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Protein Ontology report - immunoglobulin complex (human)
PR:000050032 - http://purl.obolibrary.org/obo/PR_000050032
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000050032   
  PRO nameimmunoglobulin complex (human) 
  Synonyms
PRO-Short-label: EXACT:hIg
  Definition"An immunoglobulin complex whose components are encoded in the genome of human." [PRO:DAN] 
  PRO Categoryorganism-complex 
  ParentG0019814 immunoglobulin complex
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Complex0                                                  Organism-Complex 28                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
organism-complex



PR:000050032

immunoglobulin complex (human)

hIg


"An immunoglobulin complex whose components are encoded in the genome of human." [PRO:DAN]


Yes
organism-complex



PR:000050157

IgA1 immunoglobulin complex (human)

hIgA1


"An IgA immunoglobulin complex in human that is composed of (in monomeric form) two identical immunoglobulin heavy chains of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda) held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA1 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


organism-complex



PR:000050158

IgA2 immunoglobulin complex (human)

hIgA2


"An IgA immunoglobulin complex in human that is composed of (in monomeric form) two identical immunoglobulin heavy chains of the IgA2 isotype and two identical immunoglobulin light chains (kappa or lambda) held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA2 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


organism-complex



PR:000050159

IgA1 immunoglobulin complex, circulating (human)

hIgA1/circulating


"An IgA immunoglobulin complex, circulating in human that is composed of (in monomeric form) two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


organism-complex



PR:000050163

monomeric IgA1 immunoglobulin complex (human)

h(IgA1)monomeric


"An IgA1 immunoglobulin complex, circulating (human) that is composed of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


Yes
organism-complex



PR:000050165

polymeric IgA1 immunoglobulin complex (human)

h(IgA1)polymeric


"An IgA1 immunoglobulin complex, circulating (human) that is composed of two, three, or four monomeric IgA1 immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


organism-complex



PR:000050166

dimeric IgA1 immunoglobulin complex (human)

h(IgA1)dimeric


"A polymeric IgA1 immunoglobulin complex (human) that is composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA1 monomer consists of two identical immunoglobulin heavy chains of the secretory isoform of the IgA isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. Dimeric IgA1 is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


organism-complex



PR:000050167

secretory polymeric IgA1 immunoglobulin complex (human)

h(IgA1/secretory)polymeric


"A polymeric IgA1 immunoglobulin complex (human) that is complexed with one chain of secretory component (SC). Polymeric IgA1 is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


organism-complex



PR:000050168

secretory dimeric IgA1 immunoglobulin complex (human)

h(IgA1/secretory)dimeric


"A polymeric IgA1 immunoglobulin complex (human) that is a dimer of secretory IgA1 immunoglobulin complex." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


organism-complex



PR:000050160

IgA2 immunoglobulin complex, circulating (human)

hIgA2/circulating


"An IgA immunoglobulin complex, circulating in human that is composed of two identical immunoglobulin heavy chains of the secretory isoform of the IgA2 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


organism-complex



PR:000050161

IgA1 B cell receptor complex (human)

hIgA1/B-cell-receptor


"An IgA1 immunoglobulin complex in human that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the membrane-bound isoform of the IgA1 isotype, two identical immunoglobulin light chains (kappa or lambda), and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


organism-complex



PR:000050162

IgA2 B cell receptor complex (human)

hIgA2/B-cell-receptor


"An IgA2 immunoglobulin complex in human that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the membrane-bound isoform of the IgA2 isotype, two identical immunoglobulin light chains (kappa or lambda), and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16362985, PRO:ADD]


organism-complex



PR:000050170

IgD immunoglobulin complex (human)

hIgD


"An IgD immunoglobulin complex whose components are encoded in the genome of human. IgD is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392, PRO:ADD]


organism-complex



PR:000050171

IgD immunoglobulin complex, circulating (human)

hIgD/circulating


"An IgD immunoglobulin complex, circulating whose components are encoded in the genome of human. Circulating IgD is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392, PRO:ADD]


organism-complex



PR:000050172

IgD B cell receptor complex (human)

hIgD/B-cell-receptor


"An IgD B cell receptor complex whose components are encoded in the genome of human. The IgD B cell receptor complex is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains (kappa or lambda) and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:11282392, PRO:ADD]


organism-complex



PR:000050173

IgD immunoglobulin complex, GPI-anchored (human)

hIgD/anchored


"An IgD immunoglobulin complex, GPI-anchored whose components are encoded in the genome of human. GPI-anchored IgD is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells." [GOC:add, ISBN:0781765196, PMID:11282392, PMID:20727035, PRO:ADD]


