back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - dengue virus genome polyprotein
PR:000036816 - http://purl.obolibrary.org/obo/PR_000036816
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036816   
  PRO namedengue virus genome polyprotein 
  Synonyms
PRO-Short-label: EXACT:DenV-polyprot
  Definition"A protein that is a translation product of the dengue virus serotype 2 genomic RNA or a 1:1 ortholog thereof." [PRO:ES] 
  CommentRequested by=IDODEN. The dengue virus contains a 10.7 kb single-stranded RNA genome of positive strand polarity with a type I cap at the 5' terminus. The RNA genome is translated into a large glycosylated polyprotein precursor with proteins that are arranged in the order NH2-C-prM-E-NS1-NS2A-NS2B-NS3-NS4A-NS4B-NS5-COOH. Proteolytic processing in the region of the structural proteins is mediated by a host cell signal peptidase that is located within the endoplasmic reticulum. [PMID:12297031, PRO:ES]. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 20                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification29                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000036816

dengue virus genome polyprotein

DenV-polyprot


"A protein that is a translation product of the dengue virus serotype 2 genomic RNA or a 1:1 ortholog thereof." [PRO:ES]


organism-gene



PR:P07564

genome polyprotein (Dengue virus 2 Jamaica/1409/1983)

polyprot (DEN2J)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Jamaica/1409/1983." [PRO:ES]


organism-gene



PR:P09866

genome polyprotein (Dengue virus 4 Dominica/814669/1981)

polyprot (DEN4D)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Dominica/814669/1981." [PRO:ES]


organism-gene



PR:P12823

genome polyprotein (Dengue virus 2 Puerto Rico/PR159-S1/1969)

polyprot (DEN2P)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Puerto Rico/PR159-S1/1969." [PRO:ES]


organism-gene



PR:P14337

genome polyprotein (Dengue virus 2 Thailand/0168/1979)

polyprot (DEN28)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Thailand/0168/1979." [PRO:ES]


organism-gene



PR:P14340

genome polyprotein (Dengue virus 2 Thailand/NGS-C/1944)

polyprot (DEN2N)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Thailand/NGS-C/1944." [PRO:ES]


organism-modification



PR:000044758

NS1 (Dengue virus 2 Thailand/NGS-C/1944)

NS1 (DEN2N)


"An NS1 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:DNx]

Yes

organism-modification



PR:000044759

NS2A (Dengue virus 2 Thailand/NGS-C/1944)

NS2A (DEN2N)


"An NS2A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1128-1345." [PRO:DNx]

Yes

organism-modification



PR:000044761

NS2B (Dengue virus 2 Thailand/NGS-C/1944)

NS2B (DEN2N)


"An NS2B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1346-1475." [PRO:DNx]

Yes

organism-modification



PR:000044762

NS3 (Dengue virus 2 Thailand/NGS-C/1944)

NS3 (DEN2N)


"An NS3 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1476-2093." [PRO:DNx]

Yes

organism-modification



PR:000044763

NS4A (Dengue virus 2 Thailand/NGS-C/1944)

NS4A (DEN2N)


"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]

Yes

organism-modification



PR:000044765

2K (Dengue virus 2 Thailand/NGS-C/1944)

2K (DEN2N)


"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]

Yes

organism-modification



PR:000044766

NS4B (Dengue virus 2 Thailand/NGS-C/1944)

NS4B (DEN2N)


"An NS4B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2244-2491." [PRO:DNx]

Yes

organism-modification



PR:000044768

NS5 (Dengue virus 2 Thailand/NGS-C/1944)

NS5 (DEN2N)


"An NS5 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2492-3391." [PRO:DNx]

Yes

organism-modification



PR:000044770

prM (Dengue virus 2 Thailand/NGS-C/1944)

prM (DEN2N)


"A prM in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 115-280, Asn-183, MOD:00160." [PRO:DNx]

Yes

organism-gene



PR:P17763

genome polyprotein (Dengue virus 1 Nauru/West Pac/1974)

polyprot (DEN1W)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 1 Nauru/West Pac/1974." [PRO:ES]


organism-gene



PR:P27909

genome polyprotein (Dengue virus 1 Brazil/97-11/1997)

polyprot (DEN1B)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 1 Brazil/97-11/1997." [PRO:ES]


organism-gene



PR:P27915

genome polyprotein (Dengue virus 3 Philippines/H87/1956)

polyprot (DEN3P)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Philippines/H87/1956." [PRO:ES]


organism-gene



PR:P29990

genome polyprotein (Dengue virus 2 Thailand/16681/84)

polyprot (DEN26)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Thailand/16681/84." [PRO:ES]


organism-modification



PR:000044757

M protein (Dengue virus 2 Thailand/16681/84)

M (DEN26)


"An M protein in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 206-280." [PRO:DNx]

Yes

organism-modification



PR:000044760

NS2A (Dengue virus 2 Thailand/16681/84)

NS2A (DEN26)


"An NS2A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 1128-1345." [PRO:DNx]

Yes

organism-modification



PR:000044764

NS4A (Dengue virus 2 Thailand/16681/84)

NS4A (DEN26)


"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]

Yes

organism-modification



PR:000044767

NS4B (Dengue virus 2 Thailand/16681/84)

NS4B (DEN26)


"An NS4B in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2244-2491." [PRO:DNx]

Yes

organism-modification



PR:000044769

prM (Dengue virus 2 Thailand/16681/84)

prM (DEN26)


"A prM in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 115-280, Asn-183, MOD:00160." [PRO:DNx]

