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Protein Ontology report - trypsin, signal peptide removed form
PR:000036291 - http://purl.obolibrary.org/obo/PR_000036291
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036291   
  PRO nametrypsin, signal peptide removed form 
  Synonyms
PRO-Short-label: EXACT:PRSS/SigPep-
Other: EXACT:trypsinogen
  Definition"A trypsin that has had the signal peptide removed." [PRO:DAN] 
  PRO Categorymodification 
  ParentPR:000027795 trypsin
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification32                                                  Organism-Modification 32                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
modification



PR:000036291

trypsin, signal peptide removed form

PRSS/SigPep-


"A trypsin that has had the signal peptide removed." [PRO:DAN]


modification



PR:000018779

prostate-specific antigen, signal peptide removed form

KLK3/SigPep-


"A prostate-specific antigen that has had the signal peptide removed." [PRO:DNx]


modification



PR:000025453

prostate-specific antigen isoform 1, signal peptide removed form

KLK3/iso:1/SigPep-


"A prostate-specific antigen isoform 1 that has had the signal peptide removed." [PRO:DAN]


modification



PR:000003018

prostate-specific antigen isoform 1 cleaved and glycosylated form

KLK3/iso:1/ClvGlyco+


"A prostate-specific antigen isoform 1, signal peptide removed form that has had the propeptide removed and that includes at least one glycosylated residue." [PRO:CNA]


modification



PR:000003019

prostate-specific antigen isoform 1 cleaved and N-glycosylated 1

KLK3/iso:1/ClvNGlyco:1


"A prostate-specific antigen isoform 1 cleaved and glycosylated form that contains an N-glycosylated Asn residue within the glycosylation consensus sequence near its N terminus. Example: UniProtKB:P07288-1, 25-261, Asn-69, MOD:00160." [PMID:2422647, PMID:3691515, PRO:CNA, PRO:DAN]


organism-modification



PR:000070532

prostate-specific antigen, mature form (human)

hKLK3/mature


"A prostate-specific antigen (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P07288-1, 25-261." [PRO:DNx, Reactome:R-HSA-381416]


modification



PR:000018822

granzyme D, signal peptide removed form

Gzmd/SigPep-


"A granzyme D that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026635

granzyme D isoform 1, signal peptide removed form

Gzmd/iso:1/SigPep-


"A granzyme D isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018825

granzyme G, signal peptide removed form

Gzmg/SigPep-


"A granzyme G that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026722

granzyme G isoform 1, signal peptide removed form

Gzmg/iso:1/SigPep-


"A granzyme G isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018828

granzyme E, signal peptide removed form

Gzme/SigPep-


"A granzyme E that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026595

granzyme E isoform 1, signal peptide removed form

Gzme/iso:1/SigPep-


"A granzyme E isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018831

granzyme C, signal peptide removed form

Gzmc/SigPep-


"A granzyme C that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026721

granzyme C isoform 1, signal peptide removed form

Gzmc/iso:1/SigPep-


"A granzyme C isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018834

granzyme H, signal peptide removed form

GZMH/SigPep-


"A granzyme H that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026717

granzyme H isoform 1, signal peptide removed form

GZMH/iso:1/SigPep-


"A granzyme H isoform 1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000074268

granzyme H, mature form (human)

hGZMH/mature


"A granzyme H (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P20718-1, 21-246." [PRO:DNx, Reactome:R-HSA-2990875]


modification



PR:000018837

granzyme F, signal peptide removed form

Gzmf/SigPep-


"A granzyme F that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026685

granzyme F isoform 1, signal peptide removed form

Gzmf/iso:1/SigPep-


"A granzyme F isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000019097

azurocidin, signal peptide removed form

AZU1/SigPep-


"An azurocidin that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000073944

azurocidin, mature form (human)

hAZU1/mature


"An azurocidin (human) that has had the signal peptide and all propeptides removed. UniProtKB:P20160, 27-248." [PRO:DNx, Reactome:R-HSA-6798767, Reactome:R-HSA-6806193]


