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Protein Ontology report - cyclin-D
PR:000050022 - http://purl.obolibrary.org/obo/PR_000050022
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000050022   
  PRO namecyclin-D 
  Synonyms
PRO-Short-label: EXACT:fam:CCND
Other: EXACT:cyclin D
RELATED:Cyl
  Definition"A cyclin-related protein that is a translation product of the human CCND1, CCND2, or CCND3 genes, or 1:1 orthologs thereof." [PRO:DAN] 
  CommentRequested by=CRAFT. 
  PRO Categoryfamily 
  ParentPR:000029191 cyclin-related protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 17                                        
         Sequence2                                                  Organism-Sequence 12                                        
         Modification1                                                  Organism-Modification 22                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000050022

cyclin-D

fam:CCND


"A cyclin-related protein that is a translation product of the human CCND1, CCND2, or CCND3 genes, or 1:1 orthologs thereof." [PRO:DAN]


gene



PR:000005121

G1/S-specific cyclin-D1

CCND1


"A cyclin-D that is a translation product of the human CCND1 gene or a 1:1 ortholog thereof." [PRO:DNx]


Yes
organism-gene



PR:P24385

G1/S-specific cyclin-D1 (human)

hCCND1


"A G1/S-specific cyclin-D1 that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:P24385-1

G1/S-specific cyclin-D1 isoform 1 (human)

hCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000027132

G1/S-specific cyclin-D1 phosphorylated 1 (human)

hCCND1/Phos:1


"A G1/S-specific cyclin-D1 phosphorylated 1 in human. UniProtKB:P24385, Thr-286, MOD:00047." [PRO:DAN, Reactome:R-HSA-75811, Reactome:R-HSA-75813]

Yes

Yes
organism-modification



PR:000037511

G1/S-specific cyclin-D1 unphosphorylated 1 (human)

hCCND1/UnPhos:1


"A G1/S-specific cyclin-D1 (human) that lacks phosphorylation at the residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Thr-286, PR:000026291." [PMID:17407548, PRO:KER]

Yes

organism-modification



PR:000037512

G1/S-specific cyclin-D1 phosphorylated and multi-ubiquitinated 1 (human)

hCCND1/PhosUbiq:1


"A G1/S-specific cyclin-D1 (human) that has been both phosphorylated at the residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385 and been multi-ubiquitinated." [PMID:17081987, PMID:17407548, PRO:KER]


organism-modification



PR:000068517

G1/S-specific cyclin-D1 deaminated 1 (human)

hCCND1/Deam:1


"A G1/S-specific cyclin-D1 (human) that has been deaminated on the residue at the position equivalent to Asn-83 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Asn-83, MOD:00684." [IEDB_epitope:1569278, PRO:DNx]


organism-modification



PR:000068576

G1/S-specific cyclin-D1 methylated 1 (human)

hCCND1/Me:1


"A G1/S-specific cyclin-D1 (human) that has been methylated on the residue at the position equivalent to Cys-189 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Cys-189, MOD:00660." [IEDB_epitope:1002026, PRO:DNx]


organism-modification



PR:000070754

G1/S-specific cyclin-D1 deaminated 2 (human)

hCCND1/Deam:2


"A G1/S-specific cyclin-D1 (human) that has been deaminated on the residue at the position equivalent to Asn-216 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Asn-216, MOD:00684." [IEDB_epitope:1582215, PRO:DNx]


organism-modification



PR:000072927

G1/S-specific cyclin-D1 cysteinylated 1 (human)

hCCND1/Cyst:1


"A G1/S-specific cyclin-D1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-8 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Cys-8, MOD:00765." [IEDB_epitope:1562781, PRO:DNx]


organism-modification



PR:000075931

G1/S-specific cyclin-D1 cysteinylated 2 (human)

hCCND1/Cyst:2


"A G1/S-specific cyclin-D1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-106 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Cys-106, MOD:00765." [IEDB_epitope:1584276, PRO:DNx]


organism-modification



PR:000076531

G1/S-specific cyclin-D1 cysteinylated 3 (human)

hCCND1/Cyst:3


"A G1/S-specific cyclin-D1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-247 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Cys-247, MOD:00765." [IEDB_epitope:1562941, PRO:DNx]


organism-modification



PR:000080333

G1/S-specific cyclin-D1 phosphorylated 2 (human)

hCCND1/Phos:2


"A G1/S-specific cyclin-D1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-97 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Ser-97, MOD:00046." [IEDB_epitope:2146501, PRO:DNx]