Yes

organism-gene



PR:P29991

genome polyprotein (Dengue virus 2 16681-PDK53)

polyprot (DEN27)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 16681-PDK53." [PRO:ES]


organism-gene



PR:P33478

genome polyprotein (Dengue virus 1 Singapore/S275/1990)

polyprot (DEN1S)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 1 Singapore/S275/1990." [PRO:ES]


organism-gene



PR:Q2YHF0

genome polyprotein (Dengue virus 4 Thailand/0348/1991)

polyprot (DEN4T)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Thailand/0348/1991." [PRO:ES]


organism-gene



PR:Q2YHF2

genome polyprotein (Dengue virus 4 Thailand/0476/1997)

polyprot (DEN4H)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Thailand/0476/1997." [PRO:ES]


organism-gene



PR:Q58HT7

genome polyprotein (Dengue virus 4 Philippines/H241/1956)

polyprot (DEN4P)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Philippines/H241/1956." [PRO:ES]


organism-gene



PR:Q5UB51

genome polyprotein (Dengue virus 3 Singapore/8120/1995)

polyprot (DEN3I)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Singapore/8120/1995." [PRO:ES]


organism-gene



PR:Q5UCB8

genome polyprotein (Dengue virus 4 Singapore/8976/1995)

polyprot (DEN4S)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Singapore/8976/1995." [PRO:ES]


organism-gene



PR:Q6YMS3

genome polyprotein (Dengue virus 3 Martinique/1243/1999)

polyprot (DEN3M)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Martinique/1243/1999." [PRO:ES]


organism-gene



PR:Q6YMS4

genome polyprotein (Dengue virus 3 Sri Lanka/1266/2000)

polyprot (DEN3S)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Sri Lanka/1266/2000." [PRO:ES]


organism-gene



PR:Q99D35

genome polyprotein (Dengue virus 3 China/80-2/1980)

polyprot (DEN3C)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 China/80-2/1980." [PRO:ES]


organism-gene



PR:Q9WDA6

genome polyprotein (Dengue virus 2 Peru/IQT2913/1996)

polyprot (DEN2Q)


"A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Peru/IQT2913/1996." [PRO:ES]


modification



PR:000036817

dengue virus genome polyprotein, N-glycosylated form

DenV-polyprot/NGlycoAsn+


"A dengue virus genome polyprotein that has been post-translationally modified to include N-glycosylated residues at Asn-183, Asn-347, Asn-433, Asn-905, and Asn-982. Example: UniProtKB:P29990, 1-3391, Asn-183/Asn-347/Asn-433/Asn-905/Asn-982, MOD:00160." [PRO:DAN, PRO:ES]


modification



PR:000036818

dengue virus genome polyprotein proteolytic cleavage product

DenV-polyprot/ClvPrd


"A dengue virus genome polyprotein, N-glycosylated form that has been processed by proteolytic cleavage." [PRO:DAN, PRO:ES]


modification



PR:000036819

capsid protein C

DenV-C


"A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein processed at the N-terminal end of the dengue virus RNA genome." [PRO:ES]


modification



PR:000036820

pr protein

DenV-pr


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor form prM protein on the surface of immature dengue virus by host protease during virion maturation." [PMID:23559476, PRO:ES]


modification



PR:000036821

M protein

DenV-M


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor prM and localizes to the endoplasmic reticulum and forms oligomers." [PMID:22569259, PRO:ES]


organism-modification



PR:000044757

M protein (Dengue virus 2 Thailand/16681/84)

M (DEN26)


"An M protein in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 206-280." [PRO:DNx]

Yes

modification



PR:000036822

E protein

DenV-E


"A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein containing two alpha-helices (EH1 and EH2) at the C-terminus and two transmembrane domains (ET1 and ET2) of the dengue virus RNA genome. It contains two N-linked glycosylation sites, at Asn-67 and Asn-153. Example: UniProtKB:P29990, 281-775, Asn-347/Asn-433, MOD:00160." [PMID:17459925, PMID:23300717, PRO:DAN, PRO:ES]


Yes
modification



PR:000036824

NS1

DenV-NS1


"A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:ES]


Yes
modification



PR:000037000

NS1, with complex sugar attached

DenV-NS1/sugar(+)


"An NS1 that has had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES]


Yes
modification



PR:000037001

NS1, without complex sugar attached

DenV-NS1/sugar(-)


"An NS1 that has not had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES]


Yes
organism-modification



PR:000044758

NS1 (Dengue virus 2 Thailand/NGS-C/1944)

NS1 (DEN2N)


"An NS1 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:DNx]

Yes

modification



PR:000036825

NS2A

DenV-NS2A


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome and a component of the viral replication complex." [PMID:23408612, PRO:ES]


organism-modification



PR:000044759

NS2A (Dengue virus 2 Thailand/NGS-C/1944)

NS2A (DEN2N)


"An NS2A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1128-1345." [PRO:DNx]

Yes

organism-modification



PR:000044760

NS2A (Dengue virus 2 Thailand/16681/84)

NS2A (DEN26)


"An NS2A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 1128-1345." [PRO:DNx]

Yes

modification



PR:000036826

NS2A-alpha

DenV-NS2Aalpha


"A dengue virus genome polyprotein proteolytic cleavage product that consists of 188 amino acids at the N-terminal end of NS2A." [PMID:23408612, PRO:ES]


modification



PR:000036827

NS2B

DenV-NS2B


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome containing a conserved hydrophilic domain necessary for protease activity in cleavage of the dengue virus genome polyprotein, N-glycosylated form." [PMID:10744671, PRO:ES]


Yes
organism-modification



PR:000044761

NS2B (Dengue virus 2 Thailand/NGS-C/1944)

NS2B (DEN2N)


"An NS2B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1346-1475." [PRO:DNx]

Yes

modification



PR:000036828

NS3

DenV-NS3


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural, multifunctional protein encoded by the dengue virus RNA genome with a serine protease domain." [PMID:10744671, PRO:ES]


Yes
organism-modification



PR:000044762

NS3 (Dengue virus 2 Thailand/NGS-C/1944)

NS3 (DEN2N)


"An NS3 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1476-2093." [PRO:DNx]

Yes

modification



PR:000036830

NS4A

DenV-NS4A


"A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic non-structural protein encoded by the dengue virus RNA genome that associates with membranes via 4 internal hydrophobic regions which are all able to mediate membrane targeting of a cytosolic reporter protein." [PMID:17276984, PRO:ES]


organism-modification



PR:000044763

NS4A (Dengue virus 2 Thailand/NGS-C/1944)

