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Protein Ontology report - corticotropin-releasing factor receptor
PR:000044630 - http://purl.obolibrary.org/obo/PR_000044630
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000044630   
  PRO namecorticotropin-releasing factor receptor 
  Definition"A secretin-like G-protein coupled receptor that is a translation product of the human CRHR1 or CRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ] 
  PRO Categoryfamily 
  ParentPR:000001095 secretin-like G-protein coupled receptor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 7                                        
         Sequence5                                                  Organism-Sequence 19                                        
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARfam:19
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000044630

corticotropin-releasing factor receptor

fam:vgate_ion_chan


"A secretin-like G-protein coupled receptor that is a translation product of the human CRHR1 or CRHR2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:XQ]


gene



PR:000005869

corticotropin-releasing factor receptor 1

CRHR1


"A corticotropin-releasing factor receptor that is a translation product of the human CRHR1 gene or a 1:1 ortholog thereof." [PRO:DAN]


organism-gene



PR:P34998

corticotropin-releasing factor receptor 1 (human)

hCRHR1


"A corticotropin-releasing factor receptor 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P34998]


organism-sequence



PR:P34998-1

corticotropin-releasing factor receptor 1 isoform hCRF-R1 (human)

hCRHR1/iso:hCRF-R1


"A corticotropin-releasing factor receptor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34998-1." [PRO:DNx, UniProtKB:P34998]


organism-sequence



PR:P34998-2

corticotropin-releasing factor receptor 1 isoform CRF-R2 (human)

hCRHR1/iso:CRF-R2


"A corticotropin-releasing factor receptor 1 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P34998-3

corticotropin-releasing factor receptor 1 isoform hCRF-R3 (human)

hCRHR1/iso:hCRF-R3


"A corticotropin-releasing factor receptor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34998-3." [PRO:DNx, UniProtKB:P34998]


organism-sequence



PR:P34998-4

corticotropin-releasing factor receptor 1 isoform hCRF-R4 (human)

hCRHR1/iso:hCRF-R4


"A corticotropin-releasing factor receptor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34998-4." [PRO:DNx, UniProtKB:P34998]


organism-sequence



PR:P34998-5

corticotropin-releasing factor receptor 1 isoform h5 (human)

hCRHR1/iso:h5


"A corticotropin-releasing factor receptor 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34998-5." [PRO:DNx, UniProtKB:P34998]


organism-modification



PR:000047066

corticotropin-releasing factor receptor 1, signal peptide removed form (human)

hCRHR1/SigPep-


"A corticotropin-releasing factor receptor 1 (human) that has had the signal peptide removed. Example: UniProtKB:P34998-2, 24-415." [PRO:DNx, Reactome:R-HSA-420166]


organism-gene



PR:P35347

corticotropin-releasing factor receptor 1 (mouse)

mCRHR1


"A corticotropin-releasing factor receptor 1 that is encoded in the genome of mouse." [OMA:P35347, PRO:DNx]


organism-sequence



PR:P35347-1

corticotropin-releasing factor receptor 1 isoform 1 (mouse)

mCRHR1/iso:1


"A corticotropin-releasing factor receptor 1 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:P35353

corticotropin-releasing factor receptor 1 (rat)

rCRHR1


"A corticotropin-releasing factor receptor 1 that is encoded in the genome of rat." [OMA:P35353, PRO:DNx]


organism-sequence



PR:P35353-1

corticotropin-releasing factor receptor 1 isoform 1 (rat)

rCRHR1/iso:1


"A corticotropin-releasing factor receptor 1 isoform 2 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q90812

corticotropin-releasing factor receptor 1 (chicken)

chick-CRHR1


"A corticotropin-releasing factor receptor 1 that is encoded in the genome of chicken." [OMA:Q90812, PRO:DNx]


sequence



PR:000039322

corticotropin-releasing factor receptor 1 isoform 2

CRHR1/iso:2


"A corticotropin-releasing factor receptor 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P34998-2 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P34998-2

corticotropin-releasing factor receptor 1 isoform CRF-R2 (human)

hCRHR1/iso:CRF-R2


"A corticotropin-releasing factor receptor 1 isoform 2 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P35347-1

corticotropin-releasing factor receptor 1 isoform 1 (mouse)

