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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3
PR:000035431 - http://purl.obolibrary.org/obo/PR_000035431
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000035431   
  PRO namemitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 
  Synonyms
PRO-Short-label: EXACT:BUB1B/Phos:3
Other: RELATED:BUBR1 phosphorylated
  Definition"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated on the residue at the position equivalent to Thr-608 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER] 
  CommentThere is some controversy in the literature on whether BUB1B has kinase activity or is a pseudokinase. 
  PRO Categorymodification 
  ParentPR:000004855 mitotic checkpoint serine/threonine-protein kinase BUB1 beta
PR:000037070 phosphoprotein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000035431
mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3
BUB1B/Phos:3
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated on the residue at the position equivalent to Thr-608 of the amino acid sequence represented by UniProtKB:O60566-1. Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]

organism-modification


PR:000035432
mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human)
hBUB1B/Phos:3
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in human. This phosphorylated form is observed in prometaphase and in conditions of spindle depolymerization (nocodazole). Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]
Yes
organism-modification


PR:000035433
mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (frog)
frog-BUB1B/Phos:3
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in frog. UniProtKB:Q8JGT8, Thr-593, MOD:00047." [PMID:22801780, PRO:KER]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035432 hBUB1B/Phos:3
Example: UniProtKB:O60566-1, Thr-608, MOD:00047		 acts_upstream_of_or_withindecreased GO:0001933 negative regulation of protein phosphorylation relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0007059 chromosome segregation relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0031577 spindle checkpoint signaling relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0034501 protein localization to kinetochore relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
increased GO:0051310 metaphase chromosome alignment relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780
located_inGO:0000776 kinetochore PMID:22801780