NS4A (DEN2N)


"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]

Yes

organism-modification



PR:000044764

NS4A (Dengue virus 2 Thailand/16681/84)

NS4A (DEN26)


"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]

Yes

modification



PR:000036831

2K

DenV-2K


"A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen." [PMID:17276984, PRO:ES]


organism-modification



PR:000044765

2K (Dengue virus 2 Thailand/NGS-C/1944)

2K (DEN2N)


"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]

Yes

modification



PR:000036832

precursor of NS4B

DenV-preNS4B


"A dengue virus genome polyprotein proteolytic cleavage product that is a precursor of NS4B." [PRO:ES]


modification



PR:000036833

NS4B

DenV-NS4B


"A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic transmembrane non-structural protein encoded by the dengue virus RNA genome which is, in part, responsible for the membrane arrangements leading to the formation of the viral replication complex." [PMID:22772157, PRO:ES]


organism-modification



PR:000044766

NS4B (Dengue virus 2 Thailand/NGS-C/1944)

NS4B (DEN2N)


"An NS4B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2244-2491." [PRO:DNx]

Yes

organism-modification



PR:000044767

NS4B (Dengue virus 2 Thailand/16681/84)

NS4B (DEN26)


"An NS4B in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2244-2491." [PRO:DNx]

Yes

modification



PR:000036841

NS4AB

DenV-NS4AB


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 by the two-component proteinase NS2B-NS3 at the NS4B-NS5 sites consisting of NS4A, 2K, and NS4B." [PMID:1531368, PRO:ES]


modification



PR:000036830

NS4A

DenV-NS4A


"A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic non-structural protein encoded by the dengue virus RNA genome that associates with membranes via 4 internal hydrophobic regions which are all able to mediate membrane targeting of a cytosolic reporter protein." [PMID:17276984, PRO:ES]


organism-modification



PR:000044763

NS4A (Dengue virus 2 Thailand/NGS-C/1944)

NS4A (DEN2N)


"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]

Yes

organism-modification



PR:000044764

NS4A (Dengue virus 2 Thailand/16681/84)

NS4A (DEN26)


"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]

Yes

modification



PR:000036842

2KNS4B

DenV-2KNS4B


"A dengue virus genome polyprotein proteolytic cleavage product that assists in the processing of NS4AB consisting of 2K and NS4B." [PMID:21810535, PRO:ES]


modification



PR:000036831

2K

DenV-2K


"A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen." [PMID:17276984, PRO:ES]


organism-modification



PR:000044765

2K (Dengue virus 2 Thailand/NGS-C/1944)

2K (DEN2N)


"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]

Yes

modification



PR:000036843

NS4B-NS5

DenV-NS4B5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 at the NS4A-NS4B site consisting of NS4B and NS5, which is believed to be mediated by a host cell signal peptidase." [PMID:1531368, PRO:ES]


modification



PR:000036833

NS4B

DenV-NS4B


"A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic transmembrane non-structural protein encoded by the dengue virus RNA genome which is, in part, responsible for the membrane arrangements leading to the formation of the viral replication complex." [PMID:22772157, PRO:ES]


organism-modification



PR:000044766

NS4B (Dengue virus 2 Thailand/NGS-C/1944)

NS4B (DEN2N)


"An NS4B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2244-2491." [PRO:DNx]

Yes

organism-modification



PR:000044767

NS4B (Dengue virus 2 Thailand/16681/84)

NS4B (DEN26)


"An NS4B in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2244-2491." [PRO:DNx]

Yes

modification



PR:000036834

precursor of NS5

DenV-preNS5


"A dengue virus genome polyprotein proteolytic cleavage product that is a precursor of NS5." [PRO:ES]


modification



PR:000036835

NS5

DenV-NS5


"A dengue virus genome polyprotein proteolytic cleavage product that is a large non-structural protein encoded by the dengue virus RNA genome containing a methyltransferase (MTase) domain and an RNA dependent RNA polymerase (POL) domain that possesses a capping enzyme." [PMID:22022449, PRO:ES]


organism-modification



PR:000044768

NS5 (Dengue virus 2 Thailand/NGS-C/1944)

NS5 (DEN2N)


"An NS5 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2492-3391." [PRO:DNx]

Yes

modification



PR:000036840

NS4A-NS4B-NS5

DenV-NS4AB5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS345 by the two-component proteinase NS2B-NS3 at the NS3-NS4A site consisting of NS4A, 2K, NS4B, and NS5." [PMID:1531368, PRO:ES]


modification



PR:000036841

NS4AB

DenV-NS4AB


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 by the two-component proteinase NS2B-NS3 at the NS4B-NS5 sites consisting of NS4A, 2K, and NS4B." [PMID:1531368, PRO:ES]


modification



PR:000036830

NS4A

DenV-NS4A


"A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic non-structural protein encoded by the dengue virus RNA genome that associates with membranes via 4 internal hydrophobic regions which are all able to mediate membrane targeting of a cytosolic reporter protein." [PMID:17276984, PRO:ES]


organism-modification



PR:000044763

NS4A (Dengue virus 2 Thailand/NGS-C/1944)

NS4A (DEN2N)


"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]

Yes

organism-modification



PR:000044764

NS4A (Dengue virus 2 Thailand/16681/84)

NS4A (DEN26)


"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]

Yes

modification



PR:000036842

2KNS4B

DenV-2KNS4B


"A dengue virus genome polyprotein proteolytic cleavage product that assists in the processing of NS4AB consisting of 2K and NS4B." [PMID:21810535, PRO:ES]


modification



PR:000036831

2K

DenV-2K


"A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen." [PMID:17276984, PRO:ES]


organism-modification



PR:000044765

2K (Dengue virus 2 Thailand/NGS-C/1944)

2K (DEN2N)


"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]

