx]


organism-sequence



PR:Q5IRJ7-1

profilin-4 isoform 1 (rat)

rPFN4/iso:1


"A profilin-4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q8NHR9

profilin-4 (human)

hPFN4


"A profilin-4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8NHR9]


organism-sequence



PR:Q8NHR9-1

profilin-4 isoform 1 (human)

hPFN4/iso:1


"A profilin-4 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-gene



PR:Q8T8M2

profilin-3 (Dictyostelium discoideum)

Dicty-profilin3


"A profilin-4 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q8T8M2, PRO:DNx]


organism-gene



PR:Q9D6I3

profilin-4 (mouse)

mPFN4


"A profilin-4 that is encoded in the genome of mouse." [OMA:Q9D6I3, PRO:DNx]


organism-sequence



PR:Q9D6I3-1

profilin-4 isoform 1 (mouse)

mPFN4/iso:1


"A profilin-4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000041987

profilin-4 isoform 1

PFN4/iso:1


"A profilin-4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NHR9-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q5IRJ7-1

profilin-4 isoform 1 (rat)

rPFN4/iso:1


"A profilin-4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q8NHR9-1

profilin-4 isoform 1 (human)

hPFN4/iso:1


"A profilin-4 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9D6I3-1

profilin-4 isoform 1 (mouse)

mPFN4/iso:1


"A profilin-4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P07737-1 hPFN1/iso:1 located_inCHEBI:59163 biomarker PMID:18829504
PR:Q9JJV2-1 mPFN2/iso:1 acts_upstream_of_or_withinGO:0030837 negative regulation of actin filament polymerization MGI_ref:4844066; PMID:18001770
located_inGO:0043195 terminal bouton MGI_ref:3714870; PMID:17541406