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Protein Ontology report - neddylated protein
PR:000037079 - http://purl.obolibrary.org/obo/PR_000037079
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000037079   
  PRO nameneddylated protein 
  Synonyms
PRO-Short-label: EXACT:Prot/NeddLys+
  Definition"A protein that includes at least one neddylated lysine." [PRO:DAN] 
  PRO Categorymodification 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification4                                                  Organism-Modification 12                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
modification



PR:000037079

neddylated protein

Prot/NeddLys+


"A protein that includes at least one neddylated lysine." [PRO:DAN]


modification



PR:000000427

fungal/metazoan cullin-1 isoform 1 neddylated form

CUL1/iso:1/NeddLys+


"A fungal/metazoan cullin-1 isoform 1 that includes at least one neddylated lysine." [PRO:CNA]


modification



PR:000000542

fungal/metazoan cullin-1 isoform 1 neddylated 1

CUL1/iso:1/Nedd:1


"A fungal/metazoan cullin-1 isoform 1 neddylated form that has been neddylated in the conserved Lys residue within the IVR[ILV]MKxR[RK] motif. Example: UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156]


organism-modification



PR:000036454

cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1


"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]

Yes

modification



PR:000027976

plant cullin-1 rubylated 1

plantCUL1/Ruby:1


"A plant cullin-1 that has been rubylated on the Lys residue within the conserved sequence VR[IV]MK to promote the activation of SCF E3 ubiquitin ligase complexes for subsequent proteasomal degradation of target proteins. Example: UniProtKB:Q94AH6, Lys-682, MOD:01150." [PMID:10611386, PRO:CNA]


organism-modification



PR:000027977

cullin-1 rubylated 1 (Arabidopsis thaliana)

At-plantCUL1/Ruby:1


"A plant cullin-1 rubylated 1 in Arabidopsis thaliana. UniProtKB:Q94AH6, Lys-682, MOD:01150." [PMID:10611386, PRO:CNA]


Yes
organism-modification



PR:000049370

stonin-1 neddylated form (human)

hSTON1/NeddLys+


"A stonin-1 (human) that includes at least one neddylated lysine. UniProtKB:Q9Y6Q2, MOD:01150." [PRO:DNx, Reactome:R-HSA-8863726]


organism-modification



PR:000049371

stonin-2 neddylated form (human)

hSTON2/NeddLys+


"A stonin-2 (human) that includes at least one neddylated lysine. UniProtKB:Q8WXE9, MOD:01150." [PRO:DNx, Reactome:R-HSA-8863733]


organism-modification



PR:000049434

TGF-beta receptor type-2, signal peptide removed neddylated 1 (human)

hTGFBR2/SigPep-/Nedd:1


"A TGF-beta receptor type-2 (human) that has had the signal peptide removed and has been post-translationally modified to include neddylated lysine at positions 556 and 567 of the amino acid sequence represented by UniProtKB:P37173. UniProtKB:P37173, 23-567, Lys-556/Lys-567, MOD:01150." [PRO:DNx, Reactome:R-HSA-4332222]


organism-modification



PR:000064654

cullin-4B neddylated 1 (human)

hCUL4B/Nedd:1


"A cullin-4B (human) that has been neddylated on the residue at the position equivalent to Lys-859 of the amino acid sequence represented by UniProtKB:Q13620-2. Example: UniProtKB:Q13620-2, Lys-859, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952522]


organism-modification



PR:000064683

cullin-9 neddylated 1 (human)

hCUL9/Nedd:1


"A cullin-9 (human) that has been neddylated on the residue at the position equivalent to Lys-1881 of the amino acid sequence represented by UniProtKB:Q8IWT3-1. Example: UniProtKB:Q8IWT3-1, Lys-1881, MOD:01150." [PRO:DNx, Reactome:R-HSA-8955921]


organism-modification



PR:000064684

cullin-3 neddylated 1 (human)

hCUL3/Nedd:1


"A cullin-3 (human) that has been neddylated on the residue at the position equivalent to Lys-712 of the amino acid sequence represented by UniProtKB:Q13618-1. Example: UniProtKB:Q13618-1, Lys-712, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952516]


organism-modification



PR:000064753

cullin-5, initiator methionine removed neddylated 1 (human)

hCUL5/InitMet-/Nedd:1


"A cullin-5 (human) that has had the initiator methionine removed and that has been neddylated on the residue at the position equivalent to Lys-724 of the amino acid sequence represented by UniProtKB:Q93034. UniProtKB:Q93034, 2-780, Lys-724, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952014]


organism-modification



PR:000064774

cullin-2 neddylated 1 (human)

hCUL2/Nedd:1


"A cullin-2 (human) that has been neddylated on the residue at the position equivalent to Lys-689 of the amino acid sequence represented by UniProtKB:Q13617-1. Example: UniProtKB:Q13617-1, Lys-689, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952511]


organism-modification



PR:000064856

cullin-4A neddylated 1 (human)

hCUL4A/Nedd:1


"A cullin-4A (human) that has been neddylated on the residue at the position equivalent to Lys-705 of the amino acid sequence represented by UniProtKB:Q13619-1. Example: UniProtKB:Q13619-1, Lys-705, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952514]


organism-modification



PR:000064861

cullin-1 neddylated 1 (human)

hCUL1/Nedd:1


"A cullin-1 (human) that has been neddylated on the residue at the position equivalent to Lys-720 of the amino acid sequence represented by UniProtKB:Q13616. UniProtKB:Q13616, Lys-720, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952519]


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Prot/NeddLys+ forms found in complexes   

Prot/NeddLys+ Component
Complexes
PR:000027977 At-plantCUL1/Ruby:1 PR:000028458 SCF(TIR1) complex (Arabidopsis thaliana)
PR:000028465 SCF(COI1) complex (Arabidopsis thaliana)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036454 hCUL1/iso:1/Nedd:1
UniProtKB:Q13616-1, Lys-720, MOD:01150
acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:8681378
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PMID:10713156; PMID:10921923
GO:0051726 regulation of cell cycle PMID:8681378
GO:0097193 intrinsic apoptotic signaling pathway PMID:8681378
located_inGO:0019005 SCF ubiquitin ligase complex PMID:10713156; PMID:10921923; PMID:17098746