Yes

modification



PR:000036843

NS4B-NS5

DenV-NS4B5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 at the NS4A-NS4B site consisting of NS4B and NS5, which is believed to be mediated by a host cell signal peptidase." [PMID:1531368, PRO:ES]


modification



PR:000036843

NS4B-NS5

DenV-NS4B5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 at the NS4A-NS4B site consisting of NS4B and NS5, which is believed to be mediated by a host cell signal peptidase." [PMID:1531368, PRO:ES]


modification



PR:000036835

NS5

DenV-NS5


"A dengue virus genome polyprotein proteolytic cleavage product that is a large non-structural protein encoded by the dengue virus RNA genome containing a methyltransferase (MTase) domain and an RNA dependent RNA polymerase (POL) domain that possesses a capping enzyme." [PMID:22022449, PRO:ES]


organism-modification



PR:000044768

NS5 (Dengue virus 2 Thailand/NGS-C/1944)

NS5 (DEN2N)


"An NS5 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2492-3391." [PRO:DNx]

Yes

modification



PR:000036836

C-prM

DenV-CprM


"A dengue virus genome polyprotein proteolytic cleavage product that is derived from dengue virus genome polyprotein, glycosylated form and that consists only of the C (capsid) protein and the prM (pre-membrane) structural proteins of the dengue virus genome polyprotein. It has a single N-linked glycosylation site at position Asn-69. Example: UniProtKB:P29990, 1-280, Asn-183, MOD:00160." [PMID:14963133, PRO:DAN, PRO:ES]


modification



PR:000036819

capsid protein C

DenV-C


"A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein processed at the N-terminal end of the dengue virus RNA genome." [PRO:ES]


modification



PR:000036837

prM

DenV-prM


"A dengue virus genome polyprotein proteolytic cleavage product that is a product of the cleavage of C-prM by host signalase. It has a single N-linked glycosylation site at position Asn-69. Example: UniProtKB:P29990, 115-280, Asn-183, MOD:00160." [PMID:14963133, PRO:DAN, PRO:ES]


Yes
modification



PR:000036820

pr protein

DenV-pr


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor form prM protein on the surface of immature dengue virus by host protease during virion maturation." [PMID:23559476, PRO:ES]


modification



PR:000036821

M protein

DenV-M


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor prM and localizes to the endoplasmic reticulum and forms oligomers." [PMID:22569259, PRO:ES]


organism-modification



PR:000044757

M protein (Dengue virus 2 Thailand/16681/84)

M (DEN26)


"An M protein in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 206-280." [PRO:DNx]

Yes

organism-modification



PR:000044769

prM (Dengue virus 2 Thailand/16681/84)

prM (DEN26)


"A prM in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 115-280, Asn-183, MOD:00160." [PRO:DNx]

Yes

organism-modification



PR:000044770

prM (Dengue virus 2 Thailand/NGS-C/1944)

prM (DEN2N)


"A prM in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 115-280, Asn-183, MOD:00160." [PRO:DNx]

Yes

modification



PR:000036837

prM

DenV-prM


"A dengue virus genome polyprotein proteolytic cleavage product that is a product of the cleavage of C-prM by host signalase. It has a single N-linked glycosylation site at position Asn-69. Example: UniProtKB:P29990, 115-280, Asn-183, MOD:00160." [PMID:14963133, PRO:DAN, PRO:ES]


Yes
modification



PR:000036820

pr protein

DenV-pr


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor form prM protein on the surface of immature dengue virus by host protease during virion maturation." [PMID:23559476, PRO:ES]


modification



PR:000036821

M protein

DenV-M


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor prM and localizes to the endoplasmic reticulum and forms oligomers." [PMID:22569259, PRO:ES]


organism-modification



PR:000044757

M protein (Dengue virus 2 Thailand/16681/84)

M (DEN26)


"An M protein in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 206-280." [PRO:DNx]

Yes

organism-modification



PR:000044769

prM (Dengue virus 2 Thailand/16681/84)

prM (DEN26)


"A prM in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 115-280, Asn-183, MOD:00160." [PRO:DNx]

Yes

organism-modification



PR:000044770

prM (Dengue virus 2 Thailand/NGS-C/1944)

prM (DEN2N)


"A prM in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 115-280, Asn-183, MOD:00160." [PRO:DNx]

Yes

modification



PR:000036838

NS12345

DenV-NS12345


"A dengue virus genome polyprotein proteolytic cleavage product that is derived from dengue virus genome polyprotein, N-glycosylated form and that contains the entire non-structural region of the dengue virus genome polyprotein only and is responsible for directing viral genomic RNA replication, including synthesizing negative- and positive-strand RNAs and forming the viral RNA cap structure. It consists of NS1, NS2A, NS3, NS4A, 2K, NS4B, and NS5." [PMID:1433530, PMID:22022449, PRO:ES]


modification



PR:000036826

NS2A-alpha

DenV-NS2Aalpha


"A dengue virus genome polyprotein proteolytic cleavage product that consists of 188 amino acids at the N-terminal end of NS2A." [PMID:23408612, PRO:ES]


modification



PR:000036827

NS2B

DenV-NS2B


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome containing a conserved hydrophilic domain necessary for protease activity in cleavage of the dengue virus genome polyprotein, N-glycosylated form." [PMID:10744671, PRO:ES]


Yes
organism-modification



PR:000044761

NS2B (Dengue virus 2 Thailand/NGS-C/1944)

NS2B (DEN2N)


"An NS2B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1346-1475." [PRO:DNx]

Yes

modification



PR:000036839

NS345

DenV-NS345


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component proteinase NS2B-NS3 at the NS2B-NS3 site consisting of NS3, NS4A, NS4B, and NS5." [PMID:1433530, PRO:ES]


modification



PR:000036828

NS3

DenV-NS3


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural, multifunctional protein encoded by the dengue virus RNA genome with a serine protease domain." [PMID:10744671, PRO:ES]


Yes
organism-modification



PR:000044762

NS3 (Dengue virus 2 Thailand/NGS-C/1944)

NS3 (DEN2N)


"An NS3 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1476-2093." [PRO:DNx]