organism-gene



PR:P25322

G1/S-specific cyclin-D1 (mouse)

mCCND1


"A G1/S-specific cyclin-D1 that is encoded in the genome of mouse." [OMA:P25322, PRO:DNx]


organism-sequence



PR:P25322-1

G1/S-specific cyclin-D1 isoform 1 (mouse)

mCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000046156

G1/S-specific cyclin-D1 phosphorylated 1 (mouse)

mCCND1/Phos:1


"A G1/S-specific cyclin-D1 (mouse) that has been phosphorylated at Thr-286. UniProtKB:P25322, Thr-286, MOD:00047." [iPTMnet:P25322, PMID:11124803]


organism-gene



PR:P39948

G1/S-specific cyclin-D1 (rat)

rCCND1


"A G1/S-specific cyclin-D1 that is encoded in the genome of rat." [OMA:P39948, PRO:DNx]


organism-sequence



PR:P39948-1

G1/S-specific cyclin-D1 isoform 1 (rat)

rCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:P55169

G1/S-specific cyclin-D1 (chicken)

chick-CCND1


"A G1/S-specific cyclin-D1 that is encoded in the genome of chicken." [OMA:P55169, PRO:DNx]


organism-gene



PR:Q90459

G1/S-specific cyclin-D1 (zebrafish)

z-CCND1


"A G1/S-specific cyclin-D1 that is encoded in the genome of zebrafish." [OMA:Q90459, PRO:DNx]


sequence



PR:000039111

G1/S-specific cyclin-D1 isoform 1

CCND1/iso:1


"A G1/S-specific cyclin-D1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24385-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P24385-1

G1/S-specific cyclin-D1 isoform 1 (human)

hCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P25322-1

G1/S-specific cyclin-D1 isoform 1 (mouse)

mCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P39948-1

G1/S-specific cyclin-D1 isoform 1 (rat)

rCCND1/iso:1


"A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


modification



PR:000027131

G1/S-specific cyclin-D1 phosphorylated 1

CCND1/Phos:1


"A G1/S-specific cyclin-D1 that includes phosphorylation at a threonine residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385. Example: UniProtKB:P24385, Thr-286, MOD:00047." [PRO:DAN, Reactome:R-HSA-75811, Reactome:R-HSA-75813]


Yes
organism-modification



PR:000027132

G1/S-specific cyclin-D1 phosphorylated 1 (human)

hCCND1/Phos:1


"A G1/S-specific cyclin-D1 phosphorylated 1 in human. UniProtKB:P24385, Thr-286, MOD:00047." [PRO:DAN, Reactome:R-HSA-75811, Reactome:R-HSA-75813]

Yes

Yes
gene



PR:000005122

G1/S-specific cyclin-D2

CCND2


"A cyclin-D that is a translation product of the human CCND2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P30279

G1/S-specific cyclin-D2 (human)

hCCND2


"A G1/S-specific cyclin-D2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P30279]


organism-sequence



PR:P30279-1

G1/S-specific cyclin-D2 isoform h1 (human)

hCCND2/iso:h1


"A G1/S-specific cyclin-D2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30279-1." [PRO:DNx, UniProtKB:P30279]


organism-sequence



PR:P30279-2

G1/S-specific cyclin-D2 isoform h2 (human)

hCCND2/iso:h2


"A G1/S-specific cyclin-D2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30279-2." [PRO:DNx, UniProtKB:P30279]


organism-modification



PR:000067586

G1/S-specific cyclin-D2 methylated 1 (human)

hCCND2/Me:1


"A G1/S-specific cyclin-D2 (human) that has been methylated on the residue at the position equivalent to Cys-242 of the amino acid sequence represented by UniProtKB:P30279-1. Example: UniProtKB:P30279-1, Cys-242, MOD:00660." [IEDB_epitope:1022456, PRO:DNx]


organism-modification



PR:000074568

G1/S-specific cyclin-D2 cysteinylated 1 (human)

hCCND2/Cyst:1


"A G1/S-specific cyclin-D2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-188 of the amino acid sequence represented by UniProtKB:P30279-1. Example: UniProtKB:P30279-1, Cys-188, MOD:00765." [IEDB_epitope:1002023, PRO:DNx]


organism-modification



PR:000074742

G1/S-specific cyclin-D2 cysteinylated 2 (human)

hCCND2/Cyst:2


"A G1/S-specific cyclin-D2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P30279-1. Example: UniProtKB:P30279-1, Cys-41, MOD:00765." [IEDB_epitope:636622, PRO:DNx]


