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Protein Ontology report - spindle assembly checkpoint component MAD3
PR:000035499 - http://purl.obolibrary.org/obo/PR_000035499
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000035499   
  PRO namespindle assembly checkpoint component MAD3 
  Synonyms
PRO-Short-label: EXACT:MAD3
Other: Mitotic MAD3 protein (BROAD)
  Definition"A protein that is a translation product of the yeast MAD3 gene or a 1:1 ortholog thereof. MAD3 is related to BUB1 and BUB1B, all of which contain the Mad3/BUB1 homology region 1 (Pfam:PF00831), but MAD3 lacks the C-terminal Protein kinase domain (Pfam:PF00069)." [PMID:15970700, PMID:22698286, PRO:KER] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000035499
spindle assembly checkpoint component MAD3
MAD3
"A protein that is a translation product of the yeast MAD3 gene or a 1:1 ortholog thereof. MAD3 is related to BUB1 and BUB1B, all of which contain the Mad3/BUB1 homology region 1 (Pfam:PF00831), but MAD3 lacks the C-terminal Protein kinase domain (Pfam:PF00069)." [PMID:15970700, PMID:22698286, PRO:KER]

organism-gene


PR:O59767
mitotic spindle checkpoint component mad3 (Schizosaccharomyces pombe 972h-)
Spom972h-MAD3
"A spindle assembly checkpoint component MAD3 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PMID:11909965, PRO:KER]
Yes
Yes
organism-gene


PR:P47074
spindle assembly checkpoint component MAD3 (yeast)
yMAD3
"A spindle assembly checkpoint component MAD3 that is encoded in the genome of yeast." [PMID:15970700, PRO:KER]
Yes
organism-modification


PR:000035501
spindle assembly checkpoint component MAD3 phosphorylated 1 (yeast)
yMAD3/Phos:1
"A spindle assembly checkpoint component MAD3 phosphorylated 1 in yeast. UniProtKB:P47074, Ser-268, MOD:00046|(Ser-466, MOD:00046 and/or Ser-504, MOD:00046)." [PMID:15970700, PRO:DAN, PRO:KER]

organism-modification


PR:000035503
spindle assembly checkpoint component MAD3 phosphorylated 2 (yeast)
yMAD3/Phos:2
"A spindle assembly checkpoint component MAD3 phosphorylated 2 in yeast. Phosphorylation is necessary for normal response to a lack of kinetochore tension but not for response to lack of microtubule binding to kinetochores. In addition to the phosphorylation annotated, this form might also be phosphorylated on Ser-10 and Ser-486. UniProtKB:P47074, Ser-303/Ser-337, MOD:00046." [PMID:17504936, PRO:KER]
Yes
organism-modification


PR:000035506
spindle assembly checkpoint component MAD3 unphosphorylated form (yeast)
yMAD3/PhosRes-
"A spindle assembly checkpoint component MAD3 unphosphorylated form in yeast." [PRO:KER]

modification


PR:000035500
spindle assembly checkpoint component MAD3 phosphorylated 1
MAD3/Phos:1
"A spindle assembly checkpoint component MAD3 that has been phosphorylated during spindle checkpoint activation. Example: UniProtKB:P47074, Ser-268, MOD:00046|(Ser-466, MOD:00046 and/or Ser-504, MOD:00046)." [PMID:15970700, PRO:DAN, PRO:KER]

organism-modification


PR:000035501
spindle assembly checkpoint component MAD3 phosphorylated 1 (yeast)
yMAD3/Phos:1
"A spindle assembly checkpoint component MAD3 phosphorylated 1 in yeast. UniProtKB:P47074, Ser-268, MOD:00046|(Ser-466, MOD:00046 and/or Ser-504, MOD:00046)." [PMID:15970700, PRO:DAN, PRO:KER]

modification


PR:000035502
spindle assembly checkpoint component MAD3 phosphorylated 2
MAD3/Phos:2
"A spindle assembly checkpoint component MAD3 that has been phosphorylated during spindle checkpoint activation on residues equivalent to Ser-303 and Ser-337 of the amino acid sequence represented by UniProtKB:P47074. Example: UniProtKB:P47074, Ser-303/Ser-337, MOD:00046." [PMID:17504936, PRO:KER]

organism-modification


PR:000035503
spindle assembly checkpoint component MAD3 phosphorylated 2 (yeast)
yMAD3/Phos:2
"A spindle assembly checkpoint component MAD3 phosphorylated 2 in yeast. Phosphorylation is necessary for normal response to a lack of kinetochore tension but not for response to lack of microtubule binding to kinetochores. In addition to the phosphorylation annotated, this form might also be phosphorylated on Ser-10 and Ser-486. UniProtKB:P47074, Ser-303/Ser-337, MOD:00046." [PMID:17504936, PRO:KER]
Yes
modification


PR:000035505
spindle assembly checkpoint component MAD3 unphosphorylated form
MAD3/PhosRes-
"A spindle assembly checkpoint component MAD3 that lacks phosphorylated residues." [PRO:KER]

organism-modification


PR:000035506
spindle assembly checkpoint component MAD3 unphosphorylated form (yeast)
yMAD3/PhosRes-
"A spindle assembly checkpoint component MAD3 unphosphorylated form in yeast." [PRO:KER]

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MAD3 forms found in complexes   

MAD3 Component
 Complexes
PR:O59767 Spom972h-MAD3 PR:000035574 MAD2:MAD3 complex (Schizosaccharomyces pombe 972h-)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035503 yMAD3/Phos:2
UniProtKB:P47074, Ser-303/Ser-337, MOD:00046		 acts_upstream_of_or_withinincreased GO:0031577 spindle checkpoint signaling relative to PR:000035506 yMAD3 unphosphorylated PMID:17504936
PR:O59767 Spom972h-MAD3 enablesGO:0005515 protein binding with PR:O14417 mad2 PMID:12676091
located_inGO:0000776 kinetochore PMID:12676091
PR:P47074 yMAD3 acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:15514023
GO:0031577 spindle checkpoint signaling PMID:15970700
enablesGO:0005515 protein binding with PR:P26309 CDC20 IntAct:EBI-1269217
GO:0005515 protein binding with PR:P26449 BUB3 IntAct:EBI-1269217
GO:0005515 protein binding with PR:P40958 J1256 IntAct:EBI-1269217