Yes

modification



PR:000036840

NS4A-NS4B-NS5

DenV-NS4AB5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS345 by the two-component proteinase NS2B-NS3 at the NS3-NS4A site consisting of NS4A, 2K, NS4B, and NS5." [PMID:1531368, PRO:ES]


modification



PR:000036841

NS4AB

DenV-NS4AB


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 by the two-component proteinase NS2B-NS3 at the NS4B-NS5 sites consisting of NS4A, 2K, and NS4B." [PMID:1531368, PRO:ES]


modification



PR:000036830

NS4A

DenV-NS4A


"A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic non-structural protein encoded by the dengue virus RNA genome that associates with membranes via 4 internal hydrophobic regions which are all able to mediate membrane targeting of a cytosolic reporter protein." [PMID:17276984, PRO:ES]


organism-modification



PR:000044763

NS4A (Dengue virus 2 Thailand/NGS-C/1944)

NS4A (DEN2N)


"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]

Yes

organism-modification



PR:000044764

NS4A (Dengue virus 2 Thailand/16681/84)

NS4A (DEN26)


"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]

Yes

modification



PR:000036842

2KNS4B

DenV-2KNS4B


"A dengue virus genome polyprotein proteolytic cleavage product that assists in the processing of NS4AB consisting of 2K and NS4B." [PMID:21810535, PRO:ES]


modification



PR:000036831

2K

DenV-2K


"A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen." [PMID:17276984, PRO:ES]


organism-modification



PR:000044765

2K (Dengue virus 2 Thailand/NGS-C/1944)

2K (DEN2N)


"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]

Yes

modification



PR:000036843

NS4B-NS5

DenV-NS4B5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 at the NS4A-NS4B site consisting of NS4B and NS5, which is believed to be mediated by a host cell signal peptidase." [PMID:1531368, PRO:ES]


modification



PR:000036873

NS2B-NS3 polyprotein precursor

DenV-NS2B3


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component protease NS2B-NS3 at the NS2A-NS2B and NS3-NS4 sites and consists of NS2B and NS3." [PMID:10744671, PRO:ES]


modification



PR:000036998

NS1-NS2A

DenV-NS12A


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 consisting of NS1 and NS2A. It includes two N-glycosylated residues at Asn-130 and Asn-207. Example: UniProtKB:P29990, 776-1345, Asn-905/Asn-982, MOD:00160." [PMID:15592895, PRO:DAN, PRO:ES]


modification



PR:000036824

NS1

DenV-NS1


"A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:ES]


Yes
modification



PR:000037000

NS1, with complex sugar attached

DenV-NS1/sugar(+)


"An NS1 that has had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES]


Yes
modification



PR:000037001

NS1, without complex sugar attached

DenV-NS1/sugar(-)


"An NS1 that has not had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES]


Yes
organism-modification



PR:000044758

NS1 (Dengue virus 2 Thailand/NGS-C/1944)

NS1 (DEN2N)


"An NS1 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:DNx]

Yes

modification



PR:000036825

NS2A

DenV-NS2A


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome and a component of the viral replication complex." [PMID:23408612, PRO:ES]


organism-modification



PR:000044759

NS2A (Dengue virus 2 Thailand/NGS-C/1944)

NS2A (DEN2N)


"An NS2A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1128-1345." [PRO:DNx]

Yes

organism-modification



PR:000044760

NS2A (Dengue virus 2 Thailand/16681/84)

NS2A (DEN26)


"An NS2A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 1128-1345." [PRO:DNx]

Yes

modification



PR:000036839

NS345

DenV-NS345


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component proteinase NS2B-NS3 at the NS2B-NS3 site consisting of NS3, NS4A, NS4B, and NS5." [PMID:1433530, PRO:ES]


modification



PR:000036828

NS3

DenV-NS3


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural, multifunctional protein encoded by the dengue virus RNA genome with a serine protease domain." [PMID:10744671, PRO:ES]


Yes
organism-modification



PR:000044762

NS3 (Dengue virus 2 Thailand/NGS-C/1944)

NS3 (DEN2N)


"An NS3 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1476-2093." [PRO:DNx]

Yes

modification



PR:000036840

NS4A-NS4B-NS5

DenV-NS4AB5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS345 by the two-component proteinase NS2B-NS3 at the NS3-NS4A site consisting of NS4A, 2K, NS4B, and NS5." [PMID:1531368, PRO:ES]


modification



PR:000036841

NS4AB

DenV-NS4AB


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 by the two-component proteinase NS2B-NS3 at the NS4B-NS5 sites consisting of NS4A, 2K, and NS4B." [PMID:1531368, PRO:ES]


modification



PR:000036830

NS4A

DenV-NS4A


"A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic non-structural protein encoded by the dengue virus RNA genome that associates with membranes via 4 internal hydrophobic regions which are all able to mediate membrane targeting of a cytosolic reporter protein." [PMID:17276984, PRO:ES]


organism-modification



PR:000044763

NS4A (Dengue virus 2 Thailand/NGS-C/1944)

NS4A (DEN2N)


"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]

Yes

organism-modification



PR:000044764

NS4A (Dengue virus 2 Thailand/16681/84)

NS4A (DEN26)


"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]

Yes

modification



PR:000036842

2KNS4B

DenV-2KNS4B


"A dengue virus genome polyprotein proteolytic cleavage product that assists in the processing of NS4AB consisting of 2K and NS4B." [PMID:21810535, PRO:ES]


modification



PR:000036831

2K

DenV-2K


"A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen." [PMID:17276984, PRO:ES]


organism-modification



PR:000044765

2K (Dengue virus 2 Thailand/NGS-C/1944)

2K (DEN2N)


"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]

