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Protein Ontology report - TGF-beta receptor type-1, signal peptide removed form (human)
PR:000049432 - http://purl.obolibrary.org/obo/PR_000049432
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000049432   
  PRO nameTGF-beta receptor type-1, signal peptide removed form (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFBR1/SigPep-
PRO-proteoform-std: EXACT:UniProtKB:P36897, 34-503
PRO-proteoform-ftid: EXACT:PRO_0000024423
  Definition"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839] 
  PRO Categoryorganism-modification 
  ParentPR:000025932 TGF-beta receptor type-1, signal peptide removed form
PR:P36897 TGF-beta receptor type-1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification0                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-modification


PR:000049432
TGF-beta receptor type-1, signal peptide removed form (human)
hTGFBR1/SigPep-
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]

organism-modification


PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification


PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification


PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]

organism-modification


PR:000060809
TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)
hTGFBR1/var:G52R/SigPep-
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Gly-52 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Gly-52, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3656368]

organism-modification


PR:000060890
TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:R414*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Arg-413 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-413, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656508]

organism-modification


PR:000061254
TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)
hTGFBR1/var:P83L/SigPep-
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3656341]

organism-modification


PR:000061891
TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)
hTGFBR1/var:P83S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656326]

organism-modification


PR:000063489
TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)
hTGFBR1/var:C41Y/SigPep-
"A TGF-beta receptor type-1 (human) that has a Tyr residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Cys-41, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3656328]

organism-modification


PR:000063569
TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)
hTGFBR1/var:N45S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Asn-45 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Asn-45, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656348]

organism-modification


PR:000064307
TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:W242*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-241, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656504]

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hTGFBR1/SigPep- forms found in complexes   

hTGFBR1/SigPep- Component
 Complexes
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PR:000025961 transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1
UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:7774578
GO:0007165 signal transduction PMID:8242743
GO:0007181 transforming growth factor beta receptor complex assembly PMID:8947046
enablesGO:0005025 transforming growth factor beta receptor activity, type I PMID:7774578; PMID:8947046
located_inGO:0005886 plasma membrane PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep-
UniProtKB:P36897-1, 34-503		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8242743
GO:0007181 transforming growth factor beta receptor complex assembly PMID:8242743
located_inGO:0005886 plasma membrane PMID:8242743