mCRHR1/iso:1


"A corticotropin-releasing factor receptor 1 isoform 2 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P35353-1

corticotropin-releasing factor receptor 1 isoform 1 (rat)

rCRHR1/iso:1


"A corticotropin-releasing factor receptor 1 isoform 2 that is encoded in the genome of rat." [PRO:DNx]


modification



PR:000019487

corticotropin-releasing factor receptor 1, signal peptide removed form

CRHR1/SigPep-


"A corticotropin-releasing factor receptor 1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000047066

corticotropin-releasing factor receptor 1, signal peptide removed form (human)

hCRHR1/SigPep-


"A corticotropin-releasing factor receptor 1 (human) that has had the signal peptide removed. Example: UniProtKB:P34998-2, 24-415." [PRO:DNx, Reactome:R-HSA-420166]


gene



PR:000005870

corticotropin-releasing factor receptor 2

CRHR2


"A corticotropin-releasing factor receptor that is a translation product of the human CRHR2 gene or a 1:1 ortholog thereof." [PRO:DAN]


organism-gene



PR:P47866

corticotropin-releasing factor receptor 2 (rat)

rCRHR2


"A corticotropin-releasing factor receptor 2 that is encoded in the genome of rat." [OMA:P47866, PRO:DNx]


organism-sequence



PR:P47866-1

corticotropin-releasing factor receptor 2 isoform rCRF2-alpha (rat)

rCRHR2/iso:rCRF2-alpha


"A corticotropin-releasing factor receptor 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P47866-1." [PRO:DNx, UniProtKB:P47866]


organism-sequence



PR:P47866-2

corticotropin-releasing factor receptor 2 isoform rCRF2-beta (rat)

rCRHR2/iso:rCRF2-beta


"A corticotropin-releasing factor receptor 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P47866-2." [PRO:DNx, UniProtKB:P47866]


organism-gene



PR:Q13324

corticotropin-releasing factor receptor 2 (human)

hCRHR2


"A corticotropin-releasing factor receptor 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13324]


organism-sequence



PR:Q13324-1

corticotropin-releasing factor receptor 2 isoform alpha (human)

hCRHR2/iso:alpha


"A corticotropin-releasing factor receptor 2 isoform alpha that is encoded in the genome of human." [PMID:8536644, PRO:CNA]


organism-sequence



PR:Q13324-2

corticotropin-releasing factor receptor 2 isoform beta (human)

hCRHR2/iso:beta


"A corticotropin-releasing factor receptor 2 isoform beta that is encoded in the genome of human." [PMID:9199241, PRO:CNA]


organism-sequence



PR:Q13324-3

corticotropin-releasing factor receptor 2 isoform gamma (human)

hCRHR2/iso:gamma


"A corticotropin-releasing factor receptor 2 isoform gamma that is encoded in the genome of human." [PMID:9717834, PRO:CNA]


organism-sequence



PR:Q13324-4

corticotropin-releasing factor receptor 2 isoform D (human)

hCRHR2/iso:D


"A corticotropin-releasing factor receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13324-4." [PRO:DNx, UniProtKB:Q13324]


organism-sequence



PR:Q13324-5

corticotropin-releasing factor receptor 2 isoform E (human)

hCRHR2/iso:E


"A corticotropin-releasing factor receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13324-5." [PRO:DNx, UniProtKB:Q13324]


organism-sequence



PR:Q13324-6

corticotropin-releasing factor receptor 2 isoform F (human)

hCRHR2/iso:F


"A corticotropin-releasing factor receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13324-6." [PRO:DNx, UniProtKB:Q13324]


organism-sequence



PR:Q13324-7

corticotropin-releasing factor receptor 2 isoform desQ (human)

hCRHR2/iso:desQ


"A corticotropin-releasing factor receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13324-7." [PRO:DNx, UniProtKB:Q13324]


organism-gene



PR:Q60748

corticotropin-releasing factor receptor 2 (mouse)

mCRHR2


"A corticotropin-releasing factor receptor 2 that is encoded in the genome of mouse." [OMA:Q60748, PRO:DAN]


organism-sequence



PR:C0K3M3

corticotropin-releasing factor receptor 2 isoform iv-beta (mouse)

mCRHR2/iso:iv-beta


"A corticotropin-releasing factor receptor 2 isoform iv-beta that is encoded in the genome of mouse." [PMID:7708757, PRO:HJD]