Yes

modification



PR:000036843

NS4B-NS5

DenV-NS4B5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 at the NS4A-NS4B site consisting of NS4B and NS5, which is believed to be mediated by a host cell signal peptidase." [PMID:1531368, PRO:ES]


modification



PR:000036840

NS4A-NS4B-NS5

DenV-NS4AB5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS345 by the two-component proteinase NS2B-NS3 at the NS3-NS4A site consisting of NS4A, 2K, NS4B, and NS5." [PMID:1531368, PRO:ES]


modification



PR:000036841

NS4AB

DenV-NS4AB


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 by the two-component proteinase NS2B-NS3 at the NS4B-NS5 sites consisting of NS4A, 2K, and NS4B." [PMID:1531368, PRO:ES]


modification



PR:000036830

NS4A

DenV-NS4A


"A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic non-structural protein encoded by the dengue virus RNA genome that associates with membranes via 4 internal hydrophobic regions which are all able to mediate membrane targeting of a cytosolic reporter protein." [PMID:17276984, PRO:ES]


organism-modification



PR:000044763

NS4A (Dengue virus 2 Thailand/NGS-C/1944)

NS4A (DEN2N)


"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]

Yes

organism-modification



PR:000044764

NS4A (Dengue virus 2 Thailand/16681/84)

NS4A (DEN26)


"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]

Yes

modification



PR:000036842

2KNS4B

DenV-2KNS4B


"A dengue virus genome polyprotein proteolytic cleavage product that assists in the processing of NS4AB consisting of 2K and NS4B." [PMID:21810535, PRO:ES]


modification



PR:000036831

2K

DenV-2K


"A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen." [PMID:17276984, PRO:ES]


organism-modification



PR:000044765

2K (Dengue virus 2 Thailand/NGS-C/1944)

2K (DEN2N)


"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]

Yes

modification



PR:000036843

NS4B-NS5

DenV-NS4B5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 at the NS4A-NS4B site consisting of NS4B and NS5, which is believed to be mediated by a host cell signal peptidase." [PMID:1531368, PRO:ES]


modification



PR:000036841

NS4AB

DenV-NS4AB


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 by the two-component proteinase NS2B-NS3 at the NS4B-NS5 sites consisting of NS4A, 2K, and NS4B." [PMID:1531368, PRO:ES]


modification



PR:000036830

NS4A

DenV-NS4A


"A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic non-structural protein encoded by the dengue virus RNA genome that associates with membranes via 4 internal hydrophobic regions which are all able to mediate membrane targeting of a cytosolic reporter protein." [PMID:17276984, PRO:ES]


organism-modification



PR:000044763

NS4A (Dengue virus 2 Thailand/NGS-C/1944)

NS4A (DEN2N)


"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]

Yes

organism-modification



PR:000044764

NS4A (Dengue virus 2 Thailand/16681/84)

NS4A (DEN26)


"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]

Yes

modification



PR:000036842

2KNS4B

DenV-2KNS4B


"A dengue virus genome polyprotein proteolytic cleavage product that assists in the processing of NS4AB consisting of 2K and NS4B." [PMID:21810535, PRO:ES]


modification



PR:000036831

2K

DenV-2K


"A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen." [PMID:17276984, PRO:ES]


organism-modification



PR:000044765

2K (Dengue virus 2 Thailand/NGS-C/1944)

2K (DEN2N)


"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]

Yes

modification



PR:000036842

2KNS4B

DenV-2KNS4B


"A dengue virus genome polyprotein proteolytic cleavage product that assists in the processing of NS4AB consisting of 2K and NS4B." [PMID:21810535, PRO:ES]


modification



PR:000036831

2K

DenV-2K


"A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen." [PMID:17276984, PRO:ES]


organism-modification



PR:000044765

2K (Dengue virus 2 Thailand/NGS-C/1944)

2K (DEN2N)


"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]

Yes

modification



PR:000036843

NS4B-NS5

DenV-NS4B5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 at the NS4A-NS4B site consisting of NS4B and NS5, which is believed to be mediated by a host cell signal peptidase." [PMID:1531368, PRO:ES]


modification



PR:000036873

NS2B-NS3 polyprotein precursor

DenV-NS2B3


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component protease NS2B-NS3 at the NS2A-NS2B and NS3-NS4 sites and consists of NS2B and NS3." [PMID:10744671, PRO:ES]


modification



PR:000036998

NS1-NS2A

DenV-NS12A


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 consisting of NS1 and NS2A. It includes two N-glycosylated residues at Asn-130 and Asn-207. Example: UniProtKB:P29990, 776-1345, Asn-905/Asn-982, MOD:00160." [PMID:15592895, PRO:DAN, PRO:ES]


modification



PR:000036824

NS1

DenV-NS1


"A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:ES]


Yes
modification



PR:000037000

NS1, with complex sugar attached

DenV-NS1/sugar(+)


"An NS1 that has had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES]


Yes
modification



PR:000037001

NS1, without complex sugar attached

DenV-NS1/sugar(-)


"An NS1 that has not had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES]


Yes
organism-modification



PR:000044758

NS1 (Dengue virus 2 Thailand/NGS-C/1944)

NS1 (DEN2N)


"An NS1 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:DNx]

Yes

modification



PR:000036825

NS2A

DenV-NS2A


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome and a component of the viral replication complex." [PMID:23408612, PRO:ES]


organism-modification



PR:000044759

NS2A (Dengue virus 2 Thailand/NGS-C/1944)

NS2A (DEN2N)


"An NS2A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1128-1345." [PRO:DNx]

Yes

organism-modification



PR:000044760

NS2A (Dengue virus 2 Thailand/16681/84)

NS2A (DEN26)


"An NS2A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 1128-1345." [PRO:DNx]

Yes

modification



PR:000036822

E protein

DenV-E


"A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein containing two alpha-helices (EH1 and EH2) at the C-terminus and two transmembrane domains (ET1 and ET2) of the dengue virus RNA genome. It contains two N-linked glycosylation sites, at Asn-67 and Asn-153. Example: UniProtKB:P29990, 281-775, Asn-347/Asn-433, MOD:00160." [PMID:17459925, PMID:23300717, PRO:DAN, PRO:ES]