organism-modification



PR:000076542

G1/S-specific cyclin-D2 methylated 2 (human)

hCCND2/Me:2


"A G1/S-specific cyclin-D2 (human) that has been methylated on the residue at the position equivalent to Cys-188 of the amino acid sequence represented by UniProtKB:P30279-1. Example: UniProtKB:P30279-1, Cys-188, MOD:00660." [IEDB_epitope:1000198, IEDB_epitope:1002024, PRO:DNx]


organism-modification



PR:000081364

G1/S-specific cyclin-D2 methylated 3 (human)

hCCND2/Me:3


"A G1/S-specific cyclin-D2 (human) that has been methylated on the residue at the position equivalent to Met-196 of the amino acid sequence represented by UniProtKB:P30279-1. Example: UniProtKB:P30279-1, Met-196, MOD:00716." [IEDB_epitope:429335, PRO:DNx]


organism-modification



PR:000083022

G1/S-specific cyclin-D2 methylated 4 (human)

hCCND2/Me:4


"A G1/S-specific cyclin-D2 (human) that has been methylated on the residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P30279-1. Example: UniProtKB:P30279-1, Cys-41, MOD:00660." [IEDB_epitope:1047150, PRO:DNx]


organism-modification



PR:000085089

G1/S-specific cyclin-D2 cysteinylated 3 (human)

hCCND2/Cyst:3


"A G1/S-specific cyclin-D2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-105 of the amino acid sequence represented by UniProtKB:P30279-1. Example: UniProtKB:P30279-1, Cys-105, MOD:00765." [IEDB_epitope:1859185, PRO:DNx]


organism-gene



PR:P30280

G1/S-specific cyclin-D2 (mouse)

mCCND2


"A G1/S-specific cyclin-D2 that is encoded in the genome of mouse." [OMA:P30280, PRO:DNx]


organism-gene



PR:P42753

cyclin-D3-1 (Arabidopsis thaliana)

At-CCND2


"A G1/S-specific cyclin-D2 that is encoded in the genome of Arabidopsis thaliana." [PRO:DNx]


organism-gene



PR:P49706

G1/S-specific cyclin-D2 (chicken)

chick-CCND2


"A G1/S-specific cyclin-D2 that is encoded in the genome of chicken." [OMA:P49706, PRO:DNx]


organism-gene



PR:Q04827

G1/S-specific cyclin-D2 (rat)

rCCND2


"A G1/S-specific cyclin-D2 that is encoded in the genome of rat." [OMA:Q04827, PRO:DNx]


gene



PR:000005123

G1/S-specific cyclin-D3

CCND3


"A cyclin-D that is a translation product of the human CCND3 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P30281

G1/S-specific cyclin-D3 (human)

hCCND3


"A G1/S-specific cyclin-D3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P30281]


organism-sequence



PR:P30281-1

G1/S-specific cyclin-D3 isoform 1 (human)

hCCND3/iso:1


"A G1/S-specific cyclin-D3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P30281-2

G1/S-specific cyclin-D3 isoform h2 (human)

hCCND3/iso:h2


"A G1/S-specific cyclin-D3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30281-2." [PRO:DNx, UniProtKB:P30281]


organism-sequence



PR:P30281-3

G1/S-specific cyclin-D3 isoform h3 (human)

hCCND3/iso:h3


"A G1/S-specific cyclin-D3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30281-3." [PRO:DNx, UniProtKB:P30281]


organism-sequence



PR:P30281-4

G1/S-specific cyclin-D3 isoform h4 (human)

hCCND3/iso:h4


"A G1/S-specific cyclin-D3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30281-4." [PRO:DNx, UniProtKB:P30281]


organism-modification



PR:000045742

G1/S-specific cyclin-D3 phosphorylated 1 (human)

hCCND3/Phos:1


"A G1/S-specific cyclin-D3 (human) that has been phosphorylated on the residue at the position equivalent to Thr-283 of the amino acid sequence represented by UniProtKB:P30281-1. Example: UniProtKB:P30281-1, Thr-283, MOD:00047." [iPTMnet:P30281, PMID:15252116, PMID:15326477]


organism-modification



PR:000067705

G1/S-specific cyclin-D3 methylated 1 (human)

hCCND3/Me:1


"A G1/S-specific cyclin-D3 (human) that has been methylated on the residue at the position equivalent to Cys-189 of the amino acid sequence represented by UniProtKB:P30281-1. Example: UniProtKB:P30281-1, Cys-189, MOD:00660." [IEDB_epitope:1000199, PRO:DNx]


