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Protein Ontology report - cyclin-D
PR:000050022 - http://purl.obolibrary.org/obo/PR_000050022
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000050022   
  PRO namecyclin-D 
  Synonyms
PRO-Short-label: EXACT:fam:CCND
Other: EXACT:cyclin D
RELATED:Cyl
  Definition"A cyclin-related protein that is a translation product of the human CCND1, CCND2, or CCND3 genes, or 1:1 orthologs thereof." [PRO:DAN] 
  CommentRequested by=CRAFT. 
  PRO Categoryfamily 
  ParentPR:000029191 cyclin-related protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 17                                        
         Sequence2                                                  Organism-Sequence 12                                        
         Modification1                                                  Organism-Modification 22                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000050022 cyclin-D
fam:CCND

gene


PR:000005121 G1/S-specific cyclin-D1
CCND1

Yes
organism-gene


PR:P24385 G1/S-specific cyclin-D1 (human)
hCCND1

Yes
organism-sequence


PR:P24385-1 G1/S-specific cyclin-D1 isoform 1 (human)
hCCND1/iso:1

organism-modification


PR:000027132 G1/S-specific cyclin-D1 phosphorylated 1 (human)
hCCND1/Phos:1
Yes
Yes
organism-modification


PR:000037511 G1/S-specific cyclin-D1 unphosphorylated 1 (human)
hCCND1/UnPhos:1
Yes
organism-modification


PR:000037512 G1/S-specific cyclin-D1 phosphorylated and multi-ubiquitinated 1 (human)
hCCND1/PhosUbiq:1

organism-modification


PR:000068517 G1/S-specific cyclin-D1 deaminated 1 (human)
hCCND1/Deam:1

organism-modification


PR:000068576 G1/S-specific cyclin-D1 methylated 1 (human)
hCCND1/Me:1

organism-modification


PR:000070754 G1/S-specific cyclin-D1 deaminated 2 (human)
hCCND1/Deam:2

organism-modification


PR:000072927 G1/S-specific cyclin-D1 cysteinylated 1 (human)
hCCND1/Cyst:1

organism-modification


PR:000075931 G1/S-specific cyclin-D1 cysteinylated 2 (human)
hCCND1/Cyst:2

organism-modification


PR:000076531 G1/S-specific cyclin-D1 cysteinylated 3 (human)
hCCND1/Cyst:3

organism-modification


PR:000080333 G1/S-specific cyclin-D1 phosphorylated 2 (human)
hCCND1/Phos:2

organism-gene


PR:P25322 G1/S-specific cyclin-D1 (mouse)
mCCND1

organism-sequence


PR:P25322-1 G1/S-specific cyclin-D1 isoform 1 (mouse)
mCCND1/iso:1

organism-modification


PR:000046156 G1/S-specific cyclin-D1 phosphorylated 1 (mouse)
mCCND1/Phos:1

organism-gene


PR:P39948 G1/S-specific cyclin-D1 (rat)
rCCND1

organism-sequence


PR:P39948-1 G1/S-specific cyclin-D1 isoform 1 (rat)
rCCND1/iso:1

organism-gene


PR:P55169 G1/S-specific cyclin-D1 (chicken)
chick-CCND1

organism-gene


PR:Q90459 G1/S-specific cyclin-D1 (zebrafish)
z-CCND1

sequence


PR:000039111 G1/S-specific cyclin-D1 isoform 1
CCND1/iso:1

organism-sequence


PR:P24385-1 G1/S-specific cyclin-D1 isoform 1 (human)
hCCND1/iso:1

organism-sequence


PR:P25322-1 G1/S-specific cyclin-D1 isoform 1 (mouse)
mCCND1/iso:1

organism-sequence


PR:P39948-1 G1/S-specific cyclin-D1 isoform 1 (rat)
rCCND1/iso:1

modification


PR:000027131 G1/S-specific cyclin-D1 phosphorylated 1
CCND1/Phos:1

Yes
organism-modification


PR:000027132 G1/S-specific cyclin-D1 phosphorylated 1 (human)
hCCND1/Phos:1
Yes
Yes
gene