Yes

organism-sequence



PR:Q60748-1

corticotropin-releasing factor receptor 2 isoform mCRF2-alpha (mouse)

mCRHR2/iso:mCRF2-alpha


"A corticotropin-releasing factor receptor 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60748-1." [PRO:DNx, UniProtKB:Q60748]


organism-sequence



PR:Q60748-2

corticotropin-releasing factor receptor 2 isoform beta (mouse)

mCRHR2/iso:beta


"A corticotropin-releasing factor receptor 2 isoform beta that is encoded in the genome of mouse." [PMID:7708757, PRO:HJD]

Yes

sequence



PR:000026079

corticotropin-releasing factor receptor 2 isoform alpha

CRHR2/iso:alpha


"A corticotropin-releasing factor receptor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13324-1 or a 1:1 ortholog thereof." [PMID:8536644, PRO:CNA]


organism-sequence



PR:Q13324-1

corticotropin-releasing factor receptor 2 isoform alpha (human)

hCRHR2/iso:alpha


"A corticotropin-releasing factor receptor 2 isoform alpha that is encoded in the genome of human." [PMID:8536644, PRO:CNA]


sequence



PR:000026081

corticotropin-releasing factor receptor 2 isoform beta

CRHR2/iso:beta


"A corticotropin-releasing factor receptor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13324-2 or a 1:1 ortholog thereof." [PMID:9199241, PRO:CNA]


organism-sequence



PR:Q13324-2

corticotropin-releasing factor receptor 2 isoform beta (human)

hCRHR2/iso:beta


"A corticotropin-releasing factor receptor 2 isoform beta that is encoded in the genome of human." [PMID:9199241, PRO:CNA]


organism-sequence



PR:Q60748-2

corticotropin-releasing factor receptor 2 isoform beta (mouse)

mCRHR2/iso:beta


"A corticotropin-releasing factor receptor 2 isoform beta that is encoded in the genome of mouse." [PMID:7708757, PRO:HJD]

Yes

sequence



PR:000026083

corticotropin-releasing factor receptor 2 isoform gamma

CRHR2/iso:gamma


"A corticotropin-releasing factor receptor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13324-3 or a 1:1 ortholog thereof." [PMID:9717834, PRO:CNA]


organism-sequence



PR:Q13324-3

corticotropin-releasing factor receptor 2 isoform gamma (human)

hCRHR2/iso:gamma


"A corticotropin-releasing factor receptor 2 isoform gamma that is encoded in the genome of human." [PMID:9717834, PRO:CNA]


sequence



PR:000026086

corticotropin-releasing factor receptor 2 isoform iv-beta

CRHR2/iso:iv-beta


"A corticotropin-releasing factor receptor 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:C0K3M3 or a 1:1 ortholog thereof. This sequence corresponds to the isoform beta with an insertion that encodes to includes a unique C-terminal cytoplasmic tail." [PRO:HJD]


organism-sequence



PR:C0K3M3

corticotropin-releasing factor receptor 2 isoform iv-beta (mouse)

mCRHR2/iso:iv-beta


"A corticotropin-releasing factor receptor 2 isoform iv-beta that is encoded in the genome of mouse." [PMID:7708757, PRO:HJD]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:C0K3M3 mCRHR2/iso:iv-beta acts_upstream_of_or_withinGO:0043950 positive regulation of cAMP-mediated signaling MGI_ref:3850921; PMID:19246489
GO:0043951 negative regulation of cAMP-mediated signaling MGI_ref:3850921; PMID:19246489
located_inGO:0005783 endoplasmic reticulum MGI_ref:3850921; PMID:19246489
GO:0005794 Golgi apparatus MGI_ref:3850921; PMID:19246489
NOT GO:0009986 cell surface MGI_ref:3850921; PMID:19246489
PR:Q60748-2 mCRHR2/iso:beta acts_upstream_of_or_withinGO:0043950 positive regulation of cAMP-mediated signaling PMID:19246489
located_inGO:0009986 cell surface MGI_ref:3850921; PMID:19246489