organism-modification



PR:000069186

G1/S-specific cyclin-D3 cysteinylated 1 (human)

hCCND3/Cyst:1


"A G1/S-specific cyclin-D3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-91 of the amino acid sequence represented by UniProtKB:P30281-1. Example: UniProtKB:P30281-1, Cys-91, MOD:00765." [IEDB_epitope:933023, PRO:DNx]


organism-modification



PR:000074033

G1/S-specific cyclin-D3 cysteinylated 2 (human)

hCCND3/Cyst:2


"A G1/S-specific cyclin-D3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-73 of the amino acid sequence represented by UniProtKB:P30281-1. Example: UniProtKB:P30281-1, Cys-73, MOD:00765." [IEDB_epitope:1568840, PRO:DNx]


organism-gene



PR:P30282

G1/S-specific cyclin-D3 (mouse)

mCCND3


"A G1/S-specific cyclin-D3 that is encoded in the genome of mouse." [OMA:P30282, PRO:DNx]


organism-sequence



PR:P30282-1

G1/S-specific cyclin-D3 isoform 1 (mouse)

mCCND3/iso:1


"A G1/S-specific cyclin-D3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:P42752

cyclin-D2-1 (Arabidopsis thaliana)

At-CCND3


"A G1/S-specific cyclin-D3 that is encoded in the genome of Arabidopsis thaliana." [OMA:P42752, PRO:DNx]


organism-sequence



PR:P42752-1

cyclin-D2-1 isoform 1 (Arabidopsis thaliana)

At-CCND3/iso:1


"A cyclin-D2-1 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42752-1." [PRO:DNx, UniProtKB:P42752]


organism-gene



PR:P48961

G1/S-specific cyclin-D3 (rat)

rCCND3


"A G1/S-specific cyclin-D3 that is encoded in the genome of rat." [OMA:P48961, PRO:DNx]


organism-gene



PR:Q9U2M5

G1/S-specific cyclin-D (worm)

CCND3 (worm)


"A G1/S-specific cyclin-D3 that is encoded in the genome of worm." [OMA:Q9U2M5, PRO:DNx]


sequence



PR:000039242

G1/S-specific cyclin-D3 isoform 1

CCND3/iso:1


"A G1/S-specific cyclin-D3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30281-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P30281-1

G1/S-specific cyclin-D3 isoform 1 (human)

hCCND3/iso:1


"A G1/S-specific cyclin-D3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P30282-1

G1/S-specific cyclin-D3 isoform 1 (mouse)

mCCND3/iso:1


"A G1/S-specific cyclin-D3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q8LGA1

cyclin-D4-1 (Arabidopsis thaliana)

At-CYCD4-1


"A cyclin-D that is a translation product of the CYCD4-1 gene in Arabidopsis thaliana." [PRO:DAN, UniProtKB:Q8LGA1]


organism-sequence



PR:Q8LGA1-1

cyclin-D4-1 isoform 1 (Arabidopsis thaliana)

At-CYCD4-1/iso:1


"A cyclin-D4-1 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8LGA1-1." [PRO:DNx, UniProtKB:Q8LGA1]


organism-gene



PR:Q9SN11

cyclin-D3-3 (Arabidopsis thaliana)

At-CYCD3-3


"A cyclin-D that is a translation product of the CYCD3-3 gene in Arabidopsis thaliana." [PRO:DAN, UniProtKB:Q9SN11]


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fam:CCND forms found in complexes   

fam:CCND Component
Complexes
PR:000005121 CCND1 PR:000026740 cyclin D1:Cdk4
PR:000027131 CCND1/Phos:1 PR:000027140 cyclin D1:Cdk4 complex phosphorylated 1
PR:000027132 hCCND1/Phos:1 PR:000027150 cyclin D1:Cdk4 complex phosphorylated 1 (human)
PR:P24385 hCCND1 PR:000026741 cyclin D1:Cdk4 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027132 hCCND1/Phos:1
UniProtKB:P24385, Thr-286, MOD:00047
enablesincreased GO:0005515 protein binding with PR:000037513 SCF(FBX4-alphaB crystallin) complex (human) PMID:17407548
PR:000037511 hCCND1/UnPhos:1
UniProtKB:P24385, Thr-286, PR:000026291
associated_with_disease_progressionDO:162 cancer PMID:17407548