PR:000005122 G1/S-specific cyclin-D2
CCND2

organism-gene


PR:P30279 G1/S-specific cyclin-D2 (human)
hCCND2

organism-sequence


PR:P30279-1 G1/S-specific cyclin-D2 isoform h1 (human)
hCCND2/iso:h1

organism-sequence


PR:P30279-2 G1/S-specific cyclin-D2 isoform h2 (human)
hCCND2/iso:h2

organism-modification


PR:000067586 G1/S-specific cyclin-D2 methylated 1 (human)
hCCND2/Me:1

organism-modification


PR:000074568 G1/S-specific cyclin-D2 cysteinylated 1 (human)
hCCND2/Cyst:1

organism-modification


PR:000074742 G1/S-specific cyclin-D2 cysteinylated 2 (human)
hCCND2/Cyst:2

organism-modification


PR:000076542 G1/S-specific cyclin-D2 methylated 2 (human)
hCCND2/Me:2

organism-modification


PR:000081364 G1/S-specific cyclin-D2 methylated 3 (human)
hCCND2/Me:3

organism-modification


PR:000083022 G1/S-specific cyclin-D2 methylated 4 (human)
hCCND2/Me:4

organism-modification


PR:000085089 G1/S-specific cyclin-D2 cysteinylated 3 (human)
hCCND2/Cyst:3

organism-gene


PR:P30280 G1/S-specific cyclin-D2 (mouse)
mCCND2

organism-gene


PR:P42753 cyclin-D3-1 (Arabidopsis thaliana)
At-CCND2

organism-gene


PR:P49706 G1/S-specific cyclin-D2 (chicken)
chick-CCND2

organism-gene


PR:Q04827 G1/S-specific cyclin-D2 (rat)
rCCND2

gene


PR:000005123 G1/S-specific cyclin-D3
CCND3

organism-gene


PR:P30281 G1/S-specific cyclin-D3 (human)
hCCND3

organism-sequence


PR:P30281-1 G1/S-specific cyclin-D3 isoform 1 (human)
hCCND3/iso:1

organism-sequence


PR:P30281-2 G1/S-specific cyclin-D3 isoform h2 (human)
hCCND3/iso:h2

organism-sequence


PR:P30281-3 G1/S-specific cyclin-D3 isoform h3 (human)
hCCND3/iso:h3

organism-sequence


PR:P30281-4 G1/S-specific cyclin-D3 isoform h4 (human)
hCCND3/iso:h4

organism-modification


PR:000045742 G1/S-specific cyclin-D3 phosphorylated 1 (human)
hCCND3/Phos:1

organism-modification


PR:000067705 G1/S-specific cyclin-D3 methylated 1 (human)
hCCND3/Me:1

organism-modification


PR:000069186 G1/S-specific cyclin-D3 cysteinylated 1 (human)
hCCND3/Cyst:1

organism-modification


PR:000074033 G1/S-specific cyclin-D3 cysteinylated 2 (human)
hCCND3/Cyst:2

organism-gene


PR:P30282 G1/S-specific cyclin-D3 (mouse)
mCCND3

organism-sequence


PR:P30282-1 G1/S-specific cyclin-D3 isoform 1 (mouse)
mCCND3/iso:1

organism-gene


PR:P42752 cyclin-D2-1 (Arabidopsis thaliana)
At-CCND3

organism-sequence


PR:P42752-1 cyclin-D2-1 isoform 1 (Arabidopsis thaliana)
At-CCND3/iso:1

organism-gene


PR:P48961 G1/S-specific cyclin-D3 (rat)
rCCND3

organism-gene


PR:Q9U2M5 G1/S-specific cyclin-D (worm)
CCND3 (worm)

sequence


PR:000039242 G1/S-specific cyclin-D3 isoform 1
CCND3/iso:1

organism-sequence


PR:P30281-1 G1/S-specific cyclin-D3 isoform 1 (human)
hCCND3/iso:1

organism-sequence


PR:P30282-1 G1/S-specific cyclin-D3 isoform 1 (mouse)
mCCND3/iso:1

organism-gene


PR:Q8LGA1 cyclin-D4-1 (Arabidopsis thaliana)
At-CYCD4-1

organism-sequence


PR:Q8LGA1-1 cyclin-D4-1 isoform 1 (Arabidopsis thaliana)
At-CYCD4-1/iso:1

organism-gene


PR:Q9SN11 cyclin-D3-3 (Arabidopsis thaliana)
At-CYCD3-3

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fam:CCND forms found in complexes   

fam:CCND Component
 Complexes
PR:000005121 CCND1 PR:000026740 cyclin D1:Cdk4
PR:000027131 CCND1/Phos:1 PR:000027140 cyclin D1:Cdk4 complex phosphorylated 1
PR:000027132 hCCND1/Phos:1 PR:000027150 cyclin D1:Cdk4 complex phosphorylated 1 (human)
PR:P24385 hCCND1 PR:000026741 cyclin D1:Cdk4 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027132 hCCND1/Phos:1
UniProtKB:P24385, Thr-286, MOD:00047		 enablesincreased GO:0005515 protein binding with PR:000037513 SCF(FBX4-alphaB crystallin) complex (human) PMID:17407548
PR:000037511 hCCND1/UnPhos:1
UniProtKB:P24385, Thr-286, PR:000026291		 associated_with_disease_progressionDO:162 cancer PMID:17407548