organism-complex



PR:000050305

IgG1 immunoglobulin complex (human)

hIgG1


"An IgG immunoglobulin complex in human that is composed of two identical immunoglobulin heavy chains of an IgG1 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG1 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, PMID:25368619, PRO:ADD]


organism-complex



PR:000050309

IgG1 immunoglobulin complex, circulating (human)

hIgG1/circulating


"An IgG1 immunoglobulin complex (human) that is composed of two identical immunoglobulin heavy chains of an IgG1 isotype of the secretory isoform and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, PMID:25368619, PRO:ADD]


organism-complex



PR:000050313

IgG1 B cell receptor complex (human)

hIgG1/B-cell-receptor


"An IgG1 immunoglobulin complex (human) that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the membrane-bound isoform of the IgG1 isotype, two identical immunoglobulin light chains (kappa or lambda), and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:17496345, PRO:ADD]


organism-complex



PR:000050306

IgG2 immunoglobulin complex (human)

hIgG2


"An IgG immunoglobulin complex in human that is composed of two identical immunoglobulin heavy chains of an IgG2 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG2 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, PMID:25368619, PRO:ADD]


organism-complex



PR:000050310

IgG2 immunoglobulin complex, circulating (human)

hIgG2/circulating


"An IgG2 immunoglobulin complex (human) that is composed of two identical immunoglobulin heavy chains of an IgG2 isotype of the secretory isoform and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, PMID:25368619, PRO:ADD]


organism-complex



PR:000050314

IgG2 B cell receptor complex (human)

hIgG2/B-cell-receptor


"An IgG2 immunoglobulin complex (human) that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the membrane-bound isoform of the IgG2 isotype, two identical immunoglobulin light chains (kappa or lambda), and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:17496345, PRO:ADD]


organism-complex



PR:000050307

IgG3 immunoglobulin complex (human)

hIgG3


"An IgG immunoglobulin complex in human that is composed of two identical immunoglobulin heavy chains of an IgG3 isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG3 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, PMID:25368619, PRO:ADD]


organism-complex



PR:000050311

IgG3 immunoglobulin complex, circulating (human)

hIgG3/circulating


"An IgG3 immunoglobulin complex (human) that is composed of two identical immunoglobulin heavy chains of an IgG3 isotype of the secretory isoform and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, PMID:25368619, PRO:ADD]


organism-complex



PR:000050315

IgG3 B cell receptor complex (human)

hIgG3/B-cell-receptor


"An IgG3 immunoglobulin complex (human) that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the membrane-bound isoform of the IgG3 isotype, two identical immunoglobulin light chains (kappa or lambda), and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:17496345, PRO:ADD]


organism-complex



PR:000050308

IgG4 immunoglobulin complex (human)

hIgG4


"An IgG immunoglobulin complex in human that is composed of two immunoglobulin heavy chains of an IgG4 isotype and two immunoglobulin light chains (kappa or lambda), held together by disulfide bonds. An IgG4 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Note that secreted IgG4 often undergoes half-molecule exchange (exchange of one heavy chain-light chain arm for another) to form bivalent complexes (two independent binding sites) that are functionally molevalent in most biological situations." [GOC:add, PMID:19222496, PMID:25368619, PRO:ADD]


organism-complex



PR:000050312

IgG4 immunoglobulin complex, circulating (human)

hIgG4/circulating


"An IgG4 immunoglobulin complex (human) that is composed of two immunoglobulin heavy chains of an IgG4 isotype of the secretory isoform and two immunoglobulin light chains (kappa or lambda), held together by disulfide bonds and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. Note that secreted IgG4 often undergoes half-molecule exchange (exchange of one heavy chain-light chain arm for another) to form bivalent complexes (two independent binding sites) that are functionally molevalent in most biological situations." [GOC:add, PMID:25368619, PRO:ADD]


organism-complex



PR:000050316

IgG4 B cell receptor complex (human)

hIgG4/B-cell-receptor


"An IgG4 immunoglobulin complex (human) that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the membrane-bound isoform of the IgG4 isotype, two identical immunoglobulin light chains (kappa or lambda), and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:17496345, PRO:ADD]


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hIg forms found in complexes   

hIg Component
Complexes
PR:000050032 hIg PR:000050359 macro CK type 1 (human)
PR:000050360 macro CK type 2 (human)
PR:000050163 h(IgA1)monomeric PR:000050165 polymeric IgA1 immunoglobulin complex (human)
PR:000050166 dimeric IgA1 immunoglobulin complex (human)
PR:000050167 secretory polymeric IgA1 immunoglobulin complex (human)
PR:000050168 secretory dimeric IgA1 immunoglobulin complex (human)