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PRO ID
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| PRO name | prM-E complex |
| Synonyms | | PRO-Short-label: | EXACT: | DENV-prME | | Other: | EXACT: | prME |
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| Definition | "A protein-containing complex that involves the initial assembly of the dengue virion as an immature particle which contains prM noncovalently associated with E in a heterodimeric complex. It contains N-linked glycosylation sites at Asn-347, Asn-433, Asn-183. UniProtKB:P29990, 115-775, Asn-183/Asn-347/Asn-433, MOD:00160." [PMID:10590151, PRO:DAN, PRO:ES] |
| Comment | Requested by=IDODEN. In the prME heterodimer, prM prevents an irreversible conformational change of E during virus secretion through acidified sorting compartments. Proteolysis of prM leads to the formation of homodimeric forms of E in virus particles before their release from the cell. [PMID:10590151, PRO:ES]. |
| PRO Category | complex |
| Parent | G0032991 protein-containing complex
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