modification



PR:000019381

chymase, signal peptide removed form

CMA1/SigPep-


"A chymase that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000074937

chymase, mature form (human)

hCMA1/mature


"A chymase (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P23946-1, 22-247." [PRO:DNx, Reactome:R-HSA-708327]


modification



PR:000019548

chymotrypsinogen B, signal peptide removed form

CTRB1/SigPep-


"A chymotrypsinogen B that has had the signal peptide removed." [PRO:DNx]


modification



PR:000019775

chymotrypsin-like elastase family member 2A, signal peptide removed form

ELA2A/SigPep-


"A chymotrypsin-like elastase family member 2A that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000037244

chymotrypsin-like elastase family member 2A, pro-form (mouse)

mCELA2A/pro


"A chymotrypsin-like elastase family member 2A, signal peptide removed form in mouse. UniProtKB:P05208, 17-271." [PMID:20179351, PRO:KRC]


organism-modification



PR:000037245

chymotrypsin-like elastase family member 2A, mature form (mouse)

mCELA2A/mature


"A chymotrypsin-like elastase family member 2A, pro-form (mouse) that has had the activation peptide removed by proteolytic cleavage. UniProtKB:P05208, 31-271." [PMID:20179351, PMID:3641189, PRO:KRC]

Yes

organism-modification



PR:000071040

chymotrypsin-like elastase family member 2A, mature form (human)

hCELA2A/mature


"A chymotrypsin-like elastase family member 2A (human) that has had the signal peptide and propeptide removed. UniProtKB:P08217, 29-269." [PRO:DNx, Reactome:R-HSA-8849616, Reactome:R-HSA-8934818]


modification



PR:000019778

chymotrypsin-like elastase family member 2B, signal peptide removed form

ELA2B/SigPep-


"A chymotrypsin-like elastase family member 2B that has had the signal peptide removed." [PRO:DNx]


modification



PR:000020385

kallikrein-14, signal peptide removed form

KLK14/SigPep-


"A kallikrein-14 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000085370

kallikrein-14, mature form (human)

hKLK14/mature


"A kallikrein-14 (human) that has had the signal peptide and propeptide removed. UniProtKB:Q9P0G3, 41-267." [PRO:DNx, Reactome:R-HSA-5694595]


modification



PR:000020388

kallikrein-7, signal peptide removed form

KLK7/SigPep-


"A kallikrein-7 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000076167

kallikrein-7, mature form (human)

hKLK7/mature


"A kallikrein-7 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P49862-1, 30-253." [PRO:DNx, Reactome:R-HSA-3827967, Reactome:R-HSA-9727975]


modification



PR:000021125

serine protease 1, signal peptide removed form

PRSS1/SigPep-


"A serine protease 1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000048939

serine protease 1, signal peptide removed form (human)

hPRSS1/SigPep-


"A serine protease 1 (human) that has had the signal peptide removed. UniProtKB:P07477, 16-247." [PRO:DNx]


modification



PR:000021131

myeloblastin, signal peptide removed form

PRTN3/SigPep-


"A myeloblastin that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000074979

myeloblastin, mature form (human)

hPRTN3/mature


"A myeloblastin (human) that has had the signal peptide and all propeptides removed. UniProtKB:P24158, 28-248." [PRO:DNx, Reactome:R-HSA-448623, Reactome:R-HSA-5610100, Reactome:R-HSA-6799223, Reactome:R-HSA-6801682]


modification



PR:000021729

tryptase beta-2, signal peptide removed form

TPSB2/SigPep-


"A tryptase beta-2 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000050080

tryptase beta-2, mature form (human)

hTPSB2/mature


"A tryptase beta-2 (human) that has had the signal peptide and propeptide removed. UniProtKB:P20231, 31-275." [PRO:DNx, UniProtKB:P20231]


modification



PR:000026632

granzyme A, signal peptide removed form

GZMA/SigPep-


"A granzyme A that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026633

granzyme A isoform 1, signal peptide removed form

GZMA/iso:1/SigPep-


"A granzyme A isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026712

granzyme B, signal peptide removed form

GZMB/SigPep-


"A granzyme B that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026713

granzyme B isoform 1, signal peptide removed form

GZMB/iso:1/SigPep-


"A granzyme B isoform 1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000071760

granzyme B, mature form (human)

hGZMB/mature


"A granzyme B (human) that has had the signal peptide and propeptide removed. UniProtKB:P10144, 21-247." [PRO:DNx, Reactome:R-HSA-55915, Reactome:R-HSA-6807037]


modification



PR:000028941

activated trypsin

PRSS/ProPep-


"A trypsin, signal peptide removed form that has been activated by removal of the propeptide (activation peptide)." [PRO:DAN]


modification



PR:000003018

prostate-specific antigen isoform 1 cleaved and glycosylated form

KLK3/iso:1/ClvGlyco+


"A prostate-specific antigen isoform 1, signal peptide removed form that has had the propeptide removed and that includes at least one glycosylated residue." [PRO:CNA]


modification



PR:000003019

prostate-specific antigen isoform 1 cleaved and N-glycosylated 1

KLK3/iso:1/ClvNGlyco:1


"A prostate-specific antigen isoform 1 cleaved and glycosylated form that contains an N-glycosylated Asn residue within the glycosylation consensus sequence near its N terminus. Example: UniProtKB:P07288-1, 25-261, Asn-69, MOD:00160." [PMID:2422647, PMID:3691515, PRO:CNA, PRO:DAN]


organism-modification



PR:000037245

chymotrypsin-like elastase family member 2A, mature form (mouse)

mCELA2A/mature


"A chymotrypsin-like elastase family member 2A, pro-form (mouse) that has had the activation peptide removed by proteolytic cleavage. UniProtKB:P05208, 31-271." [PMID:20179351, PMID:3641189, PRO:KRC]

Yes

organism-modification



PR:000050073

tryptase alpha/beta-1, mature form (human)

hTPSAB1/mature


"A tryptase alpha/beta-1 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:Q15661-1, 31-275." [PRO:DNx, UniProtKB:Q15661]


organism-modification



PR:000050080

tryptase beta-2, mature form (human)

hTPSB2/mature


"A tryptase beta-2 (human) that has had the signal peptide and propeptide removed. UniProtKB:P20231, 31-275." [PRO:DNx, UniProtKB:P20231]


organism-modification



PR:000059609

chymotrypsin-C isoform 1 active form (mouse)

mCTRC/iso:1/active


"A chymotrypsin-C isoform 1 (mouse) that has had the signal peptide and the propeptide removed. Propeptide (aka activation peptide) cleavage is mediated by trypsin, and yields the mature active form. UniProtKB:Q3SYP2-1, 30-268." [PRO:KRC]


organism-modification



PR:000066317

kallikrein-8, mature form (human)

hKLK8/mature


"A kallikrein-8 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:O60259-1, 33-260." [PRO:DNx, Reactome:R-HSA-8850833]


organism-modification



PR:000067395

complement factor D, mature form (human)

hCFD/mature


"A complement factor D (human) that has had the signal peptide and propeptide removed. UniProtKB:P00746, 26-253." [PRO:DNx, Reactome:R-HSA-139852, Reactome:R-HSA-51919, Reactome:R-HSA-6804790, Reactome:R-HSA-6804805]


organism-modification



PR:000070514

kallikrein-1, mature form (human)

hKLK1/mature


"A kallikrein-1 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P06870-1, 25-262." [PRO:DNx, Reactome:R-HSA-2990870]


organism-modification



PR:000070532

prostate-specific antigen, mature form (human)

hKLK3/mature


"A prostate-specific antigen (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P07288-1, 25-261." [PRO:DNx, Reactome:R-HSA-381416]


organism-modification



PR:000070737

trypsin-2, mature form (human)

hPRSS2/mature


"A trypsin-2 (human) that has had the signal peptide and propeptide removed. UniProtKB:P07478, 24-247." [PRO:DNx, Reactome:R-HSA-1460243, Reactome:R-HSA-6799229]


organism-modification



PR:000071040

chymotrypsin-like elastase family member 2A, mature form (human)

hCELA2A/mature


"A chymotrypsin-like elastase family member 2A (human) that has had the signal peptide and propeptide removed. UniProtKB:P08217, 29-269." [PRO:DNx, Reactome:R-HSA-8849616, Reactome:R-HSA-8934818]


organism-modification



PR:000071078

neutrophil elastase, mature form (human)

hELANE/mature


"A neutrophil elastase (human) that has had the signal peptide and propeptide removed. UniProtKB:P08246, 30-267." [PRO:DNx, Reactome:R-HSA-1602474, Reactome:R-HSA-6799238, Reactome:R-HSA-6800918, Reactome:R-HSA-9710109]


organism-modification



PR:000071760

granzyme B, mature form (human)

hGZMB/mature


"A granzyme B (human) that has had the signal peptide and propeptide removed. UniProtKB:P10144, 21-247." [PRO:DNx, Reactome:R-HSA-55915, Reactome:R-HSA-6807037]


organism-modification



PR:000073907

kallikrein-2, mature form (human)

hKLK2/mature


"A kallikrein-2 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P20151-1, 25-261." [PRO:DNx, Reactome:R-HSA-1604753]


organism-modification



PR:000073944

azurocidin, mature form (human)

hAZU1/mature


"An azurocidin (human) that has had the signal peptide and all propeptides removed. UniProtKB:P20160, 27-248." [PRO:DNx, Reactome:R-HSA-6798767, Reactome:R-HSA-6806193]


organism-modification



PR:000074268

granzyme H, mature form (human)

hGZMH/mature


"A granzyme H (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P20718-1, 21-246." [PRO:DNx, Reactome:R-HSA-2990875]


organism-modification



PR:000074937

chymase, mature form (human)

hCMA1/mature


"A chymase (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P23946-1, 22-247." [PRO:DNx, Reactome:R-HSA-708327]


organism-modification



PR:000074979

myeloblastin, mature form (human)

hPRTN3/mature


"A myeloblastin (human) that has had the signal peptide and all propeptides removed. UniProtKB:P24158, 28-248." [PRO:DNx, Reactome:R-HSA-448623, Reactome:R-HSA-5610100, Reactome:R-HSA-6799223, Reactome:R-HSA-6801682]


organism-modification



PR:000075628

trypsin-3, mature form (human)

hPRSS3/mature


"A trypsin-3 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P35030-1, 81-304." [PRO:DNx, Reactome:R-HSA-1460244, Reactome:R-HSA-6800432]


organism-modification



PR:000076167

kallikrein-7, mature form (human)

hKLK7/mature


"A kallikrein-7 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P49862-1, 30-253." [PRO:DNx, Reactome:R-HSA-3827967, Reactome:R-HSA-9727975]


organism-modification



PR:000076290

granzyme M, mature form (human)

hGZMM/mature


"A granzyme M (human) that has had the signal peptide and propeptide removed. UniProtKB:P51124, 26-257." [PRO:DNx, Reactome:R-HSA-2975823]


organism-modification



PR:000081268

serine protease 41, mature GPI-anchored 1 (human)

hPRSS41/mature/anchored:1


"A serine protease 41 (human) that has had the signal peptide and all propeptides removed, and that has been GPI-anchored on the residue at the position equivalent to Ser-299 of the amino acid sequence represented by UniProtKB:Q7RTY9. UniProtKB:Q7RTY9, 55-299, Ser-299, MOD:00171." [PRO:DNx, Reactome:R-HSA-8940698]


organism-modification



PR:000085370

kallikrein-14, mature form (human)

hKLK14/mature


"A kallikrein-14 (human) that has had the signal peptide and propeptide removed. UniProtKB:Q9P0G3, 41-267." [PRO:DNx, Reactome:R-HSA-5694595]


organism-modification



PR:000086024

testisin, mature GPI-anchored 1 (human)

hPRSS21/mature/anchored:1


"A testisin (human) that has had the signal peptide and all propeptides removed, and that has been GPI-anchored on the residue at the position equivalent to Ser-288 of the amino acid sequence represented by UniProtKB:Q9Y6M0-1. Example: UniProtKB:Q9Y6M0-1, 42-288, Ser-288, MOD:00171." [PRO:DNx, Reactome:R-HSA-8940704]


organism-modification



PR:000059630

chymotrypsin-C isoform 1 inactive form (mouse)

mCTRC/iso:1/inactive


"A chymotrypsin-C isoform 1 (mouse) that has had the signal peptide removed but retains the propeptide. Propeptide (aka activation peptide) removal is required for activation, hence this form is inactive. UniProtKB:Q3SYP2-1, 17-268." [PRO:DAN, PRO:KRC]


organism-modification



PR:000061262

kallikrein-8, signal peptide removed form (human)

hKLK8/SigPep-


"A kallikrein-8 (human) that has had the signal peptide removed. Example: UniProtKB:O60259-1, 29-260." [PRO:DNx, Reactome:R-HSA-8850832]


organism-modification



PR:000066317

kallikrein-8, mature form (human)

hKLK8/mature


"A kallikrein-8 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:O60259-1, 33-260." [PRO:DNx, Reactome:R-HSA-8850833]


organism-modification



PR:000062154

kallikrein-5, signal peptide removed form (human)

hKLK5/SigPep-


"A kallikrein-5 (human) that has had the signal peptide removed. UniProtKB:Q9Y337, 23-293." [PRO:DNx, Reactome:R-HSA-8849836]


organism-modification



PR:000085817

chymotrypsin-C, signal peptide removed form (human)

hCTRC/SigPep-


"A chymotrypsin-C (human) that has had the signal peptide removed. UniProtKB:Q99895, 17-268." [PRO:DNx, Reactome:R-HSA-9922787]


organism-modification



PR:000085857

kallikrein-1, signal peptide removed form (human)

hKLK1/SigPep-


"A kallikrein-1 (human) that has had the signal peptide removed. Example: UniProtKB:P06870-1, 19-262." [PRO:DNx, Reactome:R-HSA-9923895]


organism-modification



PR:000070514

kallikrein-1, mature form (human)

hKLK1/mature


"A kallikrein-1 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:P06870-1, 25-262." [PRO:DNx, Reactome:R-HSA-2990870]


organism-modification



PR:000085878

chymotrypsin-like protease CTRL-1, signal peptide removed form (human)

hCTRL/SigPep-


"A chymotrypsin-like protease CTRL-1 (human) that has had the signal peptide removed. UniProtKB:P40313, 19-264." [PRO:DNx, Reactome:R-HSA-9922800]


organism-modification



PR:000085888

chymotrypsin-like elastase family member 3B, signal peptide removed form (human)

hCELA3B/SigPep-


"A chymotrypsin-like elastase family member 3B (human) that has had the signal peptide removed. UniProtKB:P08861, 16-270." [PRO:DNx, Reactome:R-HSA-9922712]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037245 mCELA2A/mature
UniProtKB:P05208, 31-271
acts_upstream_of_or_withinGO:0006508 proteolysis MGI_ref:4440399; PMID:20179351
GO:0061436 establishment of skin barrier MGI_ref:4440399; PMID:20179351
enablesGO:0017171 serine hydrolase activity MGI_ref:4440399; PMID:20179351
GO:0017171 serine hydrolase activity MGI_ref:4440399; PMID:20179351