Yes
modification



PR:000036836

C-prM

DenV-CprM


"A dengue virus genome polyprotein proteolytic cleavage product that is derived from dengue virus genome polyprotein, glycosylated form and that consists only of the C (capsid) protein and the prM (pre-membrane) structural proteins of the dengue virus genome polyprotein. It has a single N-linked glycosylation site at position Asn-69. Example: UniProtKB:P29990, 1-280, Asn-183, MOD:00160." [PMID:14963133, PRO:DAN, PRO:ES]


modification



PR:000036819

capsid protein C

DenV-C


"A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein processed at the N-terminal end of the dengue virus RNA genome." [PRO:ES]


modification



PR:000036837

prM

DenV-prM


"A dengue virus genome polyprotein proteolytic cleavage product that is a product of the cleavage of C-prM by host signalase. It has a single N-linked glycosylation site at position Asn-69. Example: UniProtKB:P29990, 115-280, Asn-183, MOD:00160." [PMID:14963133, PRO:DAN, PRO:ES]


Yes
modification



PR:000036820

pr protein

DenV-pr


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor form prM protein on the surface of immature dengue virus by host protease during virion maturation." [PMID:23559476, PRO:ES]


modification



PR:000036821

M protein

DenV-M


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor prM and localizes to the endoplasmic reticulum and forms oligomers." [PMID:22569259, PRO:ES]


organism-modification



PR:000044757

M protein (Dengue virus 2 Thailand/16681/84)

M (DEN26)


"An M protein in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 206-280." [PRO:DNx]

Yes

organism-modification



PR:000044769

prM (Dengue virus 2 Thailand/16681/84)

prM (DEN26)


"A prM in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 115-280, Asn-183, MOD:00160." [PRO:DNx]

Yes

organism-modification



PR:000044770

prM (Dengue virus 2 Thailand/NGS-C/1944)

prM (DEN2N)


"A prM in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 115-280, Asn-183, MOD:00160." [PRO:DNx]

Yes

modification



PR:000036838

NS12345

DenV-NS12345


"A dengue virus genome polyprotein proteolytic cleavage product that is derived from dengue virus genome polyprotein, N-glycosylated form and that contains the entire non-structural region of the dengue virus genome polyprotein only and is responsible for directing viral genomic RNA replication, including synthesizing negative- and positive-strand RNAs and forming the viral RNA cap structure. It consists of NS1, NS2A, NS3, NS4A, 2K, NS4B, and NS5." [PMID:1433530, PMID:22022449, PRO:ES]


modification



PR:000036826

NS2A-alpha

DenV-NS2Aalpha


"A dengue virus genome polyprotein proteolytic cleavage product that consists of 188 amino acids at the N-terminal end of NS2A." [PMID:23408612, PRO:ES]


modification



PR:000036827

NS2B

DenV-NS2B


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome containing a conserved hydrophilic domain necessary for protease activity in cleavage of the dengue virus genome polyprotein, N-glycosylated form." [PMID:10744671, PRO:ES]


Yes
organism-modification



PR:000044761

NS2B (Dengue virus 2 Thailand/NGS-C/1944)

NS2B (DEN2N)


"An NS2B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1346-1475." [PRO:DNx]

Yes

modification



PR:000036839

NS345

DenV-NS345


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component proteinase NS2B-NS3 at the NS2B-NS3 site consisting of NS3, NS4A, NS4B, and NS5." [PMID:1433530, PRO:ES]


modification



PR:000036828

NS3

DenV-NS3


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural, multifunctional protein encoded by the dengue virus RNA genome with a serine protease domain." [PMID:10744671, PRO:ES]


Yes
organism-modification



PR:000044762

NS3 (Dengue virus 2 Thailand/NGS-C/1944)

NS3 (DEN2N)


"An NS3 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1476-2093." [PRO:DNx]

Yes

modification



PR:000036840

NS4A-NS4B-NS5

DenV-NS4AB5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS345 by the two-component proteinase NS2B-NS3 at the NS3-NS4A site consisting of NS4A, 2K, NS4B, and NS5." [PMID:1531368, PRO:ES]


modification



PR:000036841

NS4AB

DenV-NS4AB


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 by the two-component proteinase NS2B-NS3 at the NS4B-NS5 sites consisting of NS4A, 2K, and NS4B." [PMID:1531368, PRO:ES]


modification



PR:000036830

NS4A

DenV-NS4A


"A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic non-structural protein encoded by the dengue virus RNA genome that associates with membranes via 4 internal hydrophobic regions which are all able to mediate membrane targeting of a cytosolic reporter protein." [PMID:17276984, PRO:ES]


organism-modification



PR:000044763

NS4A (Dengue virus 2 Thailand/NGS-C/1944)

NS4A (DEN2N)


"An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx]

Yes

organism-modification



PR:000044764

NS4A (Dengue virus 2 Thailand/16681/84)

NS4A (DEN26)


"An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx]

Yes

modification



PR:000036842

2KNS4B

DenV-2KNS4B


"A dengue virus genome polyprotein proteolytic cleavage product that assists in the processing of NS4AB consisting of 2K and NS4B." [PMID:21810535, PRO:ES]


modification



PR:000036831

2K

DenV-2K


"A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen." [PMID:17276984, PRO:ES]


organism-modification



PR:000044765

2K (Dengue virus 2 Thailand/NGS-C/1944)

2K (DEN2N)


"A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx]

Yes

modification



PR:000036843

NS4B-NS5

DenV-NS4B5


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 at the NS4A-NS4B site consisting of NS4B and NS5, which is believed to be mediated by a host cell signal peptidase." [PMID:1531368, PRO:ES]


modification



PR:000036873

NS2B-NS3 polyprotein precursor

DenV-NS2B3


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component protease NS2B-NS3 at the NS2A-NS2B and NS3-NS4 sites and consists of NS2B and NS3." [PMID:10744671, PRO:ES]


modification



PR:000036998

NS1-NS2A

DenV-NS12A


"A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 consisting of NS1 and NS2A. It includes two N-glycosylated residues at Asn-130 and Asn-207. Example: UniProtKB:P29990, 776-1345, Asn-905/Asn-982, MOD:00160." [PMID:15592895, PRO:DAN, PRO:ES]


modification



PR:000036824

NS1

DenV-NS1


"A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:ES]


