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Protein Ontology report - TIRAP:PIP2:BTK:activated TLR4 complex
PR:000037472 - http://purl.obolibrary.org/obo/PR_000037472
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000037472   
  PRO nameTIRAP:PIP2:BTK:activated TLR4 complex 
  Synonyms
Other: EXACT:MAL:PI(4,5)P2:BTK:activated TLR4
  Definition"A receptor complex that is composed of PI(4,5)P2, TIRAP/MAL, and BTK, bound to activated TLR4 complex." [PMID:11544529, PMID:12724322, PMID:12888566, Reactome:R-HSA-2201331] 
  PRO Categorycomplex 
  ParentG0043235 receptor complex
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Complex1                                                  Organism-Complex 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
complex


PR:000037472
TIRAP:PIP2:BTK:activated TLR4 complex
mCD14/Clv:2/anchored
"A receptor complex that is composed of PI(4,5)P2, TIRAP/MAL, and BTK, bound to activated TLR4 complex." [PMID:11544529, PMID:12724322, PMID:12888566, Reactome:R-HSA-2201331]

organism-complex


PR:000037447
TIRAP:PIP2:BTK:activated TLR4 complex (human)
FGF14/iso:3
"A TIRAP:PIP2:BTK:activated TLR4 complex in human that is composed of PI(4,5)P2, tyrosine unphosphorylated TIRAP/MAL, BTK, TLR4, MD2, CD14, LPS." [PMID:11544529, PMID:12724322, PMID:12888566, Reactome:R-HSA-2201331]
Yes
organism-complex


PR:000037448
pTIRAP:PIP2:BTK:activated TLR4 complex (human)
FGF14/iso:3
"A TIRAP:PIP2:BTK:activated TLR4 complex in human that is composed of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, CD14, LPS. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex." [PMID:12888566, Reactome:R-HSA-2201325]
Yes
organism-complex


PR:000037477
TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
m(LPSR:3)
"A TIRAP:PIP2:BTK:activated TLR4 complex in mouse that is composed of PI(4,5)P2, tyrosine unphosphorylated TIRAP/MAL, BTK, TLR4, MD2, and LPS." [TLR:AMM]

organism-complex


PR:000037478
pTIRAP:PIP2:BTK:activated TLR4 complex (mouse)
m(LPSR:3)
"A TIRAP:PIP2:BTK:activated TLR4 complex in mouse that is composed of PI(4,5)P2, tyrosine phosphorylated TIRAP/MAL, BTK, TLR4, MD2, and LPS. TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex." [TLR:AMM]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037447 FGF14/iso:3 acts_upstream_of_or_withinGO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_120882
GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_120882
enablesGO:0004713 protein tyrosine kinase activity Reactome:REACT_120882
located_inGO:0005886 plasma membrane Reactome:REACT_120882
PR:000037448 FGF14/iso:3
TIRAP/MAL undergoes tyrosine phosphorylation mediated by Bruton's tyrosine kinase (BTK) within the complex		 acts_upstream_of_or_withinGO:0002755 MyD88-dependent toll-like receptor signaling pathway Reactome:REACT_125282
GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_125282
located_inGO:0005886 plasma membrane Reactome:REACT_125282