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Documentation
Protein Ontology report - serine/threonine-protein kinase STK11 isoform 1
PR:000036874 -
http://purl.obolibrary.org/obo/PR_000036874
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000036874
PRO name
serine/threonine-protein kinase STK11 isoform 1
Synonyms
PRO-Short-label
:
EXACT:
STK11/iso:1
Other
:
EXACT:
LKB1(L) | LKB1L
Definition
"A serine/threonine-protein kinase STK11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:Q9WTK7-1
or a 1:1 ortholog thereof." [
PMID:18854309
, PRO:KRC]
Comment
Alternative splicing of the STK11 gene after exon VIII leads to a distinct C-terminal amino acid sequence.
PRO Category
sequence
Parent
PR:000015740
serine/threonine-protein kinase STK11
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
1
Organism-Sequence
2
Modification
3
Organism-Modification
5
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
Comp.
In Complex?
sequence
PR:000036874
serine/threonine-protein kinase STK11 isoform 1
STK11/iso:1
organism-sequence
PR:Q15831-1
serine/threonine-protein kinase STK11 isoform 1 (human)
hSTK11/iso:1
organism-sequence
PR:Q9WTK7-1
serine/threonine-protein kinase STK11 isoform 1 (mouse)
mSTK11/iso:1
Yes
Yes
organism-modification
PR:000036893
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse)
mSTK11/iso:1/Phos:1
Yes
organism-modification
PR:000036995
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse)
mSTK11/iso:1/Phos:2
Yes
organism-modification
PR:000036997
serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse)
mSTK11/iso:1/UnPhos:1
Yes
organism-modification
PR:000045394
serine/threonine-protein kinase STK11 isoform 1 farnesylated 1 (mouse)
mSTK11/iso:1/Farn:1
organism-modification
PR:000045395
serine/threonine-protein kinase STK11 isoform 1 farnesylated and phosphorylated 1 (mouse)
mSTK11/iso:1/FarnPhos:1
modification
PR:000036892
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1
STK11/iso:1/Phos:1
organism-modification
PR:000036893
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 1 (mouse)
mSTK11/iso:1/Phos:1
Yes
modification
PR:000036994
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2
STK11/iso:1/Phos:2
Yes
organism-modification
PR:000036995
serine/threonine-protein kinase STK11 isoform 1 phosphorylated 2 (mouse)
mSTK11/iso:1/Phos:2
Yes
modification
PR:000036996
serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1
STK11/iso:1/UnPhos:1
organism-modification
PR:000036997
serine/threonine-protein kinase STK11 isoform 1 unphosphorylated 1 (mouse)
mSTK11/iso:1/UnPhos:1
Yes
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STK11/iso:1
forms found in complexes
STK11/iso:1
Component
Complexes
PR:Q9WTK7ZDASHZ1
mSTK11/iso:1
PR:000025037
Stk11 isoform 1:Strada:Cab39 heterotrimer (mouse)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036893
mSTK11/iso:1/Phos:1
UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, MOD:00048
located_in
GO:0005634
nucleus
MGI_ref:4439241;
PMID:20142099
PR:000036994
STK11/iso:1/Phos:2
Example: UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048
acts_upstream_of_or_within
GO:0036399
TCR signalosome assembly
MGI_ref:5003385;
PMID:21487392
GO:0050731
positive regulation of peptidyl-tyrosine phosphorylation
MGI_ref:5003385;
PMID:21487392
located_in
GO:0036398
TCR signalosome
MGI_ref:5003385;
PMID:21487392
PR:000036995
mSTK11/iso:1/Phos:2
UniProtKB:Q9WTK7-1, Tyr-36/Tyr-261/Tyr-365, MOD:00048
acts_upstream_of_or_within
GO:0036399
TCR signalosome assembly
MGI_ref:5003385;
PMID:21487392
GO:0050731
positive regulation of peptidyl-tyrosine phosphorylation
MGI_ref:5003385;
PMID:21487392
located_in
GO:0036398
TCR signalosome
MGI_ref:5003385;
PMID:21487392
PR:000036997
mSTK11/iso:1/UnPhos:1
UniProtKB:Q9WTK7-1, Tyr-261/Tyr-365, PR:000026291
located_in
GO:0005737
cytoplasm
MGI_ref:4439241;
PMID:20142099
PR:Q9WTK7-1
mSTK11/iso:1
This isoform is widely expressed
acts_upstream_of_or_within
GO:0032147
activation of protein kinase activity
MGI_ref:3836081;
PMID:18854309
located_in
GO:0005737
cytoplasm
MGI_ref:3836081;
PMID:18854309
GO:0016020
membrane
MGI_ref:3836081;
PMID:18854309