Yes
modification



PR:000037000

NS1, with complex sugar attached

DenV-NS1/sugar(+)


"An NS1 that has had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES]


Yes
modification



PR:000037001

NS1, without complex sugar attached

DenV-NS1/sugar(-)


"An NS1 that has not had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES]


Yes
organism-modification



PR:000044758

NS1 (Dengue virus 2 Thailand/NGS-C/1944)

NS1 (DEN2N)


"An NS1 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:DNx]

Yes

modification



PR:000036825

NS2A

DenV-NS2A


"A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome and a component of the viral replication complex." [PMID:23408612, PRO:ES]


organism-modification



PR:000044759

NS2A (Dengue virus 2 Thailand/NGS-C/1944)

NS2A (DEN2N)


"An NS2A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1128-1345." [PRO:DNx]

Yes

organism-modification



PR:000044760

NS2A (Dengue virus 2 Thailand/16681/84)

NS2A (DEN26)


"An NS2A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 1128-1345." [PRO:DNx]

Yes

Back to top
DenV-polyprot forms found in complexes   

DenV-polyprot Component
Complexes
PR:000036822 DenV-E PR:000036823 prM-E complex
PR:000036999 E protein dimer
PR:000036824 DenV-NS1 PR:000037002 NS1 dimer
PR:000036827 DenV-NS2B PR:000036829 NS2B-NS3 complex
PR:000036828 DenV-NS3 PR:000036829 NS2B-NS3 complex
PR:000036837 DenV-prM PR:000036823 prM-E complex
PR:000037000 DenV-NS1/sugar(+) PR:000037003 NS1 dimer, with complex sugar attached
PR:000037005 NS1 hexamer, with complex sugar attached
PR:000037001 DenV-NS1/sugar(-) PR:000037004 NS1 dimer, without complex sugar unattached
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044757 M (DEN26)
UniProtKB:P29990, 206-280
acts_upstream_of_or_withinGO:0006955 immune response PMID:14963133
located_inGO:0019031 viral envelope PMID:14963133
PR:000044758 NS1 (DEN2N)
UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160
acts_upstream_of_or_withinGO:0019079 viral genome replication PMID:23408612
GO:0097281 immune complex formation PMID:23408612
located_inGO:0019034 viral replication complex PMID:23408612
PR:000044759 NS2A (DEN2N)
UniProtKB:P14340, 1128-1345
acts_upstream_of_or_withinGO:0019068 virion assembly PMID:23408612
GO:0019076 viral release from host cell PMID:23408612
GO:0019079 viral genome replication PMID:23408612
located_inGO:0019034 viral replication complex PMID:23408612
PR:000044760 NS2A (DEN26)
UniProtKB:P29990, 1128-1345
acts_upstream_of_or_withinGO:0060339 negative regulation of type I interferon-mediated signaling pathway PMID:14612562
PR:000044761 NS2B (DEN2N)
UniProtKB:P14340, 1346-1475
acts_upstream_of_or_withinGO:1900005 positive regulation of serine-type endopeptidase activity PMID:10744671
enablescontributes_to GO:0008236 serine-type peptidase activity PMID:10744671
PR:000044762 NS3 (DEN2N)
UniProtKB:P14340, 1476-2093
acts_upstream_of_or_withinGO:0019082 viral protein processing PMID:10744671
enablesGO:0003724 RNA helicase activity PMID:10744671
GO:0008236 serine-type peptidase activity PMID:10744671
GO:0017111 ribonucleoside triphosphate phosphatase activity PMID:10744671
PR:000044763 NS4A (DEN2N)
UniProtKB:P14340, 2094-2220
acts_upstream_of_or_withinGO:0019079 viral genome replication PMID:17276984
located_inGO:0019034 viral replication complex PMID:17276984
PR:000044764 NS4A (DEN26)
UniProtKB:P29990, 2094-2220
acts_upstream_of_or_withinGO:0060339 negative regulation of type I interferon-mediated signaling pathway PMID:14612562
PR:000044765 2K (DEN2N)
UniProtKB:P14340, 2221-2243
acts_upstream_of_or_withinGO:0045051 protein insertion into ER membrane by internal uncleaved signal-anchor sequence PMID:17276984
enablesGO:0043495 protein-membrane adaptor activity PMID:21810535
located_inGO:0016020 membrane PMID:21810535
PR:000044766 NS4B (DEN2N)
UniProtKB:P14340, 2244-2491
acts_upstream_of_or_withinGO:0019079 viral genome replication PMID:21810535
located_inGO:0019034 viral replication complex PMID:21810535
PR:000044767 NS4B (DEN26)
UniProtKB:P29990, 2244-2491
acts_upstream_of_or_withinGO:0039563 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity PMID:14612562
PR:000044768 NS5 (DEN2N)
UniProtKB:P14340, 2492-3391
acts_upstream_of_or_withinGO:0001510 RNA methylation PMID:21810535
GO:0019079 viral genome replication PMID:21810535
GO:0042783 symbiont-mediated evasion of host immune response PMID:21810535
enablesGO:0003968 RNA-directed RNA polymerase activity PMID:21810535
GO:0008168 methyltransferase activity PMID:21810535
GO:0070568 guanylyltransferase activity PMID:23408612
located_inGO:0019034 viral replication complex PMID:21810535
PR:000044769 prM (DEN26)
UniProtKB:P29990, 115-280, Asn-183, MOD:00160
acts_upstream_of_or_withinGO:0015031 protein transport PMID:14963133
GO:0019068 virion assembly PMID:14963133
enablesGO:0044183 protein folding chaperone PMID:14963133
PR:000044770 prM (DEN2N)
UniProtKB:P14340, 115-280, Asn-183, MOD:00160
acts_upstream_of_or_withinGO:0006955 immune response PMID:8429301
located_inGO:0019031 viral envelope PMID:8429301