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Protein Ontology report - activated TLR4 complex
PR:000036076 - http://purl.obolibrary.org/obo/PR_000036076
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036076   
  PRO nameactivated TLR4 complex 
  Synonyms
PRO-Short-label: EXACT:TLR4actv
Other: EXACT:LY96:LPS:TLR4 complex | MD2:LPS:TLR4 complex | TLR4MD2LPS complex
  Definition"A protein-containing complex that contains TLR4, LPS and MD2(LY96)." [PMID:19252480, PRO:DAN, Reactome:R-HSA-166041, TLR:AMM] 
  CommentRequested by=TLR. Based on the crystal structure, known points of disulfide bonding, and other information, it is likely that the protein components correspond to PR:000003299 and PR:000025492. [PRO:DAN]. 
  PRO Categorycomplex 
  ParentG0043235 receptor complex
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Complex1                                                  Organism-Complex 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?
complex



PR:000036076 activated TLR4 complex

TLR4actv


organism-complex



PR:000036077 activated TLR4 complex (mouse)

mTLR4actv

Yes

organism-complex



PR:000037474 activated TLR4 complex (chicken)

chick-TLR4actv

Yes

organism-complex



PR:000044684 activated TLR4 complex (human)

hTLR4actv


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathwayPR:000036077 mTLR4actv PMID:23565187
GO:0034142 toll-like receptor 4 signaling pathwayPR:000037474 chick-TLR4actv PMID:18768894
GO:0045429 positive regulation of nitric oxide biosynthetic processPR:000037474 chick-TLR4actv PMID:24034933
GO:0051607 defense response to virusPR:000037474 chick-TLR4actv PMID:24034933

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005886 plasma membranePR:000037474 chick-TLR4actv Reactome:REACT_25442