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Protein Ontology report - serine/threonine-protein kinase STK11 isoform 1
PR:000036874 - http://purl.obolibrary.org/obo/PR_000036874
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036874   
  PRO nameserine/threonine-protein kinase STK11 isoform 1 
  Synonyms
PRO-Short-label: EXACT:STK11/iso:1
Other: EXACT:LKB1(L) | LKB1L
  Definition"A serine/threonine-protein kinase STK11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WTK7-1 or a 1:1 ortholog thereof." [PMID:18854309, PRO:KRC] 
  CommentAlternative splicing of the STK11 gene after exon VIII leads to a distinct C-terminal amino acid sequence. 
  PRO Categorysequence 
  ParentPR:000015740 serine/threonine-protein kinase STK11
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification3                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000036874
serine/threonine-protein kinase STK11 isoform 1
STK11/iso:1
"A serine/threonine-protein kinase STK11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WTK7-1 or a 1:1 ortholog thereof." [PMID:18854309, PRO:KRC]

organism-sequence


PR:Q15831-1
serine/threonine-protein kinase STK11 isoform 1 (human)
hSTK11/iso:1
"A serine/threonine-protein kinase STK11 isoform 1 that is encoded in the genome of human." [PMID:18854309, PRO:CNA]

organism-sequence


PR:Q9WTK7-1
serine/threonine-protein kinase STK11 isoform 1 (mouse)
mSTK11/iso:1
"A serine/threonine-protein kinase STK11 isoform 1 that is encoded in the genome of mouse. This isoform includes the sequence encoded by exon IXa. This isoform is widely expressed." [PRO:KRC]
Yes
Yes
organism-modification


PR:000036893
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse)
mSTK11/iso:1/Phos:1
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048." [PMID:18854309, PMID:20142099, PRO:KRC]
Yes
organism-modification


PR:000036995
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse)
mSTK11/iso:1/Phos:2
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048." [PMID:21487392, PRO:KRC]
Yes
organism-modification


PR:000036997
serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse)
mSTK11/iso:1/UnPhos:1
"A serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291." [PMID:18854309, PMID:20142099, PRO:KRC]
Yes
organism-modification


PR:000045394
serine/threonine-protein kinase STK11 isoform 1 farnesylated 1 (mouse)
mSTK11/iso:1/Farn:1
"A serine/threonine-protein kinase STK11 isoform 1 (mouse) that has a farnesyl moiety on a Cys residue in the most C-terminal Cys. UniProtKB:Q9WTK7-1, Cys-433, MOD:00111." [PMID:24295069, PRO:KRC]

organism-modification


PR:000045395
serine/threonine-protein kinase STK11 isoform 1 farnesylated and phosphorylated 1 (mouse)
mSTK11/iso:1/FarnPhos:1
"A serine/threonine-protein kinase STK11 isoform 1 (mouse) that is phosphorylated on Ser-431 and has a farnesyl moiety on a Cys residue in the most C-terminal Cys. UniProtKB:Q9WTK7-1, Ser-431, MOD:00046|Cys-433, MOD:00111." [PMID:24295069, PRO:KRC]

modification


PR:000036892
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1
STK11/iso:1/Phos:1
"A serine/threonine-protein kinase STK11 isoform 1 that has been phosphorylated on two Tyr residues. Example: UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048." [PMID:18854309, PMID:20142099, PRO:KRC]

organism-modification


PR:000036893
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse)
mSTK11/iso:1/Phos:1
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048." [PMID:18854309, PMID:20142099, PRO:KRC]
Yes
modification


PR:000036994
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2
STK11/iso:1/Phos:2
"A serine/threonine-protein kinase STK11 isoform 1 that has been phosphorylated on three Tyr residues. Example: UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048." [PMID:21487392, PRO:KRC]
Yes
organism-modification


PR:000036995
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse)
mSTK11/iso:1/Phos:2
"A serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048." [PMID:21487392, PRO:KRC]
Yes
modification


PR:000036996
serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1
STK11/iso:1/UnPhos:1
"A serine/threonine-protein kinase STK11 isoform 1 that lacks phosphorylation at residues equivalent to Tyr-261 and Tyr-365 of the amino acid sequence represented by UniProtKB:Q9WTK7-1. Example: UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291." [PMID:18854309, PMID:20142099, PRO:KRC]

organism-modification


PR:000036997
serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse)
mSTK11/iso:1/UnPhos:1
"A serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 in mouse. UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291." [PMID:18854309, PMID:20142099, PRO:KRC]
Yes
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STK11/iso:1 forms found in complexes   

STK11/iso:1 Component
 Complexes
PR:Q9WTK7ZDASHZ1 mSTK11/iso:1 PR:000025037 Stk11 isoform 1:Strada:Cab39 heterotrimer (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036893 mSTK11/iso:1/Phos:1
UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048		 located_inGO:0005634 nucleus MGI_ref:4439241; PMID:20142099
PR:000036994 STK11/iso:1/Phos:2
Example: UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048		 acts_upstream_of_or_withinGO:0036399 TCR signalosome assembly MGI_ref:5003385; PMID:21487392
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI_ref:5003385; PMID:21487392
located_inGO:0036398 TCR signalosome MGI_ref:5003385; PMID:21487392
PR:000036995 mSTK11/iso:1/Phos:2
UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048		 acts_upstream_of_or_withinGO:0036399 TCR signalosome assembly MGI_ref:5003385; PMID:21487392
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation MGI_ref:5003385; PMID:21487392
located_inGO:0036398 TCR signalosome MGI_ref:5003385; PMID:21487392
PR:000036997 mSTK11/iso:1/UnPhos:1
UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291		 located_inGO:0005737 cytoplasm MGI_ref:4439241; PMID:20142099
PR:Q9WTK7-1 mSTK11/iso:1
This isoform is widely expressed		 acts_upstream_of_or_withinGO:0032147 activation of protein kinase activity MGI_ref:3836081; PMID:18854309
located_inGO:0005737 cytoplasm MGI_ref:3836081; PMID:18854309
GO:0016020 membrane MGI_ref:3836